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Investigation of fruit peel extracts as sources for compounds with antioxidant and antiproliferative activities against human cell lines.
Food Chem Toxicol. 2010 Aug-Sep; 48(8-9):2122-9.FC

Abstract

The aim of this study was to evaluate antioxidant activity and cytotoxicity against human cell lines of fruit peel extracts from rambutan, mangosteen and coconut. The highest antioxidant activity was found from rambutan peel crude extract where the highest radical scavenging capacity via ABTS assay was from its ethyl acetate fraction with a TEAC value of 23.0mM/mg and the highest ferric ion reduction activity via FRAP assay was from its methanol fraction with an EC value of 20.2mM/mg. Importantly, using both assays, these fractions had a higher antioxidant activity than butylated hydroxyl toluene and vitamin E. It was shown that the ethyl acetate fraction of rambutan peel had the highest polyphenolic content with a gallic acid equivalent of 2.3mg/mL. The results indicate that the polyphenolic compounds are responsible for the observed antioxidant activity of the extracts. Interestingly, the hexane fraction of coconut peel showed a potent cytotoxic effect on KB cell line by MTT assay (IC(50)=7.7 microg/mL), and no detectable cytotoxicity toward normal cells. We concluded that the ethyl acetate fraction of rambutan peel is a promising resource for potential novel antioxidant agents whereas the hexane fraction of coconut peel may contain novel anticancer compounds.

Authors+Show Affiliations

Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20510336

Citation

Khonkarn, Ruttiros, et al. "Investigation of Fruit Peel Extracts as Sources for Compounds With Antioxidant and Antiproliferative Activities Against Human Cell Lines." Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, vol. 48, no. 8-9, 2010, pp. 2122-9.
Khonkarn R, Okonogi S, Ampasavate C, et al. Investigation of fruit peel extracts as sources for compounds with antioxidant and antiproliferative activities against human cell lines. Food Chem Toxicol. 2010;48(8-9):2122-9.
Khonkarn, R., Okonogi, S., Ampasavate, C., & Anuchapreeda, S. (2010). Investigation of fruit peel extracts as sources for compounds with antioxidant and antiproliferative activities against human cell lines. Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association, 48(8-9), 2122-9. https://doi.org/10.1016/j.fct.2010.05.014
Khonkarn R, et al. Investigation of Fruit Peel Extracts as Sources for Compounds With Antioxidant and Antiproliferative Activities Against Human Cell Lines. Food Chem Toxicol. 2010 Aug-Sep;48(8-9):2122-9. PubMed PMID: 20510336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Investigation of fruit peel extracts as sources for compounds with antioxidant and antiproliferative activities against human cell lines. AU - Khonkarn,Ruttiros, AU - Okonogi,Siriporn, AU - Ampasavate,Chadarat, AU - Anuchapreeda,Songyot, Y1 - 2010/05/25/ PY - 2010/02/06/received PY - 2010/04/11/revised PY - 2010/05/07/accepted PY - 2010/6/1/entrez PY - 2010/6/1/pubmed PY - 2010/11/4/medline SP - 2122 EP - 9 JF - Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association JO - Food Chem. Toxicol. VL - 48 IS - 8-9 N2 - The aim of this study was to evaluate antioxidant activity and cytotoxicity against human cell lines of fruit peel extracts from rambutan, mangosteen and coconut. The highest antioxidant activity was found from rambutan peel crude extract where the highest radical scavenging capacity via ABTS assay was from its ethyl acetate fraction with a TEAC value of 23.0mM/mg and the highest ferric ion reduction activity via FRAP assay was from its methanol fraction with an EC value of 20.2mM/mg. Importantly, using both assays, these fractions had a higher antioxidant activity than butylated hydroxyl toluene and vitamin E. It was shown that the ethyl acetate fraction of rambutan peel had the highest polyphenolic content with a gallic acid equivalent of 2.3mg/mL. The results indicate that the polyphenolic compounds are responsible for the observed antioxidant activity of the extracts. Interestingly, the hexane fraction of coconut peel showed a potent cytotoxic effect on KB cell line by MTT assay (IC(50)=7.7 microg/mL), and no detectable cytotoxicity toward normal cells. We concluded that the ethyl acetate fraction of rambutan peel is a promising resource for potential novel antioxidant agents whereas the hexane fraction of coconut peel may contain novel anticancer compounds. SN - 1873-6351 UR - https://www.unboundmedicine.com/medline/citation/20510336/Investigation_of_fruit_peel_extracts_as_sources_for_compounds_with_antioxidant_and_antiproliferative_activities_against_human_cell_lines_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-6915(10)00290-5 DB - PRIME DP - Unbound Medicine ER -