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Serum glycated albumin to haemoglobin A(1C) ratio can distinguish fulminant type 1 diabetes mellitus from type 2 diabetes mellitus.
Ann Clin Biochem. 2010 Jul; 47(Pt 4):313-7.AC

Abstract

BACKGROUND

Fulminant type 1 diabetes mellitus (FT1DM), a subtype of type 1 diabetes mellitus, was first reported as a disease entity in 2000. Ketoacidosis at initial onset due to acute pancreatic cell destruction makes early diagnosis and treatment for FT1DM mandatory. In the early period of FT1DM, haemoglobin (Hb)A(1C) levels are not markedly elevated. This study investigated serum glycated albumin (GA), which reflects acute short-term changes in plasma glucose, as a new clinical index for FT1DM at disease onset.

METHODS

Subjects comprised 35 patients with FT1DM who had undergone measurement of HbA(1C) and serum GA at initial visit and 42 patients with type 2 diabetes mellitus (T2DM) with HbA(1C) <8.5% and no history of diabetes treatment as controls.

RESULTS

HbA(1C) was significantly lower in FT1DM than in T2DM, whereas serum GA was significantly higher. GA/HbA(1C) ratio was thus significantly higher in FT1DM than in T2DM (3.9 +/- 0.5 versus 2.8 +/- 0.3; P < 0.0001). GA/HbA(1C) ratio was >3.2 in 41 of 42 FT1DM patients (98%), compared with only one of 32 T2DM patients (3%).

CONCLUSIONS

Serum GA is significantly higher in FT1DM than in T2DM, whereas HbA(1C) is significantly lower. FT1DM can thus be distinguished from untreated T2DM by GA/HbA(1C) ratio at initial visit before treatment for diabetes.

Authors+Show Affiliations

Department of Internal Medicine, Kinki Central Hospital, Hyogo 664-8533, Japan. koga_m@kich.itami.hyogo.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20516001

Citation

Koga, Masafumi, et al. "Serum Glycated Albumin to Haemoglobin A(1C) Ratio Can Distinguish Fulminant Type 1 Diabetes Mellitus From Type 2 Diabetes Mellitus." Annals of Clinical Biochemistry, vol. 47, no. Pt 4, 2010, pp. 313-7.
Koga M, Murai J, Saito H, et al. Serum glycated albumin to haemoglobin A(1C) ratio can distinguish fulminant type 1 diabetes mellitus from type 2 diabetes mellitus. Ann Clin Biochem. 2010;47(Pt 4):313-7.
Koga, M., Murai, J., Saito, H., Kasayama, S., Imagawa, A., Hanafusa, T., & Kobayashi, T. (2010). Serum glycated albumin to haemoglobin A(1C) ratio can distinguish fulminant type 1 diabetes mellitus from type 2 diabetes mellitus. Annals of Clinical Biochemistry, 47(Pt 4), 313-7. https://doi.org/10.1258/acb.2010.009234
Koga M, et al. Serum Glycated Albumin to Haemoglobin A(1C) Ratio Can Distinguish Fulminant Type 1 Diabetes Mellitus From Type 2 Diabetes Mellitus. Ann Clin Biochem. 2010;47(Pt 4):313-7. PubMed PMID: 20516001.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum glycated albumin to haemoglobin A(1C) ratio can distinguish fulminant type 1 diabetes mellitus from type 2 diabetes mellitus. AU - Koga,Masafumi, AU - Murai,Jun, AU - Saito,Hiroshi, AU - Kasayama,Soji, AU - Imagawa,Akihisa, AU - Hanafusa,Toshiaki, AU - Kobayashi,Tetsuro, AU - ,, Y1 - 2010/06/01/ PY - 2010/6/3/entrez PY - 2010/6/3/pubmed PY - 2011/10/1/medline SP - 313 EP - 7 JF - Annals of clinical biochemistry JO - Ann Clin Biochem VL - 47 IS - Pt 4 N2 - BACKGROUND: Fulminant type 1 diabetes mellitus (FT1DM), a subtype of type 1 diabetes mellitus, was first reported as a disease entity in 2000. Ketoacidosis at initial onset due to acute pancreatic cell destruction makes early diagnosis and treatment for FT1DM mandatory. In the early period of FT1DM, haemoglobin (Hb)A(1C) levels are not markedly elevated. This study investigated serum glycated albumin (GA), which reflects acute short-term changes in plasma glucose, as a new clinical index for FT1DM at disease onset. METHODS: Subjects comprised 35 patients with FT1DM who had undergone measurement of HbA(1C) and serum GA at initial visit and 42 patients with type 2 diabetes mellitus (T2DM) with HbA(1C) <8.5% and no history of diabetes treatment as controls. RESULTS: HbA(1C) was significantly lower in FT1DM than in T2DM, whereas serum GA was significantly higher. GA/HbA(1C) ratio was thus significantly higher in FT1DM than in T2DM (3.9 +/- 0.5 versus 2.8 +/- 0.3; P < 0.0001). GA/HbA(1C) ratio was >3.2 in 41 of 42 FT1DM patients (98%), compared with only one of 32 T2DM patients (3%). CONCLUSIONS: Serum GA is significantly higher in FT1DM than in T2DM, whereas HbA(1C) is significantly lower. FT1DM can thus be distinguished from untreated T2DM by GA/HbA(1C) ratio at initial visit before treatment for diabetes. SN - 1758-1001 UR - https://www.unboundmedicine.com/medline/citation/20516001/Serum_glycated_albumin_to_haemoglobin_A_1C__ratio_can_distinguish_fulminant_type_1_diabetes_mellitus_from_type_2_diabetes_mellitus_ L2 - https://journals.sagepub.com/doi/10.1258/acb.2010.009234?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -