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[The sebaceous gland].
Hautarzt. 2010 Jun; 61(6):467-8, 4704, 476-7.H

Abstract

The development and function of the sebaceous gland in the fetal and neonatal periods appear to be regulated by maternal androgens and by endogenous steroid synthesis, as well as by other morphogens. The most apparent function of the glands is to excrete sebum. A strong increase in sebum excretion occurs a few hours after birth; this peaks during the first week and slowly subsides thereafter. A new rise takes place at about age 9 years with adrenarche and continues up to age 17 years, when the adult level is reached. The sebaceous gland is a target organ but also an important formation site of hormones, and especially of active androgens. Hormonal activity is based on an hormone (ligand)-receptor interaction, whereas sebocytes express a wide spectrum of hormone receptors. Androgens are well known for their effects on sebum excretion, whereas terminal sebocyte differentiation is assisted by peroxisome proliferator-activated receptor ligands. Estrogens, glucocorticoids, and prolactin also influence sebaceous gland function. In addition, stress-sensing cutaneous signals lead to the production and release of corticotrophin-releasing hormone from dermal nerves and sebocytes with subsequent dose-dependent regulation of sebaceous nonpolar lipids. Among other lipid fractions, sebaceous glands have been shown to synthesize considerable amounts of free fatty acids without exogenous influence. Atopic dermatitis, seborrheic dermatitis, psoriasis and acne vulgaris are some of the disease on which pathogenesis and severity sebaceous lipids may or are surely involved.

Authors+Show Affiliations

Klinik für Dermatologie, Venerologie und Allergologie / Immunologisches Zentrum, Städtisches Klinikum Dessau, Auenweg 38, 06847, Dessau, Germany. christos.zouboulis@klinikum-dessau.de

Pub Type(s)

Journal Article
Review

Language

ger

PubMed ID

20512305

Citation

Zouboulis, C C.. "[The Sebaceous Gland]." Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete, vol. 61, no. 6, 2010, pp. 467-8, 4704, 476-7.
Zouboulis CC. [The sebaceous gland]. Hautarzt. 2010;61(6):467-8, 4704, 476-7.
Zouboulis, C. C. (2010). [The sebaceous gland]. Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete, 61(6), 467-8, 4704, 476-7. https://doi.org/10.1007/s00105-009-1894-y
Zouboulis CC. [The Sebaceous Gland]. Hautarzt. 2010;61(6):467-8, 4704, 476-7. PubMed PMID: 20512305.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The sebaceous gland]. A1 - Zouboulis,C C, PY - 2010/6/1/entrez PY - 2010/6/1/pubmed PY - 2010/11/10/medline SP - 467-8, 4704, 476-7 JF - Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete JO - Hautarzt VL - 61 IS - 6 N2 - The development and function of the sebaceous gland in the fetal and neonatal periods appear to be regulated by maternal androgens and by endogenous steroid synthesis, as well as by other morphogens. The most apparent function of the glands is to excrete sebum. A strong increase in sebum excretion occurs a few hours after birth; this peaks during the first week and slowly subsides thereafter. A new rise takes place at about age 9 years with adrenarche and continues up to age 17 years, when the adult level is reached. The sebaceous gland is a target organ but also an important formation site of hormones, and especially of active androgens. Hormonal activity is based on an hormone (ligand)-receptor interaction, whereas sebocytes express a wide spectrum of hormone receptors. Androgens are well known for their effects on sebum excretion, whereas terminal sebocyte differentiation is assisted by peroxisome proliferator-activated receptor ligands. Estrogens, glucocorticoids, and prolactin also influence sebaceous gland function. In addition, stress-sensing cutaneous signals lead to the production and release of corticotrophin-releasing hormone from dermal nerves and sebocytes with subsequent dose-dependent regulation of sebaceous nonpolar lipids. Among other lipid fractions, sebaceous glands have been shown to synthesize considerable amounts of free fatty acids without exogenous influence. Atopic dermatitis, seborrheic dermatitis, psoriasis and acne vulgaris are some of the disease on which pathogenesis and severity sebaceous lipids may or are surely involved. SN - 1432-1173 UR - https://www.unboundmedicine.com/medline/citation/20512305/[The_sebaceous_gland]_ L2 - https://dx.doi.org/10.1007/s00105-009-1894-y DB - PRIME DP - Unbound Medicine ER -