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Associations between anthropometry, cigarette smoking, alcohol consumption, and non-Hodgkin lymphoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
Am J Epidemiol 2010; 171(12):1270-81AJ

Abstract

Prospective studies of lifestyle and non-Hodgkin lymphoma (NHL) are conflicting, and some are inconsistent with case-control studies. The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial was used to evaluate risk of NHL and its subtypes in association with anthropometric factors, smoking, and alcohol consumption in a prospective cohort study. Lifestyle was assessed via questionnaire among 142,982 male and female participants aged 55-74 years enrolled in the PLCO Trial during 1993-2001. Hazard ratios and 95% confidence intervals were calculated using Cox proportional hazards regression. During 1,201,074 person-years of follow-up through 2006, 1,264 histologically confirmed NHL cases were identified. Higher body mass index (BMI; weight (kg)/height (m)(2)) at ages 20 and 50 years and at baseline was associated with increased NHL risk (P(trend) < 0.01 for all; e.g., for baseline BMI > or =30 vs. 18.5-24.9, hazard ratio = 1.32, 95% confidence interval: 1.13, 1.54). Smoking was not associated with NHL overall but was inversely associated with follicular lymphoma (ever smoking vs. never: hazard ratio = 0.62, 95% confidence interval: 0.45, 0.85). Alcohol consumption was unrelated to NHL (drinks/week: P(trend) = 0.187). These data support previous studies suggesting that BMI is positively associated with NHL, show an inverse association between smoking and follicular lymphoma (perhaps due to residual confounding), and do not support a causal association between alcohol and NHL.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, School of Public Health and Health Services, George Washington University, Washington, DC, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

20494998

Citation

Troy, Jesse D., et al. "Associations Between Anthropometry, Cigarette Smoking, Alcohol Consumption, and non-Hodgkin Lymphoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial." American Journal of Epidemiology, vol. 171, no. 12, 2010, pp. 1270-81.
Troy JD, Hartge P, Weissfeld JL, et al. Associations between anthropometry, cigarette smoking, alcohol consumption, and non-Hodgkin lymphoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Am J Epidemiol. 2010;171(12):1270-81.
Troy, J. D., Hartge, P., Weissfeld, J. L., Oken, M. M., Colditz, G. A., Mechanic, L. E., & Morton, L. M. (2010). Associations between anthropometry, cigarette smoking, alcohol consumption, and non-Hodgkin lymphoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. American Journal of Epidemiology, 171(12), pp. 1270-81. doi:10.1093/aje/kwq085.
Troy JD, et al. Associations Between Anthropometry, Cigarette Smoking, Alcohol Consumption, and non-Hodgkin Lymphoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Am J Epidemiol. 2010 Jun 15;171(12):1270-81. PubMed PMID: 20494998.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations between anthropometry, cigarette smoking, alcohol consumption, and non-Hodgkin lymphoma in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. AU - Troy,Jesse D, AU - Hartge,Patricia, AU - Weissfeld,Joel L, AU - Oken,Martin M, AU - Colditz,Graham A, AU - Mechanic,Leah E, AU - Morton,Lindsay M, Y1 - 2010/05/21/ PY - 2010/5/25/entrez PY - 2010/5/25/pubmed PY - 2010/6/23/medline SP - 1270 EP - 81 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 171 IS - 12 N2 - Prospective studies of lifestyle and non-Hodgkin lymphoma (NHL) are conflicting, and some are inconsistent with case-control studies. The Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial was used to evaluate risk of NHL and its subtypes in association with anthropometric factors, smoking, and alcohol consumption in a prospective cohort study. Lifestyle was assessed via questionnaire among 142,982 male and female participants aged 55-74 years enrolled in the PLCO Trial during 1993-2001. Hazard ratios and 95% confidence intervals were calculated using Cox proportional hazards regression. During 1,201,074 person-years of follow-up through 2006, 1,264 histologically confirmed NHL cases were identified. Higher body mass index (BMI; weight (kg)/height (m)(2)) at ages 20 and 50 years and at baseline was associated with increased NHL risk (P(trend) < 0.01 for all; e.g., for baseline BMI > or =30 vs. 18.5-24.9, hazard ratio = 1.32, 95% confidence interval: 1.13, 1.54). Smoking was not associated with NHL overall but was inversely associated with follicular lymphoma (ever smoking vs. never: hazard ratio = 0.62, 95% confidence interval: 0.45, 0.85). Alcohol consumption was unrelated to NHL (drinks/week: P(trend) = 0.187). These data support previous studies suggesting that BMI is positively associated with NHL, show an inverse association between smoking and follicular lymphoma (perhaps due to residual confounding), and do not support a causal association between alcohol and NHL. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/20494998/Associations_between_anthropometry_cigarette_smoking_alcohol_consumption_and_non_Hodgkin_lymphoma_in_the_Prostate_Lung_Colorectal_and_Ovarian_Cancer_Screening_Trial_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwq085 DB - PRIME DP - Unbound Medicine ER -