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Modifiable risk factors and survival in women diagnosed with primary breast cancer: results from a prospective cohort study.

Abstract

This study examines the impact of smoking, body mass index, alcohol consumption, hormone replacement therapy, and physical activity on all-cause mortality among 528 Danish women diagnosed with primary breast cancer. Participants were women enrolled in the Copenhagen City Heart Study. Prospective self-reported exposure information was collected from four points of follow-up in 1976-1978, 1981-1983, 1991-1994, and 2001-2003. Kaplan-Meier survival curves and multivariate Cox regression analyses were performed adjusting for age, disease stage, adjuvant treatment, menopausal status, parity, alcohol intake, smoking, physical activity, body mass index, and hormone replacement therapy. The study shows that smoking for total mortality [hazard ratio, 1.16; 95% confidence interval, 1.05-1.29] and obesity for both total mortality (1.61; 1.12-2.33) and breast cancer-specific mortality (1.82; 1.11-2.99) were significantly associated with decreased survival after breast cancer diagnosis. A moderate alcohol intake of 1-6 units/week (0.85; 0.64-1.12), 7-14 units/week (0.77; 0.56-1.08), and treatment with hormone replacement therapy (0.79; 0.59-1.05) were less than 1, but not statistically significantly associated with prolonged survival. A moderate physical activity of 2-4 h/week (1.07; 0.77-1.49) and a high physical activity of more than 4 h/week (1.00; 0.69-1.45) showed no association with survival after breast cancer diagnosis.

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  • Authors+Show Affiliations

    ,

    Centre for Alcohol Research, National Institute of Public Health, Copenhagen, Denmark.

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    Source

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Alcohol Drinking
    Body Mass Index
    Breast Neoplasms
    Cause of Death
    Denmark
    Exercise
    Female
    Follow-Up Studies
    Hormone Replacement Therapy
    Humans
    Kaplan-Meier Estimate
    Middle Aged
    Obesity
    Prognosis
    Prospective Studies
    Risk Factors
    Smoking

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    20502344

    Citation

    Hellmann, Sophie Sell, et al. "Modifiable Risk Factors and Survival in Women Diagnosed With Primary Breast Cancer: Results From a Prospective Cohort Study." European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), vol. 19, no. 5, 2010, pp. 366-73.
    Hellmann SS, Thygesen LC, Tolstrup JS, et al. Modifiable risk factors and survival in women diagnosed with primary breast cancer: results from a prospective cohort study. Eur J Cancer Prev. 2010;19(5):366-73.
    Hellmann, S. S., Thygesen, L. C., Tolstrup, J. S., & Grønbaek, M. (2010). Modifiable risk factors and survival in women diagnosed with primary breast cancer: results from a prospective cohort study. European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP), 19(5), pp. 366-73. doi:10.1097/CEJ.0b013e32833b4828.
    Hellmann SS, et al. Modifiable Risk Factors and Survival in Women Diagnosed With Primary Breast Cancer: Results From a Prospective Cohort Study. Eur J Cancer Prev. 2010;19(5):366-73. PubMed PMID: 20502344.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Modifiable risk factors and survival in women diagnosed with primary breast cancer: results from a prospective cohort study. AU - Hellmann,Sophie Sell, AU - Thygesen,Lau Caspar, AU - Tolstrup,Janne Schurmann, AU - Grønbaek,Morten, PY - 2010/5/27/entrez PY - 2010/5/27/pubmed PY - 2010/11/9/medline SP - 366 EP - 73 JF - European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) JO - Eur. J. Cancer Prev. VL - 19 IS - 5 N2 - This study examines the impact of smoking, body mass index, alcohol consumption, hormone replacement therapy, and physical activity on all-cause mortality among 528 Danish women diagnosed with primary breast cancer. Participants were women enrolled in the Copenhagen City Heart Study. Prospective self-reported exposure information was collected from four points of follow-up in 1976-1978, 1981-1983, 1991-1994, and 2001-2003. Kaplan-Meier survival curves and multivariate Cox regression analyses were performed adjusting for age, disease stage, adjuvant treatment, menopausal status, parity, alcohol intake, smoking, physical activity, body mass index, and hormone replacement therapy. The study shows that smoking for total mortality [hazard ratio, 1.16; 95% confidence interval, 1.05-1.29] and obesity for both total mortality (1.61; 1.12-2.33) and breast cancer-specific mortality (1.82; 1.11-2.99) were significantly associated with decreased survival after breast cancer diagnosis. A moderate alcohol intake of 1-6 units/week (0.85; 0.64-1.12), 7-14 units/week (0.77; 0.56-1.08), and treatment with hormone replacement therapy (0.79; 0.59-1.05) were less than 1, but not statistically significantly associated with prolonged survival. A moderate physical activity of 2-4 h/week (1.07; 0.77-1.49) and a high physical activity of more than 4 h/week (1.00; 0.69-1.45) showed no association with survival after breast cancer diagnosis. SN - 1473-5709 UR - https://www.unboundmedicine.com/medline/citation/20502344/Modifiable_risk_factors_and_survival_in_women_diagnosed_with_primary_breast_cancer:_results_from_a_prospective_cohort_study_ L2 - http://Insights.ovid.com/pubmed?pmid=20502344 DB - PRIME DP - Unbound Medicine ER -