Tags

Type your tag names separated by a space and hit enter

Effect of trans fatty acids on plasma lipids, platelet function and systolic blood pressure in stroke-prone spontaneously hypertensive rats.
Lipids. 1991 Jan; 26(1):46-52.L

Abstract

To investigate the effect of trans fatty acids on plasma lipid levels and systolic blood pressure, hydrogenated corn oil was fed to SHRSP (stroke-prone spontaneously hypertensive rats) and WKY (Wistar-Kyoto) rats for 30 days. Significantly lower systolic blood pressure and plasma total cholesterol were observed in SHRSP rats fed trans fatty acids when compared with rats fed cis fatty acids from olive oil. In addition, higher HDL cholesterol and lower VLDL plus chylomicron cholesterol levels were found in SHRSP rats fed trans fatty acids. Although no significant changes of systolic blood pressure and plasma total cholesterol levels were observed in WKY rats after trans fatty acids treatment, WKY rats fed trans fatty acids had lower plasma LDL cholesterol and higher HDL cholesterol levels. In addition, platelet aggregation induced by collagen was decreased in WKY rats fed trans fatty acids. It is interesting that trans fatty acids increased the activity of plasma lecithin:cholesterol acyltransferase (LCAT) in both SHRSP and WKY rats. The observed influence of trans fatty acids on plasma lipid levels, systolic blood pressure and platelet aggregation suggests that trans fatty acids might prevent thrombotic disorders in SHRSP rats.

Authors+Show Affiliations

Department of Food Chemistry, Faculty of Agriculture, Tohoku University, Sendai, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2051884

Citation

Chiang, M T., et al. "Effect of Trans Fatty Acids On Plasma Lipids, Platelet Function and Systolic Blood Pressure in Stroke-prone Spontaneously Hypertensive Rats." Lipids, vol. 26, no. 1, 1991, pp. 46-52.
Chiang MT, Otomo MI, Itoh H, et al. Effect of trans fatty acids on plasma lipids, platelet function and systolic blood pressure in stroke-prone spontaneously hypertensive rats. Lipids. 1991;26(1):46-52.
Chiang, M. T., Otomo, M. I., Itoh, H., Furukawa, Y., Kimura, S., & Fujimoto, H. (1991). Effect of trans fatty acids on plasma lipids, platelet function and systolic blood pressure in stroke-prone spontaneously hypertensive rats. Lipids, 26(1), 46-52.
Chiang MT, et al. Effect of Trans Fatty Acids On Plasma Lipids, Platelet Function and Systolic Blood Pressure in Stroke-prone Spontaneously Hypertensive Rats. Lipids. 1991;26(1):46-52. PubMed PMID: 2051884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of trans fatty acids on plasma lipids, platelet function and systolic blood pressure in stroke-prone spontaneously hypertensive rats. AU - Chiang,M T, AU - Otomo,M I, AU - Itoh,H, AU - Furukawa,Y, AU - Kimura,S, AU - Fujimoto,H, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 46 EP - 52 JF - Lipids JO - Lipids VL - 26 IS - 1 N2 - To investigate the effect of trans fatty acids on plasma lipid levels and systolic blood pressure, hydrogenated corn oil was fed to SHRSP (stroke-prone spontaneously hypertensive rats) and WKY (Wistar-Kyoto) rats for 30 days. Significantly lower systolic blood pressure and plasma total cholesterol were observed in SHRSP rats fed trans fatty acids when compared with rats fed cis fatty acids from olive oil. In addition, higher HDL cholesterol and lower VLDL plus chylomicron cholesterol levels were found in SHRSP rats fed trans fatty acids. Although no significant changes of systolic blood pressure and plasma total cholesterol levels were observed in WKY rats after trans fatty acids treatment, WKY rats fed trans fatty acids had lower plasma LDL cholesterol and higher HDL cholesterol levels. In addition, platelet aggregation induced by collagen was decreased in WKY rats fed trans fatty acids. It is interesting that trans fatty acids increased the activity of plasma lecithin:cholesterol acyltransferase (LCAT) in both SHRSP and WKY rats. The observed influence of trans fatty acids on plasma lipid levels, systolic blood pressure and platelet aggregation suggests that trans fatty acids might prevent thrombotic disorders in SHRSP rats. SN - 0024-4201 UR - https://www.unboundmedicine.com/medline/citation/2051884/Effect_of_trans_fatty_acids_on_plasma_lipids_platelet_function_and_systolic_blood_pressure_in_stroke_prone_spontaneously_hypertensive_rats_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0024-4201&date=1991&volume=26&issue=1&spage=46 DB - PRIME DP - Unbound Medicine ER -