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Molecular and serological survey of hepatitis E virus infection among domestic pigs in Inner Mongolia, China.
Arch Virol. 2010 Aug; 155(8):1217-26.AV

Abstract

To evaluate the prevalence and characteristics of swine hepatitis E virus (HEV) infection in Inner Mongolia, China, serum samples obtained from 356 2- to 4-month-old pigs on 14 farms in Inner Mongolia were tested for the presence of anti-HEV antibodies and HEV RNA. Overall, 186 pigs (52%) tested positive for anti-HEV antibodies, while 30 pigs (8%) had detectable HEV RNA levels. The 30 HEV isolates recovered from the viremic pigs were phylogenetically classified into genotype 4 and differed from each other by up to 15.3% in a 412 nt sequence within ORF2. The Inner Mongolian swine HEV strains were most similar to human or swine HEV strains isolated in the other provinces of China but differed by 15.9-18.9% from those in Mongolia (formerly known as Outer Mongolia). These results indicate that farm pigs in Inner Mongolia are frequently infected with markedly divergent genotype 4 HEV strains that may be indigenous to China.

Authors+Show Affiliations

College of Veterinary Medicine, Inner Mongolia Agriculture University, Hohhot, Inner Mongolia, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20512514

Citation

Jinshan, , et al. "Molecular and Serological Survey of Hepatitis E Virus Infection Among Domestic Pigs in Inner Mongolia, China." Archives of Virology, vol. 155, no. 8, 2010, pp. 1217-26.
Jinshan , Jirintai , Manglai D, et al. Molecular and serological survey of hepatitis E virus infection among domestic pigs in Inner Mongolia, China. Arch Virol. 2010;155(8):1217-26.
Jinshan, ., Jirintai, ., Manglai, D., Takahashi, M., Nagashima, S., & Okamoto, H. (2010). Molecular and serological survey of hepatitis E virus infection among domestic pigs in Inner Mongolia, China. Archives of Virology, 155(8), 1217-26. https://doi.org/10.1007/s00705-010-0706-0
Jinshan , et al. Molecular and Serological Survey of Hepatitis E Virus Infection Among Domestic Pigs in Inner Mongolia, China. Arch Virol. 2010;155(8):1217-26. PubMed PMID: 20512514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular and serological survey of hepatitis E virus infection among domestic pigs in Inner Mongolia, China. AU - Jinshan,, AU - Jirintai,, AU - Manglai,Dugarjavin, AU - Takahashi,Masaharu, AU - Nagashima,Shigeo, AU - Okamoto,Hiroaki, Y1 - 2010/05/29/ PY - 2010/03/23/received PY - 2010/04/30/accepted PY - 2010/6/1/entrez PY - 2010/6/1/pubmed PY - 2010/9/3/medline SP - 1217 EP - 26 JF - Archives of virology JO - Arch Virol VL - 155 IS - 8 N2 - To evaluate the prevalence and characteristics of swine hepatitis E virus (HEV) infection in Inner Mongolia, China, serum samples obtained from 356 2- to 4-month-old pigs on 14 farms in Inner Mongolia were tested for the presence of anti-HEV antibodies and HEV RNA. Overall, 186 pigs (52%) tested positive for anti-HEV antibodies, while 30 pigs (8%) had detectable HEV RNA levels. The 30 HEV isolates recovered from the viremic pigs were phylogenetically classified into genotype 4 and differed from each other by up to 15.3% in a 412 nt sequence within ORF2. The Inner Mongolian swine HEV strains were most similar to human or swine HEV strains isolated in the other provinces of China but differed by 15.9-18.9% from those in Mongolia (formerly known as Outer Mongolia). These results indicate that farm pigs in Inner Mongolia are frequently infected with markedly divergent genotype 4 HEV strains that may be indigenous to China. SN - 1432-8798 UR - https://www.unboundmedicine.com/medline/citation/20512514/Molecular_and_serological_survey_of_hepatitis_E_virus_infection_among_domestic_pigs_in_Inner_Mongolia_China_ L2 - https://dx.doi.org/10.1007/s00705-010-0706-0 DB - PRIME DP - Unbound Medicine ER -