Tags

Type your tag names separated by a space and hit enter

Factors associated with death in hospitalized pneumonia patients with 2009 H1N1 influenza in Shenyang, China.
BMC Infect Dis. 2010 May 31; 10:145.BI

Abstract

BACKGROUND

During the spring of 2009, a pandemic influenza A (H1N1) virus emerged and spread globally. We describe the clinical characteristics and factors associated with the death of patients who were hospitalized with 2009 H1N1 influenza pneumonia in Shenyang, China, from November to December 2009.

METHODS

We carried out a retrospective chart review of 68 patients who were hospitalized with pneumonia and confirmed to have 2009 H1N1 virus infection by a real time RT-PCR assay of respiratory specimens.

RESULTS

Of the 68 patients we studied, 30 (44%) were admitted to an intensive care unit and 10 (14.7%) died. The median age of patients was 41 years (range, 18-66), and only one patient was over 65 years of age. The male to female ratio was 2.78:1 (50:18). Of the 68 patients, 23 (34%) had at least one underlying medical condition, 9 (13%) had a cigarette index > or =400 and 22 (32%) were obese. All patients underwent chest radiography on admission and the findings were consistent with pneumonia in all cases. All patients were treated with oseltamivir and treatment was initiated at a median time of seven days after the onset of illness. The laboratory test results indicated lymphopenia, hypoproteinemia and elevated lactic dehydrogenase and C reactive protein levels. Of the 68 patients, 33 (52%) showed a reduction in CD4 T cell counts. Of the 58 patients who survived, 31 (53%) had lymphopenia and 27 recovered from this condition after five days. Of the 10 patients who died, nine (90%) had lymphopenia and only two patients recovered from this condition after five days. Obesity and recovery from lymphopenia after five days were factors associated with death, as determined by multivariate logistic-regression analysis (obesity, odds ratio = 23.06; lymphocytopenia reversion, odds ration = 28.69).

CONCLUSIONS

During the evaluation period in Shenyang, China, 2009 H1N1 influenza caused severe illness requiring hospitalization in 68 patients, 10 (14.7%) of which died. Many of these patients were considered healthy adults and few were elderly (65 years or older). Obesity and lymphopenia, which was not restored after five days of treatment, were factors associated with poor outcomes of 2009 H1N1 influenza infection.

Authors+Show Affiliations

Department of Infectious Diseases, the First Affiliated Hospital, China Medical University, Shenyang, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20513239

Citation

Cui, Wei, et al. "Factors Associated With Death in Hospitalized Pneumonia Patients With 2009 H1N1 Influenza in Shenyang, China." BMC Infectious Diseases, vol. 10, 2010, p. 145.
Cui W, Zhao H, Lu X, et al. Factors associated with death in hospitalized pneumonia patients with 2009 H1N1 influenza in Shenyang, China. BMC Infect Dis. 2010;10:145.
Cui, W., Zhao, H., Lu, X., Wen, Y., Zhou, Y., Deng, B., Wang, Y., Wang, W., Kang, J., & Liu, P. (2010). Factors associated with death in hospitalized pneumonia patients with 2009 H1N1 influenza in Shenyang, China. BMC Infectious Diseases, 10, 145. https://doi.org/10.1186/1471-2334-10-145
Cui W, et al. Factors Associated With Death in Hospitalized Pneumonia Patients With 2009 H1N1 Influenza in Shenyang, China. BMC Infect Dis. 2010 May 31;10:145. PubMed PMID: 20513239.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Factors associated with death in hospitalized pneumonia patients with 2009 H1N1 influenza in Shenyang, China. AU - Cui,Wei, AU - Zhao,Hongwen, AU - Lu,Xu, AU - Wen,Ying, AU - Zhou,Ying, AU - Deng,Baocheng, AU - Wang,Yu, AU - Wang,Wen, AU - Kang,Jian, AU - Liu,Pei, Y1 - 2010/05/31/ PY - 2010/01/07/received PY - 2010/05/31/accepted PY - 2010/6/2/entrez PY - 2010/6/2/pubmed PY - 2010/7/16/medline SP - 145 EP - 145 JF - BMC infectious diseases JO - BMC Infect. Dis. VL - 10 N2 - BACKGROUND: During the spring of 2009, a pandemic influenza A (H1N1) virus emerged and spread globally. We describe the clinical characteristics and factors associated with the death of patients who were hospitalized with 2009 H1N1 influenza pneumonia in Shenyang, China, from November to December 2009. METHODS: We carried out a retrospective chart review of 68 patients who were hospitalized with pneumonia and confirmed to have 2009 H1N1 virus infection by a real time RT-PCR assay of respiratory specimens. RESULTS: Of the 68 patients we studied, 30 (44%) were admitted to an intensive care unit and 10 (14.7%) died. The median age of patients was 41 years (range, 18-66), and only one patient was over 65 years of age. The male to female ratio was 2.78:1 (50:18). Of the 68 patients, 23 (34%) had at least one underlying medical condition, 9 (13%) had a cigarette index > or =400 and 22 (32%) were obese. All patients underwent chest radiography on admission and the findings were consistent with pneumonia in all cases. All patients were treated with oseltamivir and treatment was initiated at a median time of seven days after the onset of illness. The laboratory test results indicated lymphopenia, hypoproteinemia and elevated lactic dehydrogenase and C reactive protein levels. Of the 68 patients, 33 (52%) showed a reduction in CD4 T cell counts. Of the 58 patients who survived, 31 (53%) had lymphopenia and 27 recovered from this condition after five days. Of the 10 patients who died, nine (90%) had lymphopenia and only two patients recovered from this condition after five days. Obesity and recovery from lymphopenia after five days were factors associated with death, as determined by multivariate logistic-regression analysis (obesity, odds ratio = 23.06; lymphocytopenia reversion, odds ration = 28.69). CONCLUSIONS: During the evaluation period in Shenyang, China, 2009 H1N1 influenza caused severe illness requiring hospitalization in 68 patients, 10 (14.7%) of which died. Many of these patients were considered healthy adults and few were elderly (65 years or older). Obesity and lymphopenia, which was not restored after five days of treatment, were factors associated with poor outcomes of 2009 H1N1 influenza infection. SN - 1471-2334 UR - https://www.unboundmedicine.com/medline/citation/20513239/Factors_associated_with_death_in_hospitalized_pneumonia_patients_with_2009_H1N1_influenza_in_Shenyang_China_ L2 - https://bmcinfectdis.biomedcentral.com/articles/10.1186/1471-2334-10-145 DB - PRIME DP - Unbound Medicine ER -