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Peritoneal fluid leptin levels are increased but adiponectin levels are not changed in infertile patients with pelvic endometriosis.
Gynecol Endocrinol 2010; 26(11):843-9GE

Abstract

OBJECTIVE

Endometriosis is a leading cause of infertility, and recent studies suggest that leptin and adiponectin may have a role in its causation and progression. This study assessed levels of leptin and adiponectin in serum and peritoneal fluid (PF) in patients with endometriosis and infertility.

DESIGN AND SETTING

This cross-sectional study included women undergoing diagnostic and/or therapeutic laparoscopy for endometriosis with chief complaint of infertility. Following laparoscopy, patients diagnosed with endometriosis served as cases while patients with no endometriosis served as controls. Patients with polycystic ovarian syndrome, diabetes, thyroiditis and patients on prior therapy with danazol or leuprolide were excluded from the study. Leptin and adiponectin levels were analysed in blood and PF using commercially available ELISA kits.

RESULTS

Of the 50 patients (aged 22-41 years), 15 had endometriosis (cases) while 35 had no endometriosis (controls). The median PF leptin level was significantly higher in cases as compared to controls (27.7 vs. 15.6 ng/ml, p = 0.019), and this remained significant even when PF leptin was BMI-normalised (p = 0.004). However, median serum leptin and adiponectin levels remained comparable between the two groups.

CONCLUSIONS

This study confirmed the role of PF leptin in causation and progression of endometriosis. However, this would have been definitive if healthy fertile females were included in this study.

Authors+Show Affiliations

Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20504092

Citation

Pandey, Nitin, et al. "Peritoneal Fluid Leptin Levels Are Increased but Adiponectin Levels Are Not Changed in Infertile Patients With Pelvic Endometriosis." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 26, no. 11, 2010, pp. 843-9.
Pandey N, Kriplani A, Yadav RK, et al. Peritoneal fluid leptin levels are increased but adiponectin levels are not changed in infertile patients with pelvic endometriosis. Gynecol Endocrinol. 2010;26(11):843-9.
Pandey, N., Kriplani, A., Yadav, R. K., Lyngdoh, B. T., & Mahapatra, S. C. (2010). Peritoneal fluid leptin levels are increased but adiponectin levels are not changed in infertile patients with pelvic endometriosis. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 26(11), pp. 843-9. doi:10.3109/09513590.2010.487585.
Pandey N, et al. Peritoneal Fluid Leptin Levels Are Increased but Adiponectin Levels Are Not Changed in Infertile Patients With Pelvic Endometriosis. Gynecol Endocrinol. 2010;26(11):843-9. PubMed PMID: 20504092.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peritoneal fluid leptin levels are increased but adiponectin levels are not changed in infertile patients with pelvic endometriosis. AU - Pandey,Nitin, AU - Kriplani,Alka, AU - Yadav,Raj Kumar, AU - Lyngdoh,Basil T, AU - Mahapatra,Sushil Chandra, PY - 2010/5/28/entrez PY - 2010/5/28/pubmed PY - 2011/2/15/medline SP - 843 EP - 9 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 26 IS - 11 N2 - OBJECTIVE: Endometriosis is a leading cause of infertility, and recent studies suggest that leptin and adiponectin may have a role in its causation and progression. This study assessed levels of leptin and adiponectin in serum and peritoneal fluid (PF) in patients with endometriosis and infertility. DESIGN AND SETTING: This cross-sectional study included women undergoing diagnostic and/or therapeutic laparoscopy for endometriosis with chief complaint of infertility. Following laparoscopy, patients diagnosed with endometriosis served as cases while patients with no endometriosis served as controls. Patients with polycystic ovarian syndrome, diabetes, thyroiditis and patients on prior therapy with danazol or leuprolide were excluded from the study. Leptin and adiponectin levels were analysed in blood and PF using commercially available ELISA kits. RESULTS: Of the 50 patients (aged 22-41 years), 15 had endometriosis (cases) while 35 had no endometriosis (controls). The median PF leptin level was significantly higher in cases as compared to controls (27.7 vs. 15.6 ng/ml, p = 0.019), and this remained significant even when PF leptin was BMI-normalised (p = 0.004). However, median serum leptin and adiponectin levels remained comparable between the two groups. CONCLUSIONS: This study confirmed the role of PF leptin in causation and progression of endometriosis. However, this would have been definitive if healthy fertile females were included in this study. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/20504092/Peritoneal_fluid_leptin_levels_are_increased_but_adiponectin_levels_are_not_changed_in_infertile_patients_with_pelvic_endometriosis_ L2 - http://www.tandfonline.com/doi/full/10.3109/09513590.2010.487585 DB - PRIME DP - Unbound Medicine ER -