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Synthesis of beta- and gamma-carbolinones via Pd-catalyzed direct dehydrogenative annulation (DDA) of indole-carboxamides with alkynes using air as the oxidant.
Org Lett. 2010 Jul 02; 12(13):2908-11.OL

Abstract

A palladium-catalyzed direct dehydrogenative annulation (DDA) of indolecarboxamides with internal alkynes via C-H and N-H bond cleavage using air as the oxidant was developed. With this method, both beta- and gamma-carbolinones can be easily prepared under the mild conditions.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Shi Z
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Xue Yuan Road 38, Beijing 100083, China.
Cui Y
No affiliation info available
Jiao N
No affiliation info available

MeSH

AlkynesAmidesCarbolinesCatalysisHydrogenationIndolesMolecular StructureOrganometallic CompoundsOxidantsOxidation-ReductionPalladiumStereoisomerism

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20515016

Citation

Shi, Zhuangzhi, et al. "Synthesis of Beta- and Gamma-carbolinones Via Pd-catalyzed Direct Dehydrogenative Annulation (DDA) of Indole-carboxamides With Alkynes Using Air as the Oxidant." Organic Letters, vol. 12, no. 13, 2010, pp. 2908-11.
Shi Z, Cui Y, Jiao N. Synthesis of beta- and gamma-carbolinones via Pd-catalyzed direct dehydrogenative annulation (DDA) of indole-carboxamides with alkynes using air as the oxidant. Org Lett. 2010;12(13):2908-11.
Shi, Z., Cui, Y., & Jiao, N. (2010). Synthesis of beta- and gamma-carbolinones via Pd-catalyzed direct dehydrogenative annulation (DDA) of indole-carboxamides with alkynes using air as the oxidant. Organic Letters, 12(13), 2908-11. https://doi.org/10.1021/ol1007839
Shi Z, Cui Y, Jiao N. Synthesis of Beta- and Gamma-carbolinones Via Pd-catalyzed Direct Dehydrogenative Annulation (DDA) of Indole-carboxamides With Alkynes Using Air as the Oxidant. Org Lett. 2010 Jul 2;12(13):2908-11. PubMed PMID: 20515016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis of beta- and gamma-carbolinones via Pd-catalyzed direct dehydrogenative annulation (DDA) of indole-carboxamides with alkynes using air as the oxidant. AU - Shi,Zhuangzhi, AU - Cui,Yuxin, AU - Jiao,Ning, PY - 2010/6/3/entrez PY - 2010/6/3/pubmed PY - 2010/9/21/medline SP - 2908 EP - 11 JF - Organic letters JO - Org Lett VL - 12 IS - 13 N2 - A palladium-catalyzed direct dehydrogenative annulation (DDA) of indolecarboxamides with internal alkynes via C-H and N-H bond cleavage using air as the oxidant was developed. With this method, both beta- and gamma-carbolinones can be easily prepared under the mild conditions. SN - 1523-7052 UR - https://www.unboundmedicine.com/medline/citation/20515016/Synthesis_of_beta__and_gamma_carbolinones_via_Pd_catalyzed_direct_dehydrogenative_annulation__DDA__of_indole_carboxamides_with_alkynes_using_air_as_the_oxidant_ L2 - https://doi.org/10.1021/ol1007839 DB - PRIME DP - Unbound Medicine ER -