Tags

Type your tag names separated by a space and hit enter

Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: modeling odds ratios in pooled case-control data.
Am J Epidemiol. 2010 Jun 15; 171(12):1250-61.AJ

Abstract

Odds ratios for head and neck cancer increase with greater cigarette and alcohol use and lower body mass index (BMI; weight (kg)/height(2) (m(2))). Using data from the International Head and Neck Cancer Epidemiology Consortium, the authors conducted a formal analysis of BMI as a modifier of smoking- and alcohol-related effects. Analysis of never and current smokers included 6,333 cases, while analysis of never drinkers and consumers of < or =10 drinks/day included 8,452 cases. There were 8,000 or more controls, depending on the analysis. Odds ratios for all sites increased with lower BMI, greater smoking, and greater drinking. In polytomous regression, odds ratios for BMI (P = 0.65), smoking (P = 0.52), and drinking (P = 0.73) were homogeneous for oral cavity and pharyngeal cancers. Odds ratios for BMI and drinking were greater for oral cavity/pharyngeal cancer (P < 0.01), while smoking odds ratios were greater for laryngeal cancer (P < 0.01). Lower BMI enhanced smoking- and drinking-related odds ratios for oral cavity/pharyngeal cancer (P < 0.01), while BMI did not modify smoking and drinking odds ratios for laryngeal cancer. The increased odds ratios for all sites with low BMI may suggest related carcinogenic mechanisms; however, BMI modification of smoking and drinking odds ratios for cancer of the oral cavity/pharynx but not larynx cancer suggests additional factors specific to oral cavity/pharynx cancer.

Authors+Show Affiliations

Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Rockville, MD 20852, USA. lubinj@mail.nih.govNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

20494999

Citation

Lubin, Jay H., et al. "Body Mass Index, Cigarette Smoking, and Alcohol Consumption and Cancers of the Oral Cavity, Pharynx, and Larynx: Modeling Odds Ratios in Pooled Case-control Data." American Journal of Epidemiology, vol. 171, no. 12, 2010, pp. 1250-61.
Lubin JH, Gaudet MM, Olshan AF, et al. Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: modeling odds ratios in pooled case-control data. Am J Epidemiol. 2010;171(12):1250-61.
Lubin, J. H., Gaudet, M. M., Olshan, A. F., Kelsey, K., Boffetta, P., Brennan, P., Castellsague, X., Chen, C., Curado, M. P., Dal Maso, L., Daudt, A. W., Fabianova, E., Fernandez, L., Wünsch-Filho, V., Franceschi, S., Herrero, R., Koifman, S., La Vecchia, C., Lazarus, P., ... Hayes, R. B. (2010). Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: modeling odds ratios in pooled case-control data. American Journal of Epidemiology, 171(12), 1250-61. https://doi.org/10.1093/aje/kwq088
Lubin JH, et al. Body Mass Index, Cigarette Smoking, and Alcohol Consumption and Cancers of the Oral Cavity, Pharynx, and Larynx: Modeling Odds Ratios in Pooled Case-control Data. Am J Epidemiol. 2010 Jun 15;171(12):1250-61. PubMed PMID: 20494999.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: modeling odds ratios in pooled case-control data. AU - Lubin,Jay H, AU - Gaudet,Mia M, AU - Olshan,Andrew F, AU - Kelsey,Karl, AU - Boffetta,Paolo, AU - Brennan,Paul, AU - Castellsague,Xavier, AU - Chen,Chu, AU - Curado,Maria Paula, AU - Dal Maso,Luigino, AU - Daudt,Alexander W, AU - Fabianova,Eleonora, AU - Fernandez,Leticia, AU - Wünsch-Filho,Victor, AU - Franceschi,Silvia, AU - Herrero,Rolando, AU - Koifman,Sergio, AU - La Vecchia,Carlo, AU - Lazarus,Philip, AU - Levi,Fabio, AU - Lissowska,Jolanta, AU - Mates,Ioan Nicolae, AU - Matos,Elena, AU - McClean,Michael, AU - Menezes,Ana, AU - Morgenstern,Hal, AU - Muscat,Joshua, AU - Eluf Neto,Jose, AU - Purdue,Mark P, AU - Rudnai,Peter, AU - Schwartz,Stephen M, AU - Shangina,Oxana, AU - Sturgis,Erich M, AU - Szeszenia-Dabrowska,Neonilia, AU - Talamini,Renato, AU - Wei,Qingyi, AU - Winn,Deborah, AU - Zhang,Zuo-Feng, AU - Hashibe,Mia, AU - Hayes,Richard B, Y1 - 2010/05/21/ PY - 2010/5/25/entrez PY - 2010/5/25/pubmed PY - 2010/6/23/medline SP - 1250 EP - 61 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 171 IS - 12 N2 - Odds ratios for head and neck cancer increase with greater cigarette and alcohol use and lower body mass index (BMI; weight (kg)/height(2) (m(2))). Using data from the International Head and Neck Cancer Epidemiology Consortium, the authors conducted a formal analysis of BMI as a modifier of smoking- and alcohol-related effects. Analysis of never and current smokers included 6,333 cases, while analysis of never drinkers and consumers of < or =10 drinks/day included 8,452 cases. There were 8,000 or more controls, depending on the analysis. Odds ratios for all sites increased with lower BMI, greater smoking, and greater drinking. In polytomous regression, odds ratios for BMI (P = 0.65), smoking (P = 0.52), and drinking (P = 0.73) were homogeneous for oral cavity and pharyngeal cancers. Odds ratios for BMI and drinking were greater for oral cavity/pharyngeal cancer (P < 0.01), while smoking odds ratios were greater for laryngeal cancer (P < 0.01). Lower BMI enhanced smoking- and drinking-related odds ratios for oral cavity/pharyngeal cancer (P < 0.01), while BMI did not modify smoking and drinking odds ratios for laryngeal cancer. The increased odds ratios for all sites with low BMI may suggest related carcinogenic mechanisms; however, BMI modification of smoking and drinking odds ratios for cancer of the oral cavity/pharynx but not larynx cancer suggests additional factors specific to oral cavity/pharynx cancer. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/20494999/Body_mass_index_cigarette_smoking_and_alcohol_consumption_and_cancers_of_the_oral_cavity_pharynx_and_larynx:_modeling_odds_ratios_in_pooled_case_control_data_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwq088 DB - PRIME DP - Unbound Medicine ER -