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Finite element analysis of eustachian tube function in cleft palate infants based on histological reconstructions.
Cleft Palate Craniofac J. 2010 Nov; 47(6):600-10.CP

Abstract

INTRODUCTION

The prevalence of otitis media with effusion approaches 100% in infants with cleft palate (CP), and disease pathogenesis is believed to be caused by eustachian tube (ET) dysfunction.

OBJECTIVES

Quantify the functional consequences of ET anatomy in infant CP specimens, and identify the relative importance of various tissue biomechanical properties on ET function in infants with CP.

METHODS

Finite element models of ET anatomy and physiology were developed by using image analysis and three-dimensional (3D) reconstruction techniques. Models were developed using histological images of ET structures obtained from five infant CP specimens. The models were parameterized, and the effects of varying model parameters, which included tensor veli palatini and levator veli palatini force, ET cartilage, periluminal mucosal compliance, and hamular position on resistance to airflow through the tubal lumen, were determined.

RESULTS

Of the evaluated parameters, only applied tensor veli palatini muscle force and compliance of the periluminal mucosa and cartilage tissues were significant predictors of resistance to airflow through the ET during muscle-assisted opening.

CONCLUSIONS

Finite element models of ET function in the CP infant identified tensor veli palatini muscle force as a direct predictor and mucosal/cartilage compliance as an indirect predictor of ET opening during muscle-assisted lumen dilations. Hamular position and levator veli palatini force were not found to have an effect on ET function in CP infants.

Authors+Show Affiliations

Department of Mechanical Engineering, Ohio State University, Columbus, Ohio, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20500073

Citation

Sheer, F J., et al. "Finite Element Analysis of Eustachian Tube Function in Cleft Palate Infants Based On Histological Reconstructions." The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association, vol. 47, no. 6, 2010, pp. 600-10.
Sheer FJ, Swarts JD, Ghadiali SN. Finite element analysis of eustachian tube function in cleft palate infants based on histological reconstructions. Cleft Palate Craniofac J. 2010;47(6):600-10.
Sheer, F. J., Swarts, J. D., & Ghadiali, S. N. (2010). Finite element analysis of eustachian tube function in cleft palate infants based on histological reconstructions. The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association, 47(6), 600-10. https://doi.org/10.1597/09-131
Sheer FJ, Swarts JD, Ghadiali SN. Finite Element Analysis of Eustachian Tube Function in Cleft Palate Infants Based On Histological Reconstructions. Cleft Palate Craniofac J. 2010;47(6):600-10. PubMed PMID: 20500073.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Finite element analysis of eustachian tube function in cleft palate infants based on histological reconstructions. AU - Sheer,F J, AU - Swarts,J D, AU - Ghadiali,S N, Y1 - 2010/03/10/ PY - 2010/5/27/entrez PY - 2010/5/27/pubmed PY - 2014/3/29/medline SP - 600 EP - 10 JF - The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association JO - Cleft Palate Craniofac J VL - 47 IS - 6 N2 - INTRODUCTION: The prevalence of otitis media with effusion approaches 100% in infants with cleft palate (CP), and disease pathogenesis is believed to be caused by eustachian tube (ET) dysfunction. OBJECTIVES: Quantify the functional consequences of ET anatomy in infant CP specimens, and identify the relative importance of various tissue biomechanical properties on ET function in infants with CP. METHODS: Finite element models of ET anatomy and physiology were developed by using image analysis and three-dimensional (3D) reconstruction techniques. Models were developed using histological images of ET structures obtained from five infant CP specimens. The models were parameterized, and the effects of varying model parameters, which included tensor veli palatini and levator veli palatini force, ET cartilage, periluminal mucosal compliance, and hamular position on resistance to airflow through the tubal lumen, were determined. RESULTS: Of the evaluated parameters, only applied tensor veli palatini muscle force and compliance of the periluminal mucosa and cartilage tissues were significant predictors of resistance to airflow through the ET during muscle-assisted opening. CONCLUSIONS: Finite element models of ET function in the CP infant identified tensor veli palatini muscle force as a direct predictor and mucosal/cartilage compliance as an indirect predictor of ET opening during muscle-assisted lumen dilations. Hamular position and levator veli palatini force were not found to have an effect on ET function in CP infants. SN - 1545-1569 UR - https://www.unboundmedicine.com/medline/citation/20500073/Finite_element_analysis_of_eustachian_tube_function_in_cleft_palate_infants_based_on_histological_reconstructions_ L2 - https://journals.sagepub.com/doi/10.1597/09-131?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -