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Infectious crystalline keratopathy caused by Streptococcus Abiotrophia defectiva.
Cornea. 2010 Aug; 29(8):934-6.C

Abstract

PURPOSE

To report the first case of Streptococcus Abiotrophia defectiva-associated crystalline keratopathy.

METHODS

An 83-year-old woman underwent penetrating keratoplasty for pseudophakic bullous keratopathy in the OD. Ten months after surgery, the patient presented with decreased visual acuity in the OD. Slit-lamp examination showed crystalline keratopathy. Corneal scrapings were negative, and the patient was treated empirically with 2 fortified antibiotics (ciprofloxacin and vancomycin). Despite these treatments, the surface of the infiltrate increased and corneal regrafting was performed 6 weeks later. The excised prior graft was evaluated microbiologically [culture and polymerase chain reaction (PCR)] and histopathologically.

RESULTS

In the explanted corneal graft, cultures grew Streptococcus A. defectiva, and its DNA was demonstrated by broad-range PCR (16S ribosomal DNA).

CONCLUSIONS

A. defectiva can be a causative organism of infectious crystalline keratopathy. Risk factors may include long-term corticosteroid use and prior corneal transplantation. The present case confirms that PCR can be a useful technique in the diagnosis of deep infectious keratitis.

Authors+Show Affiliations

Department of Ophthalmology, University Hospital of Strasbourg, Strasbourg, France. florence.abry@chru-strasbourg.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

20508513

Citation

Abry, Florence, et al. "Infectious Crystalline Keratopathy Caused By Streptococcus Abiotrophia Defectiva." Cornea, vol. 29, no. 8, 2010, pp. 934-6.
Abry F, Sauer A, Riegel P, et al. Infectious crystalline keratopathy caused by Streptococcus Abiotrophia defectiva. Cornea. 2010;29(8):934-6.
Abry, F., Sauer, A., Riegel, P., Saleh, M., Gaucher, D., Speeg-Schatz, C., & Bourcier, T. (2010). Infectious crystalline keratopathy caused by Streptococcus Abiotrophia defectiva. Cornea, 29(8), 934-6. https://doi.org/10.1097/ICO.0b013e3181ca2e8f
Abry F, et al. Infectious Crystalline Keratopathy Caused By Streptococcus Abiotrophia Defectiva. Cornea. 2010;29(8):934-6. PubMed PMID: 20508513.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Infectious crystalline keratopathy caused by Streptococcus Abiotrophia defectiva. AU - Abry,Florence, AU - Sauer,Arnaud, AU - Riegel,Philippe, AU - Saleh,Maher, AU - Gaucher,David, AU - Speeg-Schatz,Claude, AU - Bourcier,Tristan, PY - 2010/5/29/entrez PY - 2010/5/29/pubmed PY - 2010/10/5/medline SP - 934 EP - 6 JF - Cornea JO - Cornea VL - 29 IS - 8 N2 - PURPOSE: To report the first case of Streptococcus Abiotrophia defectiva-associated crystalline keratopathy. METHODS: An 83-year-old woman underwent penetrating keratoplasty for pseudophakic bullous keratopathy in the OD. Ten months after surgery, the patient presented with decreased visual acuity in the OD. Slit-lamp examination showed crystalline keratopathy. Corneal scrapings were negative, and the patient was treated empirically with 2 fortified antibiotics (ciprofloxacin and vancomycin). Despite these treatments, the surface of the infiltrate increased and corneal regrafting was performed 6 weeks later. The excised prior graft was evaluated microbiologically [culture and polymerase chain reaction (PCR)] and histopathologically. RESULTS: In the explanted corneal graft, cultures grew Streptococcus A. defectiva, and its DNA was demonstrated by broad-range PCR (16S ribosomal DNA). CONCLUSIONS: A. defectiva can be a causative organism of infectious crystalline keratopathy. Risk factors may include long-term corticosteroid use and prior corneal transplantation. The present case confirms that PCR can be a useful technique in the diagnosis of deep infectious keratitis. SN - 1536-4798 UR - https://www.unboundmedicine.com/medline/citation/20508513/Infectious_crystalline_keratopathy_caused_by_Streptococcus_Abiotrophia_defectiva_ L2 - http://dx.doi.org/10.1097/ICO.0b013e3181ca2e8f DB - PRIME DP - Unbound Medicine ER -