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Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells.
J Cell Physiol. 2010 Oct; 225(1):266-75.JC

Abstract

Dauricine, a bioactive component of Asiatic Moonseed Rhizome, has been widely used to treat a large number of inflammatory diseases in traditional Chinese medicine. In our study, we demonstrated that dauricine inhibited colon cancer cell proliferation and invasion, and induced apoptosis by suppressing nuclear factor-kappaB (NF-kappaB) activation in a dose- and time-dependent manner. Addition of dauricine inhibited the phosphorylation and degradation of IkappaBalpha, and the phosphorylation and translocation of p65. Moreover, dauricine down-regulated the expression of various NF-kappaB-regulated genes, including genes involved cell proliferation (cyclinD1, COX2, and c-Myc), anti-apoptosis (survivin, Bcl-2, XIAP, and IAP1), invasion (MMP-9 and ICAM-1), and angiogenesis (VEGF). In athymic nu/nu mouse model, we further demonstrated that dauricine significantly suppressed colonic tumor growth. Taken together, our results demonstrated that dauricine inhibited colon cancer cell proliferation, invasion, and induced cell apoptosis by suppressing NF-kappaB activity and the expression profile of its downstream genes. These findings provide evidence for a novel role of dauricine in preventing or treating colon cancer through modulation of NF-kappaB singling pathway.

Authors+Show Affiliations

The Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20509140

Citation

Yang, Zhengfeng, et al. "Dauricine Induces Apoptosis, Inhibits Proliferation and Invasion Through Inhibiting NF-kappaB Signaling Pathway in Colon Cancer Cells." Journal of Cellular Physiology, vol. 225, no. 1, 2010, pp. 266-75.
Yang Z, Li C, Wang X, et al. Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells. J Cell Physiol. 2010;225(1):266-75.
Yang, Z., Li, C., Wang, X., Zhai, C., Yi, Z., Wang, L., Liu, B., Du, B., Wu, H., Guo, X., Liu, M., Li, D., & Luo, J. (2010). Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells. Journal of Cellular Physiology, 225(1), 266-75. https://doi.org/10.1002/jcp.22261
Yang Z, et al. Dauricine Induces Apoptosis, Inhibits Proliferation and Invasion Through Inhibiting NF-kappaB Signaling Pathway in Colon Cancer Cells. J Cell Physiol. 2010;225(1):266-75. PubMed PMID: 20509140.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dauricine induces apoptosis, inhibits proliferation and invasion through inhibiting NF-kappaB signaling pathway in colon cancer cells. AU - Yang,Zhengfeng, AU - Li,Chenghai, AU - Wang,Xiu, AU - Zhai,Chunyan, AU - Yi,Zhengfang, AU - Wang,Lei, AU - Liu,Bisheng, AU - Du,Bing, AU - Wu,Huihui, AU - Guo,Xizhi, AU - Liu,Mingyao, AU - Li,Dali, AU - Luo,Jian, PY - 2010/5/29/entrez PY - 2010/5/29/pubmed PY - 2010/9/16/medline SP - 266 EP - 75 JF - Journal of cellular physiology JO - J Cell Physiol VL - 225 IS - 1 N2 - Dauricine, a bioactive component of Asiatic Moonseed Rhizome, has been widely used to treat a large number of inflammatory diseases in traditional Chinese medicine. In our study, we demonstrated that dauricine inhibited colon cancer cell proliferation and invasion, and induced apoptosis by suppressing nuclear factor-kappaB (NF-kappaB) activation in a dose- and time-dependent manner. Addition of dauricine inhibited the phosphorylation and degradation of IkappaBalpha, and the phosphorylation and translocation of p65. Moreover, dauricine down-regulated the expression of various NF-kappaB-regulated genes, including genes involved cell proliferation (cyclinD1, COX2, and c-Myc), anti-apoptosis (survivin, Bcl-2, XIAP, and IAP1), invasion (MMP-9 and ICAM-1), and angiogenesis (VEGF). In athymic nu/nu mouse model, we further demonstrated that dauricine significantly suppressed colonic tumor growth. Taken together, our results demonstrated that dauricine inhibited colon cancer cell proliferation, invasion, and induced cell apoptosis by suppressing NF-kappaB activity and the expression profile of its downstream genes. These findings provide evidence for a novel role of dauricine in preventing or treating colon cancer through modulation of NF-kappaB singling pathway. SN - 1097-4652 UR - https://www.unboundmedicine.com/medline/citation/20509140/Dauricine_induces_apoptosis_inhibits_proliferation_and_invasion_through_inhibiting_NF_kappaB_signaling_pathway_in_colon_cancer_cells_ L2 - https://doi.org/10.1002/jcp.22261 DB - PRIME DP - Unbound Medicine ER -