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Cistaceae aqueous extracts containing ellagitannins show antioxidant and antimicrobial capacity, and cytotoxic activity against human cancer cells.
Food Chem Toxicol. 2010 Aug-Sep; 48(8-9):2273-82.FC

Abstract

Roots and aerial parts of Cistaceae have been used since ancient times in the Mediterranean cultures for its medicinal properties. In this study, phenolic and tannin content of C. ladanifer and C. populifolius leaves aqueous extracts were determined and their antioxidant and antimicrobial activity were fully studied by several in vitro assays. Their major compounds were identified and quantitated by high-performance liquid chromatography with diode array detection coupled to electrospray ion-trap mass spectrometry. Cytotoxicity on a panel of human cancer cells was also determined. C. populifolius extract was stronger antioxidant than C. ladanifer extract in electron transfer reaction based assays but C. ladanifer extract was more effective to inhibit peroxyl radicals. The major compounds in both extracts were ellagitannins, especially punicalagins derivatives, showing C. populifolius a higher content. C. ladanifer showed noteworthy antibacterial activity against Staphylococcus aureus, whereas C. populifolius was effective against Escherichia coli, with MICs values of 154 and 123 microg/mL, respectively. Last, both extracts showed a notorious capacity to inhibit the proliferation of M220 pancreatic cancer cells and MCF7/HER2 and JIMT-1 breast cancer cells. The leaves of these plants suppose a source for water-soluble ellagitannins-enriched polyphenolic extracts with antioxidant and antimicrobial activities. Their cytotoxic activity against several cancer cells may deserve further attention.

Authors+Show Affiliations

Molecular and Cellular Biology Institute, Miguel Hernández University, E-03202 Elche, Alicante, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20510328

Citation

Barrajón-Catalán, Enrique, et al. "Cistaceae Aqueous Extracts Containing Ellagitannins Show Antioxidant and Antimicrobial Capacity, and Cytotoxic Activity Against Human Cancer Cells." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 48, no. 8-9, 2010, pp. 2273-82.
Barrajón-Catalán E, Fernández-Arroyo S, Saura D, et al. Cistaceae aqueous extracts containing ellagitannins show antioxidant and antimicrobial capacity, and cytotoxic activity against human cancer cells. Food Chem Toxicol. 2010;48(8-9):2273-82.
Barrajón-Catalán, E., Fernández-Arroyo, S., Saura, D., Guillén, E., Fernández-Gutiérrez, A., Segura-Carretero, A., & Micol, V. (2010). Cistaceae aqueous extracts containing ellagitannins show antioxidant and antimicrobial capacity, and cytotoxic activity against human cancer cells. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 48(8-9), 2273-82. https://doi.org/10.1016/j.fct.2010.05.060
Barrajón-Catalán E, et al. Cistaceae Aqueous Extracts Containing Ellagitannins Show Antioxidant and Antimicrobial Capacity, and Cytotoxic Activity Against Human Cancer Cells. Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2273-82. PubMed PMID: 20510328.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cistaceae aqueous extracts containing ellagitannins show antioxidant and antimicrobial capacity, and cytotoxic activity against human cancer cells. AU - Barrajón-Catalán,Enrique, AU - Fernández-Arroyo,Salvador, AU - Saura,Domingo, AU - Guillén,Emilio, AU - Fernández-Gutiérrez,Alberto, AU - Segura-Carretero,Antonio, AU - Micol,Vicente, Y1 - 2010/05/25/ PY - 2010/02/17/received PY - 2010/05/05/revised PY - 2010/05/20/accepted PY - 2010/6/1/entrez PY - 2010/6/1/pubmed PY - 2010/11/4/medline SP - 2273 EP - 82 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 48 IS - 8-9 N2 - Roots and aerial parts of Cistaceae have been used since ancient times in the Mediterranean cultures for its medicinal properties. In this study, phenolic and tannin content of C. ladanifer and C. populifolius leaves aqueous extracts were determined and their antioxidant and antimicrobial activity were fully studied by several in vitro assays. Their major compounds were identified and quantitated by high-performance liquid chromatography with diode array detection coupled to electrospray ion-trap mass spectrometry. Cytotoxicity on a panel of human cancer cells was also determined. C. populifolius extract was stronger antioxidant than C. ladanifer extract in electron transfer reaction based assays but C. ladanifer extract was more effective to inhibit peroxyl radicals. The major compounds in both extracts were ellagitannins, especially punicalagins derivatives, showing C. populifolius a higher content. C. ladanifer showed noteworthy antibacterial activity against Staphylococcus aureus, whereas C. populifolius was effective against Escherichia coli, with MICs values of 154 and 123 microg/mL, respectively. Last, both extracts showed a notorious capacity to inhibit the proliferation of M220 pancreatic cancer cells and MCF7/HER2 and JIMT-1 breast cancer cells. The leaves of these plants suppose a source for water-soluble ellagitannins-enriched polyphenolic extracts with antioxidant and antimicrobial activities. Their cytotoxic activity against several cancer cells may deserve further attention. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/20510328/Cistaceae_aqueous_extracts_containing_ellagitannins_show_antioxidant_and_antimicrobial_capacity_and_cytotoxic_activity_against_human_cancer_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(10)00339-X DB - PRIME DP - Unbound Medicine ER -