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Calcium intake increases risk of prostate cancer among Singapore Chinese.
Cancer Res. 2010 Jun 15; 70(12):4941-8.CR

Abstract

Consumption of dairy products, the primary source of calcium in Western diets, has been found to be positively associated with prostate cancer. In an Asian diet, nondairy foods are the major contributors of calcium. Thus, a study of dietary calcium and prostate cancer in Asians can better inform on whether calcium, as opposed to other dairy components, is responsible for the dairy foods-prostate cancer association. We examined calcium intake and prostate cancer risk among 27,293 men in the Singapore Chinese Health Study that was established between 1993 and 1998. As of December 31, 2007, 298 incident prostate cancer cases had been diagnosed among the cohort members. Diet was assessed at baseline with a validated 165-item food-frequency questionnaire. It is hypothesized that there is greater net absorption of calcium in smaller individuals. Therefore, the calcium-prostate cancer association was also assessed in stratified analyses by median body mass index. Vegetables were the largest contributor of daily calcium intake in the study population. Overall, we observed a modest, statistically nonsignificant 25% increase in prostate cancer risk for the 4th (median = 659 mg/d) versus 1st (median = 211 mg/d) quartiles of calcium intake after adjustment for potential confounders. The association became considerably stronger and achieved statistical significance (hazard ratio, 2.03; 95% confidence interval, 1.23-3.34; P for trend = 0.01) for men with a below median body mass index (22.9 kg/m(2)). Dietary calcium might be a risk factor for prostate cancer even at relatively low intake.

Authors+Show Affiliations

Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523-1681, USA. Lesley.Butler@colostate.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20516117

Citation

Butler, Lesley M., et al. "Calcium Intake Increases Risk of Prostate Cancer Among Singapore Chinese." Cancer Research, vol. 70, no. 12, 2010, pp. 4941-8.
Butler LM, Wong AS, Koh WP, et al. Calcium intake increases risk of prostate cancer among Singapore Chinese. Cancer Res. 2010;70(12):4941-8.
Butler, L. M., Wong, A. S., Koh, W. P., Wang, R., Yuan, J. M., & Yu, M. C. (2010). Calcium intake increases risk of prostate cancer among Singapore Chinese. Cancer Research, 70(12), 4941-8. https://doi.org/10.1158/0008-5472.CAN-09-4544
Butler LM, et al. Calcium Intake Increases Risk of Prostate Cancer Among Singapore Chinese. Cancer Res. 2010 Jun 15;70(12):4941-8. PubMed PMID: 20516117.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Calcium intake increases risk of prostate cancer among Singapore Chinese. AU - Butler,Lesley M, AU - Wong,Alvin S, AU - Koh,Woon-Puay, AU - Wang,Renwei, AU - Yuan,Jian-Min, AU - Yu,Mimi C, Y1 - 2010/06/01/ PY - 2010/6/3/entrez PY - 2010/6/3/pubmed PY - 2010/7/23/medline SP - 4941 EP - 8 JF - Cancer research JO - Cancer Res VL - 70 IS - 12 N2 - Consumption of dairy products, the primary source of calcium in Western diets, has been found to be positively associated with prostate cancer. In an Asian diet, nondairy foods are the major contributors of calcium. Thus, a study of dietary calcium and prostate cancer in Asians can better inform on whether calcium, as opposed to other dairy components, is responsible for the dairy foods-prostate cancer association. We examined calcium intake and prostate cancer risk among 27,293 men in the Singapore Chinese Health Study that was established between 1993 and 1998. As of December 31, 2007, 298 incident prostate cancer cases had been diagnosed among the cohort members. Diet was assessed at baseline with a validated 165-item food-frequency questionnaire. It is hypothesized that there is greater net absorption of calcium in smaller individuals. Therefore, the calcium-prostate cancer association was also assessed in stratified analyses by median body mass index. Vegetables were the largest contributor of daily calcium intake in the study population. Overall, we observed a modest, statistically nonsignificant 25% increase in prostate cancer risk for the 4th (median = 659 mg/d) versus 1st (median = 211 mg/d) quartiles of calcium intake after adjustment for potential confounders. The association became considerably stronger and achieved statistical significance (hazard ratio, 2.03; 95% confidence interval, 1.23-3.34; P for trend = 0.01) for men with a below median body mass index (22.9 kg/m(2)). Dietary calcium might be a risk factor for prostate cancer even at relatively low intake. SN - 1538-7445 UR - https://www.unboundmedicine.com/medline/citation/20516117/Calcium_intake_increases_risk_of_prostate_cancer_among_Singapore_Chinese_ L2 - http://cancerres.aacrjournals.org/cgi/pmidlookup?view=long&pmid=20516117 DB - PRIME DP - Unbound Medicine ER -