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Carbon nanotube composites for glucose biosensor incorporated with reverse iontophoresis function for noninvasive glucose monitoring.
Int J Nanomedicine. 2010 May 13; 5:343-9.IJ

Abstract

This study aims to develop an amperometric glucose biosensor, based on carbon nanotubes material for reverse iontophoresis, fabricated by immobilizing a mixture of glucose oxidase (GOD) and multiwalled carbon nanotubes (MWCNT) epoxy-composite, on a planar screen-printed carbon electrode. MWCNT was employed to ensure proper incorporation into the epoxy mixture and faster electron transfer between the GOD and the transducer. Results showed this biosensor possesses a low detection potential (+500 mV), good sensitivity (4 microA/mM) and an excellent linear response range (r(2) = 0.999; 0-4 mM) of glucose detection at +500 mV (versus Ag/AgCl). The response time of the biosensor was about 25 s. In addition, the biosensor could be used in conjunction with reverse iontophoresis technique. In an actual evaluation model, an excellent linear relationship (r(2) = 0.986) was found between the glucose concentration of the actual model and the biosensor's current response. Thus, a glucose biosensor based on carbon nanotube composites and incorporated with reverse iontophoresis function was developed.

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Authors+Show Affiliations

Sun TP
Department of Electrical Engineering, Graduate Institute of Biomedicine and Biomedical Technology, National Chi Nan University, Nantou,Taiwan, ROC.
Shieh HL
No affiliation info available
Ching CT
No affiliation info available
Yao YD
No affiliation info available
Huang SH
No affiliation info available
Liu CM
No affiliation info available
Liu WH
No affiliation info available
Chen CY
No affiliation info available

MeSH

Biosensing TechniquesElectrodesEquipment DesignEquipment Failure AnalysisGlucoseIontophoresisNanotechnologyNanotubes, Carbon

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20517479

Citation

Sun, Tai-Ping, et al. "Carbon Nanotube Composites for Glucose Biosensor Incorporated With Reverse Iontophoresis Function for Noninvasive Glucose Monitoring." International Journal of Nanomedicine, vol. 5, 2010, pp. 343-9.
Sun TP, Shieh HL, Ching CT, et al. Carbon nanotube composites for glucose biosensor incorporated with reverse iontophoresis function for noninvasive glucose monitoring. Int J Nanomedicine. 2010;5:343-9.
Sun, T. P., Shieh, H. L., Ching, C. T., Yao, Y. D., Huang, S. H., Liu, C. M., Liu, W. H., & Chen, C. Y. (2010). Carbon nanotube composites for glucose biosensor incorporated with reverse iontophoresis function for noninvasive glucose monitoring. International Journal of Nanomedicine, 5, 343-9.
Sun TP, et al. Carbon Nanotube Composites for Glucose Biosensor Incorporated With Reverse Iontophoresis Function for Noninvasive Glucose Monitoring. Int J Nanomedicine. 2010 May 13;5:343-9. PubMed PMID: 20517479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Carbon nanotube composites for glucose biosensor incorporated with reverse iontophoresis function for noninvasive glucose monitoring. AU - Sun,Tai-Ping, AU - Shieh,Hsiu-Li, AU - Ching,Congo Tak-Shing, AU - Yao,Yan-Dong, AU - Huang,Su-Hua, AU - Liu,Chia-Ming, AU - Liu,Wei-Hao, AU - Chen,Chung-Yuan, Y1 - 2010/05/13/ PY - 2010/6/3/entrez PY - 2010/6/3/pubmed PY - 2010/9/14/medline KW - amperometric KW - biosensors KW - carbon nanotubes KW - glucose monitoring KW - reverse iontophoresis SP - 343 EP - 9 JF - International journal of nanomedicine JO - Int J Nanomedicine VL - 5 N2 - This study aims to develop an amperometric glucose biosensor, based on carbon nanotubes material for reverse iontophoresis, fabricated by immobilizing a mixture of glucose oxidase (GOD) and multiwalled carbon nanotubes (MWCNT) epoxy-composite, on a planar screen-printed carbon electrode. MWCNT was employed to ensure proper incorporation into the epoxy mixture and faster electron transfer between the GOD and the transducer. Results showed this biosensor possesses a low detection potential (+500 mV), good sensitivity (4 microA/mM) and an excellent linear response range (r(2) = 0.999; 0-4 mM) of glucose detection at +500 mV (versus Ag/AgCl). The response time of the biosensor was about 25 s. In addition, the biosensor could be used in conjunction with reverse iontophoresis technique. In an actual evaluation model, an excellent linear relationship (r(2) = 0.986) was found between the glucose concentration of the actual model and the biosensor's current response. Thus, a glucose biosensor based on carbon nanotube composites and incorporated with reverse iontophoresis function was developed. SN - 1178-2013 UR - https://www.unboundmedicine.com/medline/citation/20517479/Carbon_nanotube_composites_for_glucose_biosensor_incorporated_with_reverse_iontophoresis_function_for_noninvasive_glucose_monitoring_ L2 - https://www.dovepress.com/articles.php?article_id=4359 DB - PRIME DP - Unbound Medicine ER -