Tags

Type your tag names separated by a space and hit enter

Serum vitamin B(12) concentrations among mothers and newborns and follow-up study to assess implication on the growth velocity and the urinary methylmalonic acid excretion.
Int J Vitam Nutr Res. 2009 Sep; 79(5-6):297-307.IJ

Abstract

OBJECTIVE

Cobalamin (B(12)) deficiency has been reported in infants born to mothers with low cobalamin intake. Early diagnosis of vitamin B(12) deficiency in infants is critical for the prevention of neurobehavioral disorders. We investigated the relationship between serum vitamin B(12) level in newborns and in their healthy mothers who consumed an omnivorous diet. Anthropometry was studied longitudinally to assess the growth velocity of the infants. Urinary methylmalonic acid (MMA) excretion of 6-month old infants was compared retrospectively as the biomarker correlated with the initial serum vitamin B(12) concentrations.

METHODS

Serum cobalamin and blood hemoglobin were determined in 84 pairs of newborns and their mothers. Urinary MMA excretion was measured in the same subjects during the first 6 months of the post partum period.

RESULTS

At birth, median serum cobalamin levels were 152.0 pmol/L in the mothers and 296.6 pmol/L in the newborns. Maternal and neonatal serum cobalamin levels had no effect on growth velocity during the first six months of postnatal life. Serum maternal and neonatal cobalamin levels were inversely associated with urinary MMA excretion.

CONCLUSION

Early diagnosis of vitamin B(12) status in neonates and infants is crucial, particularly in nutritionally deprived areas. Biochemical measurement of plasma cobalamin or its metabolic marker MMA is highly recommended. Urinary MMA measurement in cobalamin diagnostics provides an advantage in that blood sampling is not required. A vitamin B(12) taskforce should be created to alleviate vitamin deficiency and its negative consequences.

Links

Publisher Full Text

Authors+Show Affiliations

Hussein L
Department of Nutrition-National Research Center, Giza, Egypt. egcairouw38@yahoo.com
Abdel Aziz S
No affiliation info available
Tapouzada S
No affiliation info available
Boehles H
No affiliation info available

MeSH

AdolescentAdultBirth WeightBody WeightChild DevelopmentFemaleHumansInfant, NewbornLinear ModelsLongitudinal StudiesMaleMethylmalonic AcidMothersPregnancyRetrospective StudiesVitamin B 12Vitamin B 12 DeficiencyYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20533216

Citation

Hussein, Laila, et al. "Serum Vitamin B(12) Concentrations Among Mothers and Newborns and Follow-up Study to Assess Implication On the Growth Velocity and the Urinary Methylmalonic Acid Excretion." International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition, vol. 79, no. 5-6, 2009, pp. 297-307.
Hussein L, Abdel Aziz S, Tapouzada S, et al. Serum vitamin B(12) concentrations among mothers and newborns and follow-up study to assess implication on the growth velocity and the urinary methylmalonic acid excretion. Int J Vitam Nutr Res. 2009;79(5-6):297-307.
Hussein, L., Abdel Aziz, S., Tapouzada, S., & Boehles, H. (2009). Serum vitamin B(12) concentrations among mothers and newborns and follow-up study to assess implication on the growth velocity and the urinary methylmalonic acid excretion. International Journal for Vitamin and Nutrition Research. Internationale Zeitschrift Fur Vitamin- Und Ernahrungsforschung. Journal International De Vitaminologie Et De Nutrition, 79(5-6), 297-307. https://doi.org/10.1024/0300-9831.79.56.297
Hussein L, et al. Serum Vitamin B(12) Concentrations Among Mothers and Newborns and Follow-up Study to Assess Implication On the Growth Velocity and the Urinary Methylmalonic Acid Excretion. Int J Vitam Nutr Res. 2009;79(5-6):297-307. PubMed PMID: 20533216.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum vitamin B(12) concentrations among mothers and newborns and follow-up study to assess implication on the growth velocity and the urinary methylmalonic acid excretion. AU - Hussein,Laila, AU - Abdel Aziz,Sahar, AU - Tapouzada,Salwa, AU - Boehles,H, PY - 2010/6/10/entrez PY - 2010/6/10/pubmed PY - 2010/7/21/medline SP - 297 EP - 307 JF - International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition JO - Int J Vitam Nutr Res VL - 79 IS - 5-6 N2 - OBJECTIVE: Cobalamin (B(12)) deficiency has been reported in infants born to mothers with low cobalamin intake. Early diagnosis of vitamin B(12) deficiency in infants is critical for the prevention of neurobehavioral disorders. We investigated the relationship between serum vitamin B(12) level in newborns and in their healthy mothers who consumed an omnivorous diet. Anthropometry was studied longitudinally to assess the growth velocity of the infants. Urinary methylmalonic acid (MMA) excretion of 6-month old infants was compared retrospectively as the biomarker correlated with the initial serum vitamin B(12) concentrations. METHODS: Serum cobalamin and blood hemoglobin were determined in 84 pairs of newborns and their mothers. Urinary MMA excretion was measured in the same subjects during the first 6 months of the post partum period. RESULTS: At birth, median serum cobalamin levels were 152.0 pmol/L in the mothers and 296.6 pmol/L in the newborns. Maternal and neonatal serum cobalamin levels had no effect on growth velocity during the first six months of postnatal life. Serum maternal and neonatal cobalamin levels were inversely associated with urinary MMA excretion. CONCLUSION: Early diagnosis of vitamin B(12) status in neonates and infants is crucial, particularly in nutritionally deprived areas. Biochemical measurement of plasma cobalamin or its metabolic marker MMA is highly recommended. Urinary MMA measurement in cobalamin diagnostics provides an advantage in that blood sampling is not required. A vitamin B(12) taskforce should be created to alleviate vitamin deficiency and its negative consequences. SN - 0300-9831 UR - https://www.unboundmedicine.com/medline/citation/20533216/Serum_vitamin_B_12__concentrations_among_mothers_and_newborns_and_follow_up_study_to_assess_implication_on_the_growth_velocity_and_the_urinary_methylmalonic_acid_excretion_ L2 - https://econtent.hogrefe.com/doi/10.1024/0300-9831.79.56.297?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -