Tags

Type your tag names separated by a space and hit enter

From anti-p200 pemphigoid to anti-laminin gamma1 pemphigoid.
J Dermatol. 2010 Mar; 37(3):231-8.JD

Abstract

Anti-laminin gamma1 pemphigoid is an autoimmune subepidermal bullous disease first described in 1996, and has been distinct from previously known subepidermal blistering diseases, such as bullous pemphigoid and epidermolysis bullosa acquisita. Circulating autoantibodies of the patients do not react to any known autoantigen of the skin, but react to a 200-kDa molecule (p200) from dermal extracts. The identity of p200 was unmasked as laminin gamma1, an extracellular matrix glycoprotein composing several forms of laminin heterotrimers. We renamed this disease from the previously used anti-p200 pemphigoid to anti-laminin gamma1 pemphigoid, a new entity of an autoimmune bullous disease. In this decade, we have experienced over 70 cases of this disease. Although the number of the cases of anti-laminin gamma1 pemphigoid is half as many as the number of definitely diagnosed cases of epidermolysis bullosa acquisita in the same duration, a considerable number of the cases could be clinically misdiagnosed as epidermolysis bullosa acquisita. Unveiling the pathogenicity and development of a useful diagnostic method is necessary for appropriate management of this new disease.

Authors+Show Affiliations

Department of Dermatology, Kurume University School of Medicine, Kurume, Fukuoka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20507386

Citation

Dainichi, Teruki, et al. "From Anti-p200 Pemphigoid to Anti-laminin Gamma1 Pemphigoid." The Journal of Dermatology, vol. 37, no. 3, 2010, pp. 231-8.
Dainichi T, Koga H, Tsuji T, et al. From anti-p200 pemphigoid to anti-laminin gamma1 pemphigoid. J Dermatol. 2010;37(3):231-8.
Dainichi, T., Koga, H., Tsuji, T., Ishii, N., Ohyama, B., Ueda, A., Natsuaki, Y., Karashima, T., Nakama, T., Yasumoto, S., Zillikens, D., & Hashimoto, T. (2010). From anti-p200 pemphigoid to anti-laminin gamma1 pemphigoid. The Journal of Dermatology, 37(3), 231-8. https://doi.org/10.1111/j.1346-8138.2009.00793.x
Dainichi T, et al. From Anti-p200 Pemphigoid to Anti-laminin Gamma1 Pemphigoid. J Dermatol. 2010;37(3):231-8. PubMed PMID: 20507386.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - From anti-p200 pemphigoid to anti-laminin gamma1 pemphigoid. AU - Dainichi,Teruki, AU - Koga,Hiroshi, AU - Tsuji,Takako, AU - Ishii,Norito, AU - Ohyama,Bungo, AU - Ueda,Akihiro, AU - Natsuaki,Yohei, AU - Karashima,Tadashi, AU - Nakama,Takekuni, AU - Yasumoto,Shinichiro, AU - Zillikens,Detlef, AU - Hashimoto,Takashi, PY - 2010/5/29/entrez PY - 2010/5/29/pubmed PY - 2010/9/2/medline SP - 231 EP - 8 JF - The Journal of dermatology JO - J Dermatol VL - 37 IS - 3 N2 - Anti-laminin gamma1 pemphigoid is an autoimmune subepidermal bullous disease first described in 1996, and has been distinct from previously known subepidermal blistering diseases, such as bullous pemphigoid and epidermolysis bullosa acquisita. Circulating autoantibodies of the patients do not react to any known autoantigen of the skin, but react to a 200-kDa molecule (p200) from dermal extracts. The identity of p200 was unmasked as laminin gamma1, an extracellular matrix glycoprotein composing several forms of laminin heterotrimers. We renamed this disease from the previously used anti-p200 pemphigoid to anti-laminin gamma1 pemphigoid, a new entity of an autoimmune bullous disease. In this decade, we have experienced over 70 cases of this disease. Although the number of the cases of anti-laminin gamma1 pemphigoid is half as many as the number of definitely diagnosed cases of epidermolysis bullosa acquisita in the same duration, a considerable number of the cases could be clinically misdiagnosed as epidermolysis bullosa acquisita. Unveiling the pathogenicity and development of a useful diagnostic method is necessary for appropriate management of this new disease. SN - 1346-8138 UR - https://www.unboundmedicine.com/medline/citation/20507386/From_anti_p200_pemphigoid_to_anti_laminin_gamma1_pemphigoid_ L2 - https://doi.org/10.1111/j.1346-8138.2009.00793.x DB - PRIME DP - Unbound Medicine ER -