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The usefulness and challenges of transgenic mouse models in the study of Alzheimer's disease.
CNS Neurol Disord Drug Targets 2010; 9(4):386-94CN

Abstract

Alzheimer's disease is a progressive, neurodegenerative disorder characterized by a devastating cognitive decline. The disease is identified pathologically by amyloid plaques composed of aggregated amyloid- peptide, neurofibrillary tangles composed of aggregated, hyperphosphorylated tau protein and neuron loss. While the disease was first described in 1906, transgenic mouse models for the study of Alzheimer's disease pathologies have only been available to scientists for fifteen years. Despite the generation of many different mouse models that develop amyloid plaques or neurofibrillary tangles, it has only been in recent years that mouse models demonstrating the two pathologies together have been made. Also, neuron loss has been difficult to achieve in many models. Most recently, several transgenic mouse lines have been generated that do demonstrate all three pathological characteristics of Alzheimer's disease: amyloid plaques, neurofibrillary tangles and neuron loss. This review will focus on the advances made in our understanding of Alzheimer's disease pathology using the transgenic mouse models. It will also discuss the limitations associated with studying some of these mice and how transgenic mouse models have contributed to the development of therapeutics for the treatment of Alzheimer's disease.

Authors+Show Affiliations

Duke University Medical Center, Department of Medicine, Durham, NC 27710, USA. donna.wilcock@gmail.com

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20522016

Citation

Wilcock, Donna M.. "The Usefulness and Challenges of Transgenic Mouse Models in the Study of Alzheimer's Disease." CNS & Neurological Disorders Drug Targets, vol. 9, no. 4, 2010, pp. 386-94.
Wilcock DM. The usefulness and challenges of transgenic mouse models in the study of Alzheimer's disease. CNS Neurol Disord Drug Targets. 2010;9(4):386-94.
Wilcock, D. M. (2010). The usefulness and challenges of transgenic mouse models in the study of Alzheimer's disease. CNS & Neurological Disorders Drug Targets, 9(4), pp. 386-94.
Wilcock DM. The Usefulness and Challenges of Transgenic Mouse Models in the Study of Alzheimer's Disease. CNS Neurol Disord Drug Targets. 2010;9(4):386-94. PubMed PMID: 20522016.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The usefulness and challenges of transgenic mouse models in the study of Alzheimer's disease. A1 - Wilcock,Donna M, PY - 2010/03/31/received PY - 2010/04/04/accepted PY - 2010/6/5/entrez PY - 2010/6/5/pubmed PY - 2010/11/10/medline SP - 386 EP - 94 JF - CNS & neurological disorders drug targets JO - CNS Neurol Disord Drug Targets VL - 9 IS - 4 N2 - Alzheimer's disease is a progressive, neurodegenerative disorder characterized by a devastating cognitive decline. The disease is identified pathologically by amyloid plaques composed of aggregated amyloid- peptide, neurofibrillary tangles composed of aggregated, hyperphosphorylated tau protein and neuron loss. While the disease was first described in 1906, transgenic mouse models for the study of Alzheimer's disease pathologies have only been available to scientists for fifteen years. Despite the generation of many different mouse models that develop amyloid plaques or neurofibrillary tangles, it has only been in recent years that mouse models demonstrating the two pathologies together have been made. Also, neuron loss has been difficult to achieve in many models. Most recently, several transgenic mouse lines have been generated that do demonstrate all three pathological characteristics of Alzheimer's disease: amyloid plaques, neurofibrillary tangles and neuron loss. This review will focus on the advances made in our understanding of Alzheimer's disease pathology using the transgenic mouse models. It will also discuss the limitations associated with studying some of these mice and how transgenic mouse models have contributed to the development of therapeutics for the treatment of Alzheimer's disease. SN - 1996-3181 UR - https://www.unboundmedicine.com/medline/citation/20522016/The_usefulness_and_challenges_of_transgenic_mouse_models_in_the_study_of_Alzheimer's_disease_ L2 - http://www.eurekaselect.com/93966/article DB - PRIME DP - Unbound Medicine ER -