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Plant stanols dose-dependently decrease LDL-cholesterol concentrations, but not cholesterol-standardized fat-soluble antioxidant concentrations, at intakes up to 9 g/d.
Am J Clin Nutr. 2010 Jul; 92(1):24-33.AJ

Abstract

BACKGROUND

It is unclear whether plant stanols lower serum LDL-cholesterol concentrations and cholesterol-standardized fat-soluble antioxidant concentrations dose-dependently when consumption exceeds the recommended daily intakes of 2.0-3.0 g.

OBJECTIVE

The objective was to study the relation between plant stanols provided as plant stanol esters on changes in serum concentrations of LDL cholesterol and fat-soluble antioxidants.

DESIGN

Healthy subjects (n = 93) with slightly elevated serum total cholesterol concentrations (5.0-8.0 mmol/L) received, after a 3-wk run-in period, control products (n = 22) or products (margarine and soy-based yogurt) providing 3 g (n = 24), 6 g (n = 22), or 9 g (n = 25) plant stanols provided as fatty acid esters for 4 wk.

RESULTS

Serum LDL cholesterol decreased dose-dependently. Compared with control, decreases in the 3-g group were 0.32 mmol/L (7.4%; P = 0.005 after adjustment for multiple comparisons). An intake of 6 g plant stanols caused an additional decrease of 0.18 mmol/L (4.5%; P = 0.100 compared with the 3-g group). In the 9-g group, a further decrease of 0.22 mmol/L (5.4%) was observed (P = 0.048 compared with the 6-g group). Serum LDL-cholesterol concentrations were lowered by 17.4% in the 9-g group compared with the control group. No effects on cholesterol-standardized beta-carotene concentrations were observed. Even the change of -0.01 mumol/mmol cholesterol (or -9.2%; P = 0.341) in the 3-g group compared with the control group was not statistically significant because of the large variation in response. Serum HDL-cholesterol and triacylglycerol concentrations, cholesterol-standardized alpha-tocopherol and lutein concentrations, and plasma markers reflecting liver and renal function were not affected.

CONCLUSIONS

Daily consumption of plant stanols up to 9 g reduces serum LDL-cholesterol concentrations linearly up to 17.4%. For cholesterol-standardized fat-soluble antioxidant concentrations, such a relation could not be ascertained.

Authors+Show Affiliations

Department of Human Biology, Maastricht University, Maastricht, Netherlands. r.mensink@hb.unimaas.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20504972

Citation

Mensink, Ronald P., et al. "Plant Stanols Dose-dependently Decrease LDL-cholesterol Concentrations, but Not Cholesterol-standardized Fat-soluble Antioxidant Concentrations, at Intakes Up to 9 G/d." The American Journal of Clinical Nutrition, vol. 92, no. 1, 2010, pp. 24-33.
Mensink RP, de Jong A, Lütjohann D, et al. Plant stanols dose-dependently decrease LDL-cholesterol concentrations, but not cholesterol-standardized fat-soluble antioxidant concentrations, at intakes up to 9 g/d. Am J Clin Nutr. 2010;92(1):24-33.
Mensink, R. P., de Jong, A., Lütjohann, D., Haenen, G. R., & Plat, J. (2010). Plant stanols dose-dependently decrease LDL-cholesterol concentrations, but not cholesterol-standardized fat-soluble antioxidant concentrations, at intakes up to 9 g/d. The American Journal of Clinical Nutrition, 92(1), 24-33. https://doi.org/10.3945/ajcn.2009.29143
Mensink RP, et al. Plant Stanols Dose-dependently Decrease LDL-cholesterol Concentrations, but Not Cholesterol-standardized Fat-soluble Antioxidant Concentrations, at Intakes Up to 9 G/d. Am J Clin Nutr. 2010;92(1):24-33. PubMed PMID: 20504972.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plant stanols dose-dependently decrease LDL-cholesterol concentrations, but not cholesterol-standardized fat-soluble antioxidant concentrations, at intakes up to 9 g/d. AU - Mensink,Ronald P, AU - de Jong,Arienne, AU - Lütjohann,Dieter, AU - Haenen,Guido Rmm, AU - Plat,Jogchum, Y1 - 2010/05/26/ PY - 2010/5/28/entrez PY - 2010/5/28/pubmed PY - 2010/7/8/medline SP - 24 EP - 33 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 92 IS - 1 N2 - BACKGROUND: It is unclear whether plant stanols lower serum LDL-cholesterol concentrations and cholesterol-standardized fat-soluble antioxidant concentrations dose-dependently when consumption exceeds the recommended daily intakes of 2.0-3.0 g. OBJECTIVE: The objective was to study the relation between plant stanols provided as plant stanol esters on changes in serum concentrations of LDL cholesterol and fat-soluble antioxidants. DESIGN: Healthy subjects (n = 93) with slightly elevated serum total cholesterol concentrations (5.0-8.0 mmol/L) received, after a 3-wk run-in period, control products (n = 22) or products (margarine and soy-based yogurt) providing 3 g (n = 24), 6 g (n = 22), or 9 g (n = 25) plant stanols provided as fatty acid esters for 4 wk. RESULTS: Serum LDL cholesterol decreased dose-dependently. Compared with control, decreases in the 3-g group were 0.32 mmol/L (7.4%; P = 0.005 after adjustment for multiple comparisons). An intake of 6 g plant stanols caused an additional decrease of 0.18 mmol/L (4.5%; P = 0.100 compared with the 3-g group). In the 9-g group, a further decrease of 0.22 mmol/L (5.4%) was observed (P = 0.048 compared with the 6-g group). Serum LDL-cholesterol concentrations were lowered by 17.4% in the 9-g group compared with the control group. No effects on cholesterol-standardized beta-carotene concentrations were observed. Even the change of -0.01 mumol/mmol cholesterol (or -9.2%; P = 0.341) in the 3-g group compared with the control group was not statistically significant because of the large variation in response. Serum HDL-cholesterol and triacylglycerol concentrations, cholesterol-standardized alpha-tocopherol and lutein concentrations, and plasma markers reflecting liver and renal function were not affected. CONCLUSIONS: Daily consumption of plant stanols up to 9 g reduces serum LDL-cholesterol concentrations linearly up to 17.4%. For cholesterol-standardized fat-soluble antioxidant concentrations, such a relation could not be ascertained. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/20504972/Plant_stanols_dose_dependently_decrease_LDL_cholesterol_concentrations_but_not_cholesterol_standardized_fat_soluble_antioxidant_concentrations_at_intakes_up_to_9_g/d_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2009.29143 DB - PRIME DP - Unbound Medicine ER -