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Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen.
Prostate. 2010 Jul 01; 70(10):1127-33.P

Abstract

BACKGROUND

Sustained chronic inflammation in the prostate promotes prostate carcinogenesis. Since an elevated level of prostate-specific antigen (PSA) per se reflects the presence of inflammation in the prostate, intervention to improve the PSA value might potentially have beneficial effects for the prevention of the development of prostate cancer. Isoflavones and curcumin have anti-inflammatory and anti-oxidant properties. We examined the biological effects of soy isoflavones and curcumin on LNCaP cells. After that, we conducted a clinical trial for men who received prostate biopsies, but were not found to have prostate cancer, to evaluate the effects of soy isoflavones and curcumin on serum PSA levels.

METHODS

The expression of androgen receptor and PSA were examined in LNCaP cells before and after treatment of isoflavones and/or curcumin. Eighty-five participants were randomized to take a supplement containing isoflavones and curcumin or placebo daily in a double-blind study. Subjects were subdivided by the cut-off of their baseline PSA value at 10 microg/ml. We evaluated values of PSA before and 6 months after treatment.

RESULTS

The production of PSA were markedly decreased by the combined treatment of isoflavones and curcumin in prostate cancer cell line, LNCaP. The expression of the androgen receptor was also suppressed by the treatment. In clinical trials, PSA levels decreased in the patients group with PSA >or= 10 treated with supplement containing isoflavones and curcumin (P = 0.01).

CONCLUSIONS

Our results indicated that isoflavones and curcumin could modulate serum PSA levels. Curcumin presumably synergizes with isoflavones to suppress PSA production in prostate cells through the anti-androgen effects.

Authors+Show Affiliations

Department of Urology, Teikyo University School of Medicine, Itabashi-ku, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

20503397

Citation

Ide, Hisamitsu, et al. "Combined Inhibitory Effects of Soy Isoflavones and Curcumin On the Production of Prostate-specific Antigen." The Prostate, vol. 70, no. 10, 2010, pp. 1127-33.
Ide H, Tokiwa S, Sakamaki K, et al. Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen. Prostate. 2010;70(10):1127-33.
Ide, H., Tokiwa, S., Sakamaki, K., Nishio, K., Isotani, S., Muto, S., Hama, T., Masuda, H., & Horie, S. (2010). Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen. The Prostate, 70(10), 1127-33. https://doi.org/10.1002/pros.21147
Ide H, et al. Combined Inhibitory Effects of Soy Isoflavones and Curcumin On the Production of Prostate-specific Antigen. Prostate. 2010 Jul 1;70(10):1127-33. PubMed PMID: 20503397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen. AU - Ide,Hisamitsu, AU - Tokiwa,Shino, AU - Sakamaki,Kentaro, AU - Nishio,Koujiro, AU - Isotani,Shuji, AU - Muto,Satoru, AU - Hama,Takanori, AU - Masuda,Hiroko, AU - Horie,Shigeo, PY - 2010/5/27/entrez PY - 2010/5/27/pubmed PY - 2010/6/16/medline SP - 1127 EP - 33 JF - The Prostate JO - Prostate VL - 70 IS - 10 N2 - BACKGROUND: Sustained chronic inflammation in the prostate promotes prostate carcinogenesis. Since an elevated level of prostate-specific antigen (PSA) per se reflects the presence of inflammation in the prostate, intervention to improve the PSA value might potentially have beneficial effects for the prevention of the development of prostate cancer. Isoflavones and curcumin have anti-inflammatory and anti-oxidant properties. We examined the biological effects of soy isoflavones and curcumin on LNCaP cells. After that, we conducted a clinical trial for men who received prostate biopsies, but were not found to have prostate cancer, to evaluate the effects of soy isoflavones and curcumin on serum PSA levels. METHODS: The expression of androgen receptor and PSA were examined in LNCaP cells before and after treatment of isoflavones and/or curcumin. Eighty-five participants were randomized to take a supplement containing isoflavones and curcumin or placebo daily in a double-blind study. Subjects were subdivided by the cut-off of their baseline PSA value at 10 microg/ml. We evaluated values of PSA before and 6 months after treatment. RESULTS: The production of PSA were markedly decreased by the combined treatment of isoflavones and curcumin in prostate cancer cell line, LNCaP. The expression of the androgen receptor was also suppressed by the treatment. In clinical trials, PSA levels decreased in the patients group with PSA >or= 10 treated with supplement containing isoflavones and curcumin (P = 0.01). CONCLUSIONS: Our results indicated that isoflavones and curcumin could modulate serum PSA levels. Curcumin presumably synergizes with isoflavones to suppress PSA production in prostate cells through the anti-androgen effects. SN - 1097-0045 UR - https://www.unboundmedicine.com/medline/citation/20503397/Combined_inhibitory_effects_of_soy_isoflavones_and_curcumin_on_the_production_of_prostate_specific_antigen_ L2 - https://doi.org/10.1002/pros.21147 DB - PRIME DP - Unbound Medicine ER -