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Serum nitrosative stress levels are increased in Alzheimer disease but not in vascular dementia.
Alzheimer Dis Assoc Disord. 2010 Apr-Jun; 24(2):194-7.AD

Abstract

The aim of this study was to investigate whether there is a difference between Alzheimer disease (AD) dementia and pure vascular dementia (VaD) in relation to nitrosative stress levels. We determined serum nitric oxide (NO), oxidized low-density lipoproteins (ox-LDL), and 3-nitrotyrosine levels (3-NT) in healthy elderly individuals (controls, n=15, mean age=73.4+/-7.9 y), AD patients (n=30; mean age=71.2+/-12.7 y) and VaD patients (n=20; mean age=75.2+/-7.5 y). Patients were under anticholinesterase drug therapy. Our results showed that serum NO and ox-LDL levels in AD patients group were significantly higher than in both controls (P<0.001 and P<0.001) and VaD patients (P<0.01 and P<0.001). However, no significant differences in plasma NO and ox-LDL levels were found between VaD and controls. Our study did not reveal significant differences in plasma 3-NT values of dementia patients when compared with controls. There was a significant negative correlation between Mini-Mental State Examination score and serum NO levels in dementia patients (r=-0.349, P<0.01). Serum NO levels were also positively correlated with serum ox-LDL levels (r=0.358, P<0.01). In conclusion, elevation in serum levels of NO was present in probable AD patients but not in VaD patients, and this seems to be related to both ox-LDL levels and cognitive status.

Authors+Show Affiliations

Department of Biochemistry, Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey. dkonuk@istanbul.edu.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20505437

Citation

Dildar, Konukoğlu, et al. "Serum Nitrosative Stress Levels Are Increased in Alzheimer Disease but Not in Vascular Dementia." Alzheimer Disease and Associated Disorders, vol. 24, no. 2, 2010, pp. 194-7.
Dildar K, Sinem F, Gökhan E, et al. Serum nitrosative stress levels are increased in Alzheimer disease but not in vascular dementia. Alzheimer Dis Assoc Disord. 2010;24(2):194-7.
Dildar, K., Sinem, F., Gökhan, E., Orhan, Y., & Filiz, M. (2010). Serum nitrosative stress levels are increased in Alzheimer disease but not in vascular dementia. Alzheimer Disease and Associated Disorders, 24(2), 194-7. https://doi.org/10.1097/WAD.0b013e3181c53d0d
Dildar K, et al. Serum Nitrosative Stress Levels Are Increased in Alzheimer Disease but Not in Vascular Dementia. Alzheimer Dis Assoc Disord. 2010 Apr-Jun;24(2):194-7. PubMed PMID: 20505437.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum nitrosative stress levels are increased in Alzheimer disease but not in vascular dementia. AU - Dildar,Konukoğlu, AU - Sinem,Firtina, AU - Gökhan,Erkol, AU - Orhan,Yağiz, AU - Filiz,Manga, PY - 2010/5/28/entrez PY - 2010/5/28/pubmed PY - 2010/8/31/medline SP - 194 EP - 7 JF - Alzheimer disease and associated disorders JO - Alzheimer Dis Assoc Disord VL - 24 IS - 2 N2 - The aim of this study was to investigate whether there is a difference between Alzheimer disease (AD) dementia and pure vascular dementia (VaD) in relation to nitrosative stress levels. We determined serum nitric oxide (NO), oxidized low-density lipoproteins (ox-LDL), and 3-nitrotyrosine levels (3-NT) in healthy elderly individuals (controls, n=15, mean age=73.4+/-7.9 y), AD patients (n=30; mean age=71.2+/-12.7 y) and VaD patients (n=20; mean age=75.2+/-7.5 y). Patients were under anticholinesterase drug therapy. Our results showed that serum NO and ox-LDL levels in AD patients group were significantly higher than in both controls (P<0.001 and P<0.001) and VaD patients (P<0.01 and P<0.001). However, no significant differences in plasma NO and ox-LDL levels were found between VaD and controls. Our study did not reveal significant differences in plasma 3-NT values of dementia patients when compared with controls. There was a significant negative correlation between Mini-Mental State Examination score and serum NO levels in dementia patients (r=-0.349, P<0.01). Serum NO levels were also positively correlated with serum ox-LDL levels (r=0.358, P<0.01). In conclusion, elevation in serum levels of NO was present in probable AD patients but not in VaD patients, and this seems to be related to both ox-LDL levels and cognitive status. SN - 1546-4156 UR - https://www.unboundmedicine.com/medline/citation/20505437/Serum_nitrosative_stress_levels_are_increased_in_Alzheimer_disease_but_not_in_vascular_dementia_ L2 - http://dx.doi.org/10.1097/WAD.0b013e3181c53d0d DB - PRIME DP - Unbound Medicine ER -