Tags

Type your tag names separated by a space and hit enter

Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids.
Nutr Rev. 2010 May; 68(5):280-9.NR

Abstract

Omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFA) are precursors of potent lipid mediators, termed eicosanoids, which play an important role in the regulation of inflammation. Eicosanoids derived from n-6 PUFAs (e.g., arachidonic acid) have proinflammatory and immunoactive functions, whereas eicosanoids derived from n-3 PUFAs [e.g., eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] have anti-inflammatory properties, traditionally attributed to their ability to inhibit the formation of n-6 PUFA-derived eicosanoids. While the typical Western diet has a much greater ratio of n-6 PUFAs compared with n-3 PUFAs, research has shown that by increasing the ratio of n-3 to n-6 fatty acids in the diet, and consequently favoring the production of EPA in the body, or by increasing the dietary intake of EPA and DHA through consumption of fatty fish or fish-oil supplements, reductions may be achieved in the incidence of many chronic diseases that involve inflammatory processes; most notably, these include cardiovascular diseases, inflammatory bowel disease (IBD), cancer, and rheumatoid arthritis, but psychiatric and neurodegenerative illnesses are other examples.

Authors+Show Affiliations

Alimentary Pharmabiotic Centre (APC), County Cork, Ireland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20500789

Citation

Wall, Rebecca, et al. "Fatty Acids From Fish: the Anti-inflammatory Potential of Long-chain Omega-3 Fatty Acids." Nutrition Reviews, vol. 68, no. 5, 2010, pp. 280-9.
Wall R, Ross RP, Fitzgerald GF, et al. Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids. Nutr Rev. 2010;68(5):280-9.
Wall, R., Ross, R. P., Fitzgerald, G. F., & Stanton, C. (2010). Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids. Nutrition Reviews, 68(5), 280-9. https://doi.org/10.1111/j.1753-4887.2010.00287.x
Wall R, et al. Fatty Acids From Fish: the Anti-inflammatory Potential of Long-chain Omega-3 Fatty Acids. Nutr Rev. 2010;68(5):280-9. PubMed PMID: 20500789.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids. AU - Wall,Rebecca, AU - Ross,R Paul, AU - Fitzgerald,Gerald F, AU - Stanton,Catherine, PY - 2010/5/27/entrez PY - 2010/5/27/pubmed PY - 2010/8/19/medline SP - 280 EP - 9 JF - Nutrition reviews JO - Nutr. Rev. VL - 68 IS - 5 N2 - Omega-6 (n-6) and omega-3 (n-3) polyunsaturated fatty acids (PUFA) are precursors of potent lipid mediators, termed eicosanoids, which play an important role in the regulation of inflammation. Eicosanoids derived from n-6 PUFAs (e.g., arachidonic acid) have proinflammatory and immunoactive functions, whereas eicosanoids derived from n-3 PUFAs [e.g., eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)] have anti-inflammatory properties, traditionally attributed to their ability to inhibit the formation of n-6 PUFA-derived eicosanoids. While the typical Western diet has a much greater ratio of n-6 PUFAs compared with n-3 PUFAs, research has shown that by increasing the ratio of n-3 to n-6 fatty acids in the diet, and consequently favoring the production of EPA in the body, or by increasing the dietary intake of EPA and DHA through consumption of fatty fish or fish-oil supplements, reductions may be achieved in the incidence of many chronic diseases that involve inflammatory processes; most notably, these include cardiovascular diseases, inflammatory bowel disease (IBD), cancer, and rheumatoid arthritis, but psychiatric and neurodegenerative illnesses are other examples. SN - 1753-4887 UR - https://www.unboundmedicine.com/medline/citation/20500789/Fatty_acids_from_fish:_the_anti_inflammatory_potential_of_long_chain_omega_3_fatty_acids_ L2 - https://academic.oup.com/nutritionreviews/article-lookup/doi/10.1111/j.1753-4887.2010.00287.x DB - PRIME DP - Unbound Medicine ER -