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Synthesis and microbial studies of (4-oxo-thiazolidinyl) sulfonamides bearing quinazolin-4(3H)ones.
Acta Pol Pharm. 2010 May-Jun; 67(3):267-75.AP

Abstract

2-[(2,6-Dichlorophenyl)amino]phenylacetic acid (A) on reaction with thionyl chloride gave corresponding acid chloride (B). A series of (4-oxo-thiazolidinyl)sulfonamides of quinazolin-4(3H)ones (4a-l) were prepared from Schiff bases (3a-l) of 2-[2-(2,6-dichlorophenyl)amino]phenylmethyl-3-[(4-aminophenyl)sulfonamido-1-yl]quinazolin-4(3H)one (D) and substituted aromatic aldehyde. Newly synthesized compounds have been examined on the basis of elemental analysis, IR, 1H NMR and 13C NMR spectra. Antibacterial activity (minimum inhibitory concentration - MIC) against Gram-positive (S. aureus & S. pyogeneus) and Gram-negative (P. aeruginosa and E. coli) bacteria, as well as antifungal acivities (MIC) against C. albicans, A. niger and A. clavatus were determined by broth dilution method. Some of the compounds were endowed with a remarkable antibacterial as well as antifungal acivities.

Authors+Show Affiliations

Department of Chemistry, Veer Narmad South Gujarat University, Surat-395 007, India. drnavin@satyam.net.inNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20524429

Citation

Patel, Navin B., et al. "Synthesis and Microbial Studies of (4-oxo-thiazolidinyl) Sulfonamides Bearing Quinazolin-4(3H)ones." Acta Poloniae Pharmaceutica, vol. 67, no. 3, 2010, pp. 267-75.
Patel NB, Patel VN, Patel HR, et al. Synthesis and microbial studies of (4-oxo-thiazolidinyl) sulfonamides bearing quinazolin-4(3H)ones. Acta Pol Pharm. 2010;67(3):267-75.
Patel, N. B., Patel, V. N., Patel, H. R., Shaikh, F. M., & Patel, J. C. (2010). Synthesis and microbial studies of (4-oxo-thiazolidinyl) sulfonamides bearing quinazolin-4(3H)ones. Acta Poloniae Pharmaceutica, 67(3), 267-75.
Patel NB, et al. Synthesis and Microbial Studies of (4-oxo-thiazolidinyl) Sulfonamides Bearing Quinazolin-4(3H)ones. Acta Pol Pharm. 2010 May-Jun;67(3):267-75. PubMed PMID: 20524429.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and microbial studies of (4-oxo-thiazolidinyl) sulfonamides bearing quinazolin-4(3H)ones. AU - Patel,Navin B, AU - Patel,Virendra N, AU - Patel,Hemant R, AU - Shaikh,Faiyaz M, AU - Patel,Jaymin C, PY - 2010/6/8/entrez PY - 2010/6/9/pubmed PY - 2010/6/25/medline SP - 267 EP - 75 JF - Acta poloniae pharmaceutica JO - Acta Pol Pharm VL - 67 IS - 3 N2 - 2-[(2,6-Dichlorophenyl)amino]phenylacetic acid (A) on reaction with thionyl chloride gave corresponding acid chloride (B). A series of (4-oxo-thiazolidinyl)sulfonamides of quinazolin-4(3H)ones (4a-l) were prepared from Schiff bases (3a-l) of 2-[2-(2,6-dichlorophenyl)amino]phenylmethyl-3-[(4-aminophenyl)sulfonamido-1-yl]quinazolin-4(3H)one (D) and substituted aromatic aldehyde. Newly synthesized compounds have been examined on the basis of elemental analysis, IR, 1H NMR and 13C NMR spectra. Antibacterial activity (minimum inhibitory concentration - MIC) against Gram-positive (S. aureus & S. pyogeneus) and Gram-negative (P. aeruginosa and E. coli) bacteria, as well as antifungal acivities (MIC) against C. albicans, A. niger and A. clavatus were determined by broth dilution method. Some of the compounds were endowed with a remarkable antibacterial as well as antifungal acivities. SN - 0001-6837 UR - https://www.unboundmedicine.com/medline/citation/20524429/Synthesis_and_microbial_studies_of__4_oxo_thiazolidinyl__sulfonamides_bearing_quinazolin_4_3H_ones_ L2 - http://www.ptfarm.pl/pub/File/Acta_Poloniae/2010/3/267.pdf DB - PRIME DP - Unbound Medicine ER -