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The role of allergy in the etiology of Reinke's edema on vocal folds.
Wien Klin Wochenschr. 2010 May; 122 Suppl 2:44-8.WK

Abstract

AIM

To identify the role of allergy in the occurrence of Reinke's edema on vocal folds.

METHODS

This was a prospective study in patients with Reinke's edema on vocal folds (n = 80) and a control group of patients without Reinke's edema (n = 80). All the patients were examined by the same ENT specialist at an ENT outpatient center in the period 2001-2003. The control group comprised 80 successive patients from the same clinic who were willing to cooperate in the study and were not already being treated for allergic disease by any specialist other than an ENT specialist. Patients from both groups were examined by rigid laryngoscope, skin prick allergic testing (type I allergy) and laboratory determination of serum thyroid-stimulating hormone level.

RESULTS

The prevalence of allergy was not significantly different between the two groups: 20.0% in the patients with Reinke's edema and 23.8% in the control group (P = 0.576). No significant difference was detected in the prevalence of allergy when comparing patients with recurrent Reinke's edema after previous surgical treatment (n = 10) with patients with a first occurrence (n = 70) (P = 1.000). However, we found significantly more type I allergy in the patients with Reinke's edema and chronic hyperplastic rhinitis than in the patients with Reinke's edema without chronic hyperplastic rhinitis. All other risk factors (reflux of gastric content to the larynx, vocal abuse or misuse, unfavorable microclimate conditions at work, thyroid diseases) appeared significantly more often in the group with Reinke's edema on vocal folds than in the control group.

CONCLUSIONS

Type I allergy is not a crucial factor in the pathogenesis of Reinke's edema on vocal folds or in recurrence of the disease after surgical treatment.

Authors+Show Affiliations

Department of Otorhinolaryngology and Cervicofacial Surgery, Maribor Teaching Hospital, Maribor, Slovenia. alenka.kravos@sb-mb.siNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20517671

Citation

Kravos, Alenka, et al. "The Role of Allergy in the Etiology of Reinke's Edema On Vocal Folds." Wiener Klinische Wochenschrift, vol. 122 Suppl 2, 2010, pp. 44-8.
Kravos A, Zupevc A, Cizmarevic B, et al. The role of allergy in the etiology of Reinke's edema on vocal folds. Wien Klin Wochenschr. 2010;122 Suppl 2:44-8.
Kravos, A., Zupevc, A., Cizmarevic, B., & Hocevar-Boltezar, I. (2010). The role of allergy in the etiology of Reinke's edema on vocal folds. Wiener Klinische Wochenschrift, 122 Suppl 2, 44-8. https://doi.org/10.1007/s00508-010-1349-6
Kravos A, et al. The Role of Allergy in the Etiology of Reinke's Edema On Vocal Folds. Wien Klin Wochenschr. 2010;122 Suppl 2:44-8. PubMed PMID: 20517671.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of allergy in the etiology of Reinke's edema on vocal folds. AU - Kravos,Alenka, AU - Zupevc,Avgust, AU - Cizmarevic,Bogdan, AU - Hocevar-Boltezar,Irena, PY - 2010/6/3/entrez PY - 2010/6/11/pubmed PY - 2010/10/23/medline SP - 44 EP - 8 JF - Wiener klinische Wochenschrift JO - Wien. Klin. Wochenschr. VL - 122 Suppl 2 N2 - AIM: To identify the role of allergy in the occurrence of Reinke's edema on vocal folds. METHODS: This was a prospective study in patients with Reinke's edema on vocal folds (n = 80) and a control group of patients without Reinke's edema (n = 80). All the patients were examined by the same ENT specialist at an ENT outpatient center in the period 2001-2003. The control group comprised 80 successive patients from the same clinic who were willing to cooperate in the study and were not already being treated for allergic disease by any specialist other than an ENT specialist. Patients from both groups were examined by rigid laryngoscope, skin prick allergic testing (type I allergy) and laboratory determination of serum thyroid-stimulating hormone level. RESULTS: The prevalence of allergy was not significantly different between the two groups: 20.0% in the patients with Reinke's edema and 23.8% in the control group (P = 0.576). No significant difference was detected in the prevalence of allergy when comparing patients with recurrent Reinke's edema after previous surgical treatment (n = 10) with patients with a first occurrence (n = 70) (P = 1.000). However, we found significantly more type I allergy in the patients with Reinke's edema and chronic hyperplastic rhinitis than in the patients with Reinke's edema without chronic hyperplastic rhinitis. All other risk factors (reflux of gastric content to the larynx, vocal abuse or misuse, unfavorable microclimate conditions at work, thyroid diseases) appeared significantly more often in the group with Reinke's edema on vocal folds than in the control group. CONCLUSIONS: Type I allergy is not a crucial factor in the pathogenesis of Reinke's edema on vocal folds or in recurrence of the disease after surgical treatment. SN - 1613-7671 UR - https://www.unboundmedicine.com/medline/citation/20517671/The_role_of_allergy_in_the_etiology_of_Reinke's_edema_on_vocal_folds_ L2 - https://dx.doi.org/10.1007/s00508-010-1349-6 DB - PRIME DP - Unbound Medicine ER -