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[Bone marrow transplantation in congenital defects of immunity].
Pediatr Med Chir. 1991 Jan-Feb; 13(1):27-30.PM

Abstract

BMT can cure several congenital immunological defects: if in these disease the engrafting is easier, the GVH reactions are more frequent and severe. The possibility to deplete from T lymphocyte the marrow before infusion, has overcame this difficulty. From 1968 183 BMT have been performed in Europe on patients with SCID (70 from HLA-identical donor, 113 from HLA-nonidentical donor). The survival after 2 years is 76% in the first group, and 56% in the second group (100 marrows have been T-depleted with different techniques). Strict isolation procedures before the transplant are very important to achieve good results. The possibility to treat different immunodeficiency With BMT are also discussed.

Authors+Show Affiliations

Clinica Pediatrica, Ospedale Civile, Brescia, Italia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

ita

PubMed ID

2052452

Citation

Porta, F, et al. "[Bone Marrow Transplantation in Congenital Defects of Immunity]." La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics, vol. 13, no. 1, 1991, pp. 27-30.
Porta F, Notarangelo LD, Candotti F, et al. [Bone marrow transplantation in congenital defects of immunity]. Pediatr Med Chir. 1991;13(1):27-30.
Porta, F., Notarangelo, L. D., Candotti, F., Mazzolari, E., Lanfranchi, A., & Ugazio, A. G. (1991). [Bone marrow transplantation in congenital defects of immunity]. La Pediatria Medica E Chirurgica : Medical and Surgical Pediatrics, 13(1), 27-30.
Porta F, et al. [Bone Marrow Transplantation in Congenital Defects of Immunity]. Pediatr Med Chir. 1991 Jan-Feb;13(1):27-30. PubMed PMID: 2052452.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Bone marrow transplantation in congenital defects of immunity]. AU - Porta,F, AU - Notarangelo,L D, AU - Candotti,F, AU - Mazzolari,E, AU - Lanfranchi,A, AU - Ugazio,A G, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 27 EP - 30 JF - La Pediatria medica e chirurgica : Medical and surgical pediatrics JO - Pediatr Med Chir VL - 13 IS - 1 N2 - BMT can cure several congenital immunological defects: if in these disease the engrafting is easier, the GVH reactions are more frequent and severe. The possibility to deplete from T lymphocyte the marrow before infusion, has overcame this difficulty. From 1968 183 BMT have been performed in Europe on patients with SCID (70 from HLA-identical donor, 113 from HLA-nonidentical donor). The survival after 2 years is 76% in the first group, and 56% in the second group (100 marrows have been T-depleted with different techniques). Strict isolation procedures before the transplant are very important to achieve good results. The possibility to treat different immunodeficiency With BMT are also discussed. SN - 0391-5387 UR - https://www.unboundmedicine.com/medline/citation/2052452/[Bone_marrow_transplantation_in_congenital_defects_of_immunity]_ L2 - http://www.diseaseinfosearch.org/result/7171 DB - PRIME DP - Unbound Medicine ER -