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Dietary intake of fish, omega-3, omega-6 polyunsaturated fatty acids and vitamin D and the prevalence of psychotic-like symptoms in a cohort of 33,000 women from the general population.

Abstract

BACKGROUND

Low intake of fish, polyunsaturated fatty acids (PUFA) and vitamin D deficiency has been suggested to play a role in the development of schizophrenia. Our aim was to evaluate the association between the intake of different fish species, PUFA and vitamin D and the prevalence of psychotic-like symptoms in a population-based study among Swedish women.

METHODS

Dietary intake was estimated using a food frequency questionnaire among 33,623 women aged 30-49 years at enrollment (1991/92). Information on psychotic-like symptoms was derived from a follow-up questionnaire in the years 2002/03. Participants were classified into three predefined levels: low, middle and high frequency of symptoms. The association between diet and psychotic-like symptoms was summarized in terms of relative risks (RR) and corresponding 95% confidence intervals and was evaluated by energy-adjusted multinomial logistic regression.

RESULTS

18,411 women were classified as having a low level of psychotic-like symptoms, 14 395 as middle and 817 as having a high level. The risk of high level symptoms was 53% (95% CI, 30-69%) lower among women who ate fish 3-4 times per week compared to women who never ate fish. The risk was also lower for women with a high intake of omega-3 and omega-6 PUFA compared to women with a lower intake of these fatty acids. The effect was most pronounced for omega-6 PUFAs. The RR comparing the highest to the lowest quartile of omega-6 PUFAs intake was 0.78 (95% CI, 0.64-0.97). The associations were J-shaped with the strongest reduced risk for an intermediate intake of fish or PUFA. For fatty fish (herring/mackerel, salmon-type fish), the strongest inverse association was found for an intermediate intake (RR: 0.81, 95% CI, 0.66-0.98), whereas a high intake of fatty fish was associated with an increased risk of psychotic-like symptoms (RR: 1.90, 95% CI, 1.34-2.70). Women in the highest compared with the lowest quartile of vitamin D consumption experienced a 37% (95% CI, 22-50%) lower risk of psychotic-like symptoms.

CONCLUSION

Our findings raise a possibility that adult women with a high intake of fish, omega-3 or omega-6 PUFA and vitamin D have a lower rate of psychotic-like symptoms.

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  • Authors+Show Affiliations

    ,

    Department of Neuroscience, Psychiatry, Ulleråker, Uppsala University, Uppsala, Sweden. maria.hedelin@ki.se

    , , , , ,

    Source

    BMC psychiatry 10: 2010 May 26 pg 38

    MeSH

    Adult
    Animals
    Cohort Studies
    Diet
    Diet Surveys
    Dietary Fats
    Fatty Acids, Omega-3
    Fatty Acids, Omega-6
    Feeding Behavior
    Female
    Fishes
    Humans
    Middle Aged
    Prevalence
    Psychotic Disorders
    Risk Factors
    Schizophrenia
    Seafood
    Surveys and Questionnaires
    Sweden
    Vitamin D

    Pub Type(s)

    Comparative Study
    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20504323

