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Large cell neuroendocrine carcinoma of the lung metastatic to the cauda equina.
Spine J. 2010 Jun; 10(6):e1-5.SJ

Abstract

BACKGROUND CONTEXT

Large cell neuroendocrine carcinoma of the lung is an aggressive tumor with unique histopathological features. It is not known to metastasize to the spine.

PURPOSE

To report a metastatic case of this rare tumor to the cauda equina.

STUDY DESIGN

Case report.

METHODS

Retrospective case review and review of the literature.

RESULTS

The authors report a rare case of a large cell neuroendocrine lung metastasis to the lumbar spine, causing right foot drop. Magnetic resonance imaging revealed a heterogeneously enhancing intradural extramedullary mass at L2/L3 level compressing the surrounding nerve roots. During surgery, the identified nerve roots were encased by the tumor, and the dissection was tedious. Postoperatively, the patient reported significantly improved back pain and he had severe foot weakness. The functional outcome was poor because the patient lost entirely his foot function; however, his back pain improved significantly after surgery.

CONCLUSIONS

This is the first published study in which the authors described a metastasis of a rather uncommon lung cancer to the cauda equina. When a lesion of the cauda equina presents with a rapid progressive neurological deficit, leptomeningeal metastasis should be in the differential diagnosis.

Authors+Show Affiliations

Department of Neurological Surgery, University of Miami, Miller School of Medicine, Lois Pope Life Center, Miami, FL 33136, USA. atsimpas@med.miami.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

20494806

Citation

Tsimpas, Asterios, et al. "Large Cell Neuroendocrine Carcinoma of the Lung Metastatic to the Cauda Equina." The Spine Journal : Official Journal of the North American Spine Society, vol. 10, no. 6, 2010, pp. e1-5.
Tsimpas A, Post NH, Moshel Y, et al. Large cell neuroendocrine carcinoma of the lung metastatic to the cauda equina. Spine J. 2010;10(6):e1-5.
Tsimpas, A., Post, N. H., Moshel, Y., & Frempong-Boadu, A. K. (2010). Large cell neuroendocrine carcinoma of the lung metastatic to the cauda equina. The Spine Journal : Official Journal of the North American Spine Society, 10(6), e1-5. https://doi.org/10.1016/j.spinee.2010.03.031
Tsimpas A, et al. Large Cell Neuroendocrine Carcinoma of the Lung Metastatic to the Cauda Equina. Spine J. 2010;10(6):e1-5. PubMed PMID: 20494806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Large cell neuroendocrine carcinoma of the lung metastatic to the cauda equina. AU - Tsimpas,Asterios, AU - Post,Nicholas H, AU - Moshel,Yaron, AU - Frempong-Boadu,Anthony K, PY - 2009/10/20/received PY - 2010/02/05/revised PY - 2010/03/29/accepted PY - 2010/5/25/entrez PY - 2010/5/25/pubmed PY - 2010/8/21/medline SP - e1 EP - 5 JF - The spine journal : official journal of the North American Spine Society JO - Spine J VL - 10 IS - 6 N2 - BACKGROUND CONTEXT: Large cell neuroendocrine carcinoma of the lung is an aggressive tumor with unique histopathological features. It is not known to metastasize to the spine. PURPOSE: To report a metastatic case of this rare tumor to the cauda equina. STUDY DESIGN: Case report. METHODS: Retrospective case review and review of the literature. RESULTS: The authors report a rare case of a large cell neuroendocrine lung metastasis to the lumbar spine, causing right foot drop. Magnetic resonance imaging revealed a heterogeneously enhancing intradural extramedullary mass at L2/L3 level compressing the surrounding nerve roots. During surgery, the identified nerve roots were encased by the tumor, and the dissection was tedious. Postoperatively, the patient reported significantly improved back pain and he had severe foot weakness. The functional outcome was poor because the patient lost entirely his foot function; however, his back pain improved significantly after surgery. CONCLUSIONS: This is the first published study in which the authors described a metastasis of a rather uncommon lung cancer to the cauda equina. When a lesion of the cauda equina presents with a rapid progressive neurological deficit, leptomeningeal metastasis should be in the differential diagnosis. SN - 1878-1632 UR - https://www.unboundmedicine.com/medline/citation/20494806/Large_cell_neuroendocrine_carcinoma_of_the_lung_metastatic_to_the_cauda_equina_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1529-9430(10)00287-1 DB - PRIME DP - Unbound Medicine ER -