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Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: modeling odds ratios in pooled case-control data.
Am J Epidemiol. 2010 Jun 15; 171(12):1250-61.AJ

Abstract

Odds ratios for head and neck cancer increase with greater cigarette and alcohol use and lower body mass index (BMI; weight (kg)/height(2) (m(2))). Using data from the International Head and Neck Cancer Epidemiology Consortium, the authors conducted a formal analysis of BMI as a modifier of smoking- and alcohol-related effects. Analysis of never and current smokers included 6,333 cases, while analysis of never drinkers and consumers of < or =10 drinks/day included 8,452 cases. There were 8,000 or more controls, depending on the analysis. Odds ratios for all sites increased with lower BMI, greater smoking, and greater drinking. In polytomous regression, odds ratios for BMI (P = 0.65), smoking (P = 0.52), and drinking (P = 0.73) were homogeneous for oral cavity and pharyngeal cancers. Odds ratios for BMI and drinking were greater for oral cavity/pharyngeal cancer (P < 0.01), while smoking odds ratios were greater for laryngeal cancer (P < 0.01). Lower BMI enhanced smoking- and drinking-related odds ratios for oral cavity/pharyngeal cancer (P < 0.01), while BMI did not modify smoking and drinking odds ratios for laryngeal cancer. The increased odds ratios for all sites with low BMI may suggest related carcinogenic mechanisms; however, BMI modification of smoking and drinking odds ratios for cancer of the oral cavity/pharynx but not larynx cancer suggests additional factors specific to oral cavity/pharynx cancer.

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Authors+Show Affiliations

Lubin JH
Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, 6120 Executive Blvd., Rockville, MD 20852, USA. lubinj@mail.nih.gov
Gaudet MM
No affiliation info available
Olshan AF
No affiliation info available
Kelsey K
No affiliation info available
Boffetta P
No affiliation info available
Brennan P
No affiliation info available
Castellsague X
No affiliation info available
Chen C
No affiliation info available
Curado MP
No affiliation info available
Dal Maso L
No affiliation info available
Daudt AW
No affiliation info available
Fabianova E
No affiliation info available
Fernandez L
No affiliation info available
Wünsch-Filho V
No affiliation info available
Franceschi S
No affiliation info available
Herrero R
No affiliation info available
Koifman S
No affiliation info available
La Vecchia C
No affiliation info available
Lazarus P
No affiliation info available
Levi F
No affiliation info available
Lissowska J
No affiliation info available
Mates IN
No affiliation info available
Matos E
No affiliation info available
McClean M
No affiliation info available
Menezes A
No affiliation info available
Morgenstern H
No affiliation info available
Muscat J
No affiliation info available
Eluf Neto J
No affiliation info available
Purdue MP
No affiliation info available
Rudnai P
No affiliation info available
Schwartz SM
No affiliation info available
Shangina O
No affiliation info available
Sturgis EM
No affiliation info available
Szeszenia-Dabrowska N
No affiliation info available
Talamini R
No affiliation info available
Wei Q
No affiliation info available
Winn D
No affiliation info available
Zhang ZF
No affiliation info available
Hashibe M
No affiliation info available
Hayes RB
No affiliation info available

MeSH

Alcohol DrinkingBody Mass IndexCase-Control StudiesHumansLaryngeal NeoplasmsMouth NeoplasmsOdds RatioPharyngeal NeoplasmsRisk FactorsSmoking

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

20494999

Citation

Lubin, Jay H., et al. "Body Mass Index, Cigarette Smoking, and Alcohol Consumption and Cancers of the Oral Cavity, Pharynx, and Larynx: Modeling Odds Ratios in Pooled Case-control Data." American Journal of Epidemiology, vol. 171, no. 12, 2010, pp. 1250-61.
Lubin JH, Gaudet MM, Olshan AF, et al. Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: modeling odds ratios in pooled case-control data. Am J Epidemiol. 2010;171(12):1250-61.
Lubin, J. H., Gaudet, M. M., Olshan, A. F., Kelsey, K., Boffetta, P., Brennan, P., Castellsague, X., Chen, C., Curado, M. P., Dal Maso, L., Daudt, A. W., Fabianova, E., Fernandez, L., Wünsch-Filho, V., Franceschi, S., Herrero, R., Koifman, S., La Vecchia, C., Lazarus, P., ... Hayes, R. B. (2010). Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: modeling odds ratios in pooled case-control data. American Journal of Epidemiology, 171(12), 1250-61. https://doi.org/10.1093/aje/kwq088
Lubin JH, et al. Body Mass Index, Cigarette Smoking, and Alcohol Consumption and Cancers of the Oral Cavity, Pharynx, and Larynx: Modeling Odds Ratios in Pooled Case-control Data. Am J Epidemiol. 2010 Jun 15;171(12):1250-61. PubMed PMID: 20494999.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body mass index, cigarette smoking, and alcohol consumption and cancers of the oral cavity, pharynx, and larynx: modeling odds ratios in pooled case-control data. AU - Lubin,Jay H, AU - Gaudet,Mia M, AU - Olshan,Andrew F, AU - Kelsey,Karl, AU - Boffetta,Paolo, AU - Brennan,Paul, AU - Castellsague,Xavier, AU - Chen,Chu, AU - Curado,Maria Paula, AU - Dal Maso,Luigino, AU - Daudt,Alexander W, AU - Fabianova,Eleonora, AU - Fernandez,Leticia, AU - Wünsch-Filho,Victor, AU - Franceschi,Silvia, AU - Herrero,Rolando, AU - Koifman,Sergio, AU - La Vecchia,Carlo, AU - Lazarus,Philip, AU - Levi,Fabio, AU - Lissowska,Jolanta, AU - Mates,Ioan Nicolae, AU - Matos,Elena, AU - McClean,Michael, AU - Menezes,Ana, AU - Morgenstern,Hal, AU - Muscat,Joshua, AU - Eluf Neto,Jose, AU - Purdue,Mark P, AU - Rudnai,Peter, AU - Schwartz,Stephen M, AU - Shangina,Oxana, AU - Sturgis,Erich M, AU - Szeszenia-Dabrowska,Neonilia, AU - Talamini,Renato, AU - Wei,Qingyi, AU - Winn,Deborah, AU - Zhang,Zuo-Feng, AU - Hashibe,Mia, AU - Hayes,Richard B, Y1 - 2010/05/21/ PY - 2010/5/25/entrez PY - 2010/5/25/pubmed PY - 2010/6/23/medline SP - 1250 EP - 61 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 171 IS - 12 N2 - Odds ratios for head and neck cancer increase with greater cigarette and alcohol use and lower body mass index (BMI; weight (kg)/height(2) (m(2))). Using data from the International Head and Neck Cancer Epidemiology Consortium, the authors conducted a formal analysis of BMI as a modifier of smoking- and alcohol-related effects. Analysis of never and current smokers included 6,333 cases, while analysis of never drinkers and consumers of < or =10 drinks/day included 8,452 cases. There were 8,000 or more controls, depending on the analysis. Odds ratios for all sites increased with lower BMI, greater smoking, and greater drinking. In polytomous regression, odds ratios for BMI (P = 0.65), smoking (P = 0.52), and drinking (P = 0.73) were homogeneous for oral cavity and pharyngeal cancers. Odds ratios for BMI and drinking were greater for oral cavity/pharyngeal cancer (P < 0.01), while smoking odds ratios were greater for laryngeal cancer (P < 0.01). Lower BMI enhanced smoking- and drinking-related odds ratios for oral cavity/pharyngeal cancer (P < 0.01), while BMI did not modify smoking and drinking odds ratios for laryngeal cancer. The increased odds ratios for all sites with low BMI may suggest related carcinogenic mechanisms; however, BMI modification of smoking and drinking odds ratios for cancer of the oral cavity/pharynx but not larynx cancer suggests additional factors specific to oral cavity/pharynx cancer. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/20494999/Body_mass_index_cigarette_smoking_and_alcohol_consumption_and_cancers_of_the_oral_cavity_pharynx_and_larynx:_modeling_odds_ratios_in_pooled_case_control_data_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwq088 DB - PRIME DP - Unbound Medicine ER -