    Citation

    Hedelin, Maria, et al. "Dietary Intake of Fish, Omega-3, Omega-6 Polyunsaturated Fatty Acids and Vitamin D and the Prevalence of Psychotic-like Symptoms in a Cohort of 33,000 Women From the General Population." BMC Psychiatry, vol. 10, 2010, p. 38.
    Hedelin M, Löf M, Olsson M, et al. Dietary intake of fish, omega-3, omega-6 polyunsaturated fatty acids and vitamin D and the prevalence of psychotic-like symptoms in a cohort of 33,000 women from the general population. BMC Psychiatry. 2010;10:38.
    Hedelin, M., Löf, M., Olsson, M., Lewander, T., Nilsson, B., Hultman, C. M., & Weiderpass, E. (2010). Dietary intake of fish, omega-3, omega-6 polyunsaturated fatty acids and vitamin D and the prevalence of psychotic-like symptoms in a cohort of 33,000 women from the general population. BMC Psychiatry, 10, p. 38. doi:10.1186/1471-244X-10-38.
    Hedelin M, et al. Dietary Intake of Fish, Omega-3, Omega-6 Polyunsaturated Fatty Acids and Vitamin D and the Prevalence of Psychotic-like Symptoms in a Cohort of 33,000 Women From the General Population. BMC Psychiatry. 2010 May 26;10:38. PubMed PMID: 20504323.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary intake of fish, omega-3, omega-6 polyunsaturated fatty acids and vitamin D and the prevalence of psychotic-like symptoms in a cohort of 33,000 women from the general population. AU - Hedelin,Maria, AU - Löf,Marie, AU - Olsson,Marita, AU - Lewander,Tommy, AU - Nilsson,Björn, AU - Hultman,Christina M, AU - Weiderpass,Elisabete, Y1 - 2010/05/26/ PY - 2009/12/04/received PY - 2010/05/26/accepted PY - 2010/5/28/entrez PY - 2010/5/28/pubmed PY - 2010/8/3/medline SP - 38 EP - 38 JF - BMC psychiatry JO - BMC Psychiatry VL - 10 N2 - BACKGROUND: Low intake of fish, polyunsaturated fatty acids (PUFA) and vitamin D deficiency has been suggested to play a role in the development of schizophrenia. Our aim was to evaluate the association between the intake of different fish species, PUFA and vitamin D and the prevalence of psychotic-like symptoms in a population-based study among Swedish women. METHODS: Dietary intake was estimated using a food frequency questionnaire among 33,623 women aged 30-49 years at enrollment (1991/92). Information on psychotic-like symptoms was derived from a follow-up questionnaire in the years 2002/03. Participants were classified into three predefined levels: low, middle and high frequency of symptoms. The association between diet and psychotic-like symptoms was summarized in terms of relative risks (RR) and corresponding 95% confidence intervals and was evaluated by energy-adjusted multinomial logistic regression. RESULTS: 18,411 women were classified as having a low level of psychotic-like symptoms, 14 395 as middle and 817 as having a high level. The risk of high level symptoms was 53% (95% CI, 30-69%) lower among women who ate fish 3-4 times per week compared to women who never ate fish. The risk was also lower for women with a high intake of omega-3 and omega-6 PUFA compared to women with a lower intake of these fatty acids. The effect was most pronounced for omega-6 PUFAs. The RR comparing the highest to the lowest quartile of omega-6 PUFAs intake was 0.78 (95% CI, 0.64-0.97). The associations were J-shaped with the strongest reduced risk for an intermediate intake of fish or PUFA. For fatty fish (herring/mackerel, salmon-type fish), the strongest inverse association was found for an intermediate intake (RR: 0.81, 95% CI, 0.66-0.98), whereas a high intake of fatty fish was associated with an increased risk of psychotic-like symptoms (RR: 1.90, 95% CI, 1.34-2.70). Women in the highest compared with the lowest quartile of vitamin D consumption experienced a 37% (95% CI, 22-50%) lower risk of psychotic-like symptoms. CONCLUSION: Our findings raise a possibility that adult women with a high intake of fish, omega-3 or omega-6 PUFA and vitamin D have a lower rate of psychotic-like symptoms. SN - 1471-244X UR - https://www.unboundmedicine.com/medline/citation/20504323/Dietary_intake_of_fish_omega_3_omega_6_polyunsaturated_fatty_acids_and_vitamin_D_and_the_prevalence_of_psychotic_like_symptoms_in_a_cohort_of_33000_women_from_the_general_population_ L2 - https://bmcpsychiatry.biomedcentral.com/articles/10.1186/1471-244X-10-38 DB - PRIME DP - Unbound Medicine ER -