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Evaluation of status of trace and toxic metals in biological samples (scalp hair, blood, and urine) of normal and anemic children of two age groups.
Biol Trace Elem Res 2011; 141(1-3):131-49BT

Abstract

Anemia affects a substantial portion of the world's population, provoking severe health problems as well as important economic losses to the region in which this condition is found. This study was designed to compare the levels of essential trace and toxic elements in scalp hair, blood, and urine samples of anemic children (n = 132) with age range 1-5 and 6-10 years of both genders. For a comparative study, 134 non-anemic age- and sex-matched children as control subjects, residing in the same city, were selected. The metals in the biological samples were measured by flame atomic absorption spectrophotometry/electrothermal atomic absorption spectrometry prior to microwave-assisted acid digestion. The proposed method was validated using certified reference samples of hair, blood, and urine. The results indicated significantly lower levels of iron, copper, and zinc in the biological samples as compared to the control children of both genders (p = 0.01-0.008). The mean values of lead and cadmium were significantly high in all three biological samples of anemic children as compared to non-anemic children of both age groups (p = 0.005-0.001). The ratios of essential metal to toxic metals in the biological samples of anemic children of both age groups were significantly lower than that of controls. Deficiency of essential trace metals and high level of toxic metals may play a role in the development of anemia in the subjects under study.

Authors+Show Affiliations

National Center of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan. shah_ceac@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20526751

Citation

Shah, Faheem, et al. "Evaluation of Status of Trace and Toxic Metals in Biological Samples (scalp Hair, Blood, and Urine) of Normal and Anemic Children of Two Age Groups." Biological Trace Element Research, vol. 141, no. 1-3, 2011, pp. 131-49.
Shah F, Kazi TG, Afridi HI, et al. Evaluation of status of trace and toxic metals in biological samples (scalp hair, blood, and urine) of normal and anemic children of two age groups. Biol Trace Elem Res. 2011;141(1-3):131-49.
Shah, F., Kazi, T. G., Afridi, H. I., Kazi, N., Baig, J. A., Shah, A. Q., ... Wadhwa, S. K. (2011). Evaluation of status of trace and toxic metals in biological samples (scalp hair, blood, and urine) of normal and anemic children of two age groups. Biological Trace Element Research, 141(1-3), pp. 131-49. doi:10.1007/s12011-010-8736-8.
Shah F, et al. Evaluation of Status of Trace and Toxic Metals in Biological Samples (scalp Hair, Blood, and Urine) of Normal and Anemic Children of Two Age Groups. Biol Trace Elem Res. 2011;141(1-3):131-49. PubMed PMID: 20526751.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of status of trace and toxic metals in biological samples (scalp hair, blood, and urine) of normal and anemic children of two age groups. AU - Shah,Faheem, AU - Kazi,Tasneem Gul, AU - Afridi,Hassan Imran, AU - Kazi,Naveed, AU - Baig,Jameel Ahmed, AU - Shah,Abdul Qadir, AU - Khan,Sumaira, AU - Kolachi,Nida Fatima, AU - Wadhwa,Sham Kumar, Y1 - 2010/06/05/ PY - 2010/04/15/received PY - 2010/05/14/accepted PY - 2010/6/8/entrez PY - 2010/6/8/pubmed PY - 2011/9/16/medline SP - 131 EP - 49 JF - Biological trace element research JO - Biol Trace Elem Res VL - 141 IS - 1-3 N2 - Anemia affects a substantial portion of the world's population, provoking severe health problems as well as important economic losses to the region in which this condition is found. This study was designed to compare the levels of essential trace and toxic elements in scalp hair, blood, and urine samples of anemic children (n = 132) with age range 1-5 and 6-10 years of both genders. For a comparative study, 134 non-anemic age- and sex-matched children as control subjects, residing in the same city, were selected. The metals in the biological samples were measured by flame atomic absorption spectrophotometry/electrothermal atomic absorption spectrometry prior to microwave-assisted acid digestion. The proposed method was validated using certified reference samples of hair, blood, and urine. The results indicated significantly lower levels of iron, copper, and zinc in the biological samples as compared to the control children of both genders (p = 0.01-0.008). The mean values of lead and cadmium were significantly high in all three biological samples of anemic children as compared to non-anemic children of both age groups (p = 0.005-0.001). The ratios of essential metal to toxic metals in the biological samples of anemic children of both age groups were significantly lower than that of controls. Deficiency of essential trace metals and high level of toxic metals may play a role in the development of anemia in the subjects under study. SN - 1559-0720 UR - https://www.unboundmedicine.com/medline/citation/20526751/Evaluation_of_status_of_trace_and_toxic_metals_in_biological_samples__scalp_hair_blood_and_urine__of_normal_and_anemic_children_of_two_age_groups_ L2 - https://dx.doi.org/10.1007/s12011-010-8736-8 DB - PRIME DP - Unbound Medicine ER -