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[Hepatitis E virus infection: a paradigm shift?].
Dtsch Med Wochenschr. 2010 Jun; 135(22):1129-33.DM

Abstract

Hepatitis E is an infectious disease caused by the hepatitis E virus (HEV). Hepatitis E is mainly a self-limiting travel-associated disease without chronic evolution. In recent years an increasing number of authochtonous HEV-infections has been described in industrialized countries. HEV-infections frequently take a mild clinical silent course of disease in immunocompetent individuals and thus HEV infection is largely underdiagnosed. Therefore, the anti-HEV-prevalence is much higher than anticipated with 2 - 20% in Western Europe. HEV genotype 3 infections must be considered as zoonotic infections with several animals including swines serving as reservoirs. Cases of HEV-transmissions by blood transfusion were described not only in Asia but also in France and the UK. HEV-infections may take severe courses in pregnant women and patients with chronic liver diseases, sometimes leading to acute liver failure. In addition several centres described cases of progressive chronic HEV-infection in organ transplant recipients and HIV-positive patients during the last two years. In this review we summarize the current state-of-the-art on the knowledge of HEV-infections in industrialised countries.

Authors+Show Affiliations

Gastroenterologie, Medizinische Hochschule Hannover. pischke.sven@mh-hannover.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

ger

PubMed ID

20503140

Citation

Pischke, S, et al. "[Hepatitis E Virus Infection: a Paradigm Shift?]." Deutsche Medizinische Wochenschrift (1946), vol. 135, no. 22, 2010, pp. 1129-33.
Pischke S, Potthoff A, Hauröder B, et al. [Hepatitis E virus infection: a paradigm shift?]. Dtsch Med Wochenschr. 2010;135(22):1129-33.
Pischke, S., Potthoff, A., Hauröder, B., Schlué, J., Manns, M. P., Cornberg, M., & Wedemeyer, H. (2010). [Hepatitis E virus infection: a paradigm shift?]. Deutsche Medizinische Wochenschrift (1946), 135(22), 1129-33. https://doi.org/10.1055/s-0030-1255136
Pischke S, et al. [Hepatitis E Virus Infection: a Paradigm Shift?]. Dtsch Med Wochenschr. 2010;135(22):1129-33. PubMed PMID: 20503140.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Hepatitis E virus infection: a paradigm shift?]. AU - Pischke,S, AU - Potthoff,A, AU - Hauröder,B, AU - Schlué,J, AU - Manns,M P, AU - Cornberg,M, AU - Wedemeyer,H, Y1 - 2010/05/25/ PY - 2010/5/27/entrez PY - 2010/5/27/pubmed PY - 2010/6/18/medline SP - 1129 EP - 33 JF - Deutsche medizinische Wochenschrift (1946) JO - Dtsch. Med. Wochenschr. VL - 135 IS - 22 N2 - Hepatitis E is an infectious disease caused by the hepatitis E virus (HEV). Hepatitis E is mainly a self-limiting travel-associated disease without chronic evolution. In recent years an increasing number of authochtonous HEV-infections has been described in industrialized countries. HEV-infections frequently take a mild clinical silent course of disease in immunocompetent individuals and thus HEV infection is largely underdiagnosed. Therefore, the anti-HEV-prevalence is much higher than anticipated with 2 - 20% in Western Europe. HEV genotype 3 infections must be considered as zoonotic infections with several animals including swines serving as reservoirs. Cases of HEV-transmissions by blood transfusion were described not only in Asia but also in France and the UK. HEV-infections may take severe courses in pregnant women and patients with chronic liver diseases, sometimes leading to acute liver failure. In addition several centres described cases of progressive chronic HEV-infection in organ transplant recipients and HIV-positive patients during the last two years. In this review we summarize the current state-of-the-art on the knowledge of HEV-infections in industrialised countries. SN - 1439-4413 UR - https://www.unboundmedicine.com/medline/citation/20503140/[Hepatitis_E_virus_infection:_a_paradigm_shift]_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0030-1255136 DB - PRIME DP - Unbound Medicine ER -