Tags

Type your tag names separated by a space and hit enter

Pancreatic enzyme replacement therapy in chronic pancreatitis.
Best Pract Res Clin Gastroenterol. 2010 Jun; 24(3):337-47.BP

Abstract

Exocrine pancreatic insufficiency (EPI) is a serious condition which occurs in several diseases including chronic pancreatitis (CP), cystic fibrosis, pancreatic cancer, and as a result of pancreatic surgery. The lack or absence of pancreatic enzymes leads to an inadequate absorption of fat, proteins, and carbohydrates, causing steatorrhoea and creathorrhea which results in abdominal discomfort, weight loss, and nutritional deficiencies. To avoid malnutrition related morbidity and mortality, it is pivotal to commence pancreatic enzyme replacement therapy (PERT) as soon as EPI is diagnosed. Factors as early acidic inactivation of ingested enzymes, under dosage, and patient incompliance may prevent normalisation of nutrient absorption, in particular of fat digestion. This review focuses on the current status of how to diagnose and treat EPI.

Authors+Show Affiliations

Department of Gastroenterology and Hepatology, Erasmus Medical Center, Rotterdam, The Netherlands. e.sikkens@erasmusmc.nl <e.sikkens@erasmusmc.nl>No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

20510833

Citation

Sikkens, E C M., et al. "Pancreatic Enzyme Replacement Therapy in Chronic Pancreatitis." Best Practice & Research. Clinical Gastroenterology, vol. 24, no. 3, 2010, pp. 337-47.
Sikkens EC, Cahen DL, Kuipers EJ, et al. Pancreatic enzyme replacement therapy in chronic pancreatitis. Best Pract Res Clin Gastroenterol. 2010;24(3):337-47.
Sikkens, E. C., Cahen, D. L., Kuipers, E. J., & Bruno, M. J. (2010). Pancreatic enzyme replacement therapy in chronic pancreatitis. Best Practice & Research. Clinical Gastroenterology, 24(3), 337-47. https://doi.org/10.1016/j.bpg.2010.03.006
Sikkens EC, et al. Pancreatic Enzyme Replacement Therapy in Chronic Pancreatitis. Best Pract Res Clin Gastroenterol. 2010;24(3):337-47. PubMed PMID: 20510833.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pancreatic enzyme replacement therapy in chronic pancreatitis. AU - Sikkens,E C M, AU - Cahen,D L, AU - Kuipers,E J, AU - Bruno,M J, PY - 2010/02/12/received PY - 2010/03/16/revised PY - 2010/03/16/accepted PY - 2010/6/1/entrez PY - 2010/6/1/pubmed PY - 2010/9/4/medline SP - 337 EP - 47 JF - Best practice & research. Clinical gastroenterology JO - Best Pract Res Clin Gastroenterol VL - 24 IS - 3 N2 - Exocrine pancreatic insufficiency (EPI) is a serious condition which occurs in several diseases including chronic pancreatitis (CP), cystic fibrosis, pancreatic cancer, and as a result of pancreatic surgery. The lack or absence of pancreatic enzymes leads to an inadequate absorption of fat, proteins, and carbohydrates, causing steatorrhoea and creathorrhea which results in abdominal discomfort, weight loss, and nutritional deficiencies. To avoid malnutrition related morbidity and mortality, it is pivotal to commence pancreatic enzyme replacement therapy (PERT) as soon as EPI is diagnosed. Factors as early acidic inactivation of ingested enzymes, under dosage, and patient incompliance may prevent normalisation of nutrient absorption, in particular of fat digestion. This review focuses on the current status of how to diagnose and treat EPI. SN - 1532-1916 UR - https://www.unboundmedicine.com/medline/citation/20510833/Pancreatic_enzyme_replacement_therapy_in_chronic_pancreatitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1521-6918(10)00040-5 DB - PRIME DP - Unbound Medicine ER -