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Levels and dynamic changes of serum fibroblast growth factor 23 in hypophosphatemic rickets/osteomalacia.
Chin Med J (Engl). 2010 May 05; 123(9):1158-62.CM

Abstract

BACKGROUND

Hypophosphatemic rickets/osteomalacia is a group of diseases characterised by defective mineralization of bone due to hypophosphatemia and low 1,25-dihydroxy vitamin D. To explore the role of fibroblast growth factor 23 (FGF-23) in the regulation of phosphate homeostasis, we measured the circulating concentrations of this growth factor in healthy individuals and in patients with hypophosphatemic rickets/osteomalacia.

METHODS

Nineteen patients with hypophosphatemic rickets/osteomalacia were included in hypophosphatemic group (HP, 12 female and 7 male, mean age was 30 years), and 19 healthy age-matched individuals served as the control group. Full length FGF-23 fragments were measured by two-site enzyme-linked immunosorbent assay.

RESULTS

Mean FGF-23 concentrations were significantly higher in the HP group ((87.4 +/- 43.6) pg/ml) compared with the control group ((19.2 +/- 6.16) pg/ml; P < 0.001). In 1 patient with tumour-induced osteomalacia, serum FGF-23 concentrations were 84.1 pg/ml; these concentrations were normalized 2 hours after a hemangiopericytoma resection (7.8 pg/ml). Subsequently, serum 1,25(OH)(2) vitamin D3 concentrations significantly increased from 21.3 pg/ml to 89.3 pg/ml, and serum phosphorus levels were normalized.

CONCLUSIONS

Serum FGF-23 concentrations were markedly elevated in patients with hypophosphatemic rickets. FGF-23 plays an important role in the pathogenesis of hypophosphatemic rickets/osteomalacia.

Authors+Show Affiliations

Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. xiaweibo@medmail.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20529556

Citation

Xia, Wei-bo, et al. "Levels and Dynamic Changes of Serum Fibroblast Growth Factor 23 in Hypophosphatemic Rickets/osteomalacia." Chinese Medical Journal, vol. 123, no. 9, 2010, pp. 1158-62.
Xia WB, Jiang Y, Li M, et al. Levels and dynamic changes of serum fibroblast growth factor 23 in hypophosphatemic rickets/osteomalacia. Chin Med J (Engl). 2010;123(9):1158-62.
Xia, W. B., Jiang, Y., Li, M., Xing, X. P., Wang, O., Hu, Y. Y., Zhang, H. B., Liu, H. C., Meng, X. W., & Zhou, X. Y. (2010). Levels and dynamic changes of serum fibroblast growth factor 23 in hypophosphatemic rickets/osteomalacia. Chinese Medical Journal, 123(9), 1158-62.
Xia WB, et al. Levels and Dynamic Changes of Serum Fibroblast Growth Factor 23 in Hypophosphatemic Rickets/osteomalacia. Chin Med J (Engl). 2010 May 5;123(9):1158-62. PubMed PMID: 20529556.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Levels and dynamic changes of serum fibroblast growth factor 23 in hypophosphatemic rickets/osteomalacia. AU - Xia,Wei-bo, AU - Jiang,Yan, AU - Li,Mei, AU - Xing,Xiao-ping, AU - Wang,Ou, AU - Hu,Ying-ying, AU - Zhang,Hua-bing, AU - Liu,Huai-cheng, AU - Meng,Xun-wu, AU - Zhou,Xue-ying, PY - 2010/6/10/entrez PY - 2010/6/10/pubmed PY - 2010/9/15/medline SP - 1158 EP - 62 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 123 IS - 9 N2 - BACKGROUND: Hypophosphatemic rickets/osteomalacia is a group of diseases characterised by defective mineralization of bone due to hypophosphatemia and low 1,25-dihydroxy vitamin D. To explore the role of fibroblast growth factor 23 (FGF-23) in the regulation of phosphate homeostasis, we measured the circulating concentrations of this growth factor in healthy individuals and in patients with hypophosphatemic rickets/osteomalacia. METHODS: Nineteen patients with hypophosphatemic rickets/osteomalacia were included in hypophosphatemic group (HP, 12 female and 7 male, mean age was 30 years), and 19 healthy age-matched individuals served as the control group. Full length FGF-23 fragments were measured by two-site enzyme-linked immunosorbent assay. RESULTS: Mean FGF-23 concentrations were significantly higher in the HP group ((87.4 +/- 43.6) pg/ml) compared with the control group ((19.2 +/- 6.16) pg/ml; P < 0.001). In 1 patient with tumour-induced osteomalacia, serum FGF-23 concentrations were 84.1 pg/ml; these concentrations were normalized 2 hours after a hemangiopericytoma resection (7.8 pg/ml). Subsequently, serum 1,25(OH)(2) vitamin D3 concentrations significantly increased from 21.3 pg/ml to 89.3 pg/ml, and serum phosphorus levels were normalized. CONCLUSIONS: Serum FGF-23 concentrations were markedly elevated in patients with hypophosphatemic rickets. FGF-23 plays an important role in the pathogenesis of hypophosphatemic rickets/osteomalacia. SN - 2542-5641 UR - https://www.unboundmedicine.com/medline/citation/20529556/Levels_and_dynamic_changes_of_serum_fibroblast_growth_factor_23_in_hypophosphatemic_rickets/osteomalacia_ L2 - https://Insights.ovid.com/pubmed?pmid=20529556 DB - PRIME DP - Unbound Medicine ER -