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The effect of soy-derived isoflavones over hot flushes, menopausal symptoms and mood in climacteric women with increased body mass index.
Gynecol Endocrinol. 2011 May; 27(5):307-13.GE

Abstract

BACKGROUND

Risk-benefit issues raised after the WHI have significantly increased the use of alternative treatments for the menopause. Despite this, data regarding the effect of soy isoflavones over mood and menopausal symptoms in high risk populations is still lacking.

OBJECTIVE

To evaluate the effect of soy derived isoflavones over hot flushes, menopausal symptoms and mood in climacteric women with increased body mass index (BMI).

METHODS

Fifty symptomatic climacteric women aged 40 to 59 with increased BMI (≥ 25) were recruited to receive oral 100 mg/day of soy derived isoflavones (Climasoy) for 3 months. Hot flushes (frequency/intensity), menopausal symptoms (Menopause Rating Scale [MRS]) and mood (Hamilton Depressive Rating Scale [HDRS]) were evaluated at baseline and at 90 days.

RESULTS

A total of 45 women completed the study. After 3 months of soy isoflavone supplementation hot flushes significantly decreased in percentage, number and severity (100% to 31.1%; 3.9 ± 2.3 to 0.4 ± 0.8 and 2.6 ± 0.9 to 0.4 ± 0.8, respectively, p < 0.001). MRS scores (total and for subscales) reflecting general menopausal symptoms also significantly decreased compared to baseline. Regarding mood, after three months total HDRS scores and the rate of women presenting depressed mood (scores ≥ 8) significantly decreased (16.3 ± 5.4 to 6.9 ± 5.2 and 93.3% to 28.9%, respectively, p < 0.05). There was no effect on blood pressure levels or BMI values after treatment.

CONCLUSION

In this high risk climacteric population, soy derived isoflavone treatment improved mood as well as vasomotor and general menopausal symptoms. More research is required to determine if the positive effect over mood is a direct or an indirect one through hot flush alleviation.

Authors+Show Affiliations

Instituto para La Salud de La Mujer, Guayaquil, Ecuador. institutochedraui@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

20528204

Citation

Chedraui, Peter, et al. "The Effect of Soy-derived Isoflavones Over Hot Flushes, Menopausal Symptoms and Mood in Climacteric Women With Increased Body Mass Index." Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, vol. 27, no. 5, 2011, pp. 307-13.
Chedraui P, San Miguel G, Schwager G. The effect of soy-derived isoflavones over hot flushes, menopausal symptoms and mood in climacteric women with increased body mass index. Gynecol Endocrinol. 2011;27(5):307-13.
Chedraui, P., San Miguel, G., & Schwager, G. (2011). The effect of soy-derived isoflavones over hot flushes, menopausal symptoms and mood in climacteric women with increased body mass index. Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 27(5), 307-13. https://doi.org/10.3109/09513590.2010.490614
Chedraui P, San Miguel G, Schwager G. The Effect of Soy-derived Isoflavones Over Hot Flushes, Menopausal Symptoms and Mood in Climacteric Women With Increased Body Mass Index. Gynecol Endocrinol. 2011;27(5):307-13. PubMed PMID: 20528204.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of soy-derived isoflavones over hot flushes, menopausal symptoms and mood in climacteric women with increased body mass index. AU - Chedraui,Peter, AU - San Miguel,Glenda, AU - Schwager,Gino, Y1 - 2010/06/08/ PY - 2010/6/10/entrez PY - 2010/6/10/pubmed PY - 2011/8/4/medline SP - 307 EP - 13 JF - Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology JO - Gynecol. Endocrinol. VL - 27 IS - 5 N2 - BACKGROUND: Risk-benefit issues raised after the WHI have significantly increased the use of alternative treatments for the menopause. Despite this, data regarding the effect of soy isoflavones over mood and menopausal symptoms in high risk populations is still lacking. OBJECTIVE: To evaluate the effect of soy derived isoflavones over hot flushes, menopausal symptoms and mood in climacteric women with increased body mass index (BMI). METHODS: Fifty symptomatic climacteric women aged 40 to 59 with increased BMI (≥ 25) were recruited to receive oral 100 mg/day of soy derived isoflavones (Climasoy) for 3 months. Hot flushes (frequency/intensity), menopausal symptoms (Menopause Rating Scale [MRS]) and mood (Hamilton Depressive Rating Scale [HDRS]) were evaluated at baseline and at 90 days. RESULTS: A total of 45 women completed the study. After 3 months of soy isoflavone supplementation hot flushes significantly decreased in percentage, number and severity (100% to 31.1%; 3.9 ± 2.3 to 0.4 ± 0.8 and 2.6 ± 0.9 to 0.4 ± 0.8, respectively, p < 0.001). MRS scores (total and for subscales) reflecting general menopausal symptoms also significantly decreased compared to baseline. Regarding mood, after three months total HDRS scores and the rate of women presenting depressed mood (scores ≥ 8) significantly decreased (16.3 ± 5.4 to 6.9 ± 5.2 and 93.3% to 28.9%, respectively, p < 0.05). There was no effect on blood pressure levels or BMI values after treatment. CONCLUSION: In this high risk climacteric population, soy derived isoflavone treatment improved mood as well as vasomotor and general menopausal symptoms. More research is required to determine if the positive effect over mood is a direct or an indirect one through hot flush alleviation. SN - 1473-0766 UR - https://www.unboundmedicine.com/medline/citation/20528204/The_effect_of_soy_derived_isoflavones_over_hot_flushes_menopausal_symptoms_and_mood_in_climacteric_women_with_increased_body_mass_index_ L2 - http://www.tandfonline.com/doi/full/10.3109/09513590.2010.490614 DB - PRIME DP - Unbound Medicine ER -