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Risk of endometrial cancer for women diagnosed with HNPCC-related colorectal carcinoma.
Int J Cancer. 2010 Dec 01; 127(11):2678-84.IJ

Abstract

The risk of endometrial cancer (EC) subsequent to a diagnosis of colorectal cancer in women with a germline mutation in a mismatch repair gene [Lynch syndrome or hereditary non-polyposis colon cancer (HNPCC)] is unknown. We estimated the risk of EC following a diagnosis of colorectal carcinoma (CRC) for women with Lynch syndrome. A retrospective cohort study was performed on women diagnosed with CRC with a germline mutation in a mismatch repair (MMR) gene (Lynch syndrome cases), and women with microsatellite stable (MSS) CRC who were not known to carry a germline mutation (non-Lynch cases), identified from the Colon Cancer Family Registry. The incidence of EC following CRC was estimated and compared for women with and without Lynch syndrome, using adjusted hazards ratios calculated for time at risk among each group. A total of 112 women with Lynch syndrome and a previous diagnosis of CRC were compared with 908 women without Lynch and with a MSS CRC diagnosis. The estimated 10-year cumulative risk of EC subsequent to CRC was 23.4% [95% confidence interval (CI): 15-36%] for Lynch syndrome women compared with 1.6% (95% CI: 0.7-3.8%) for non-Lynch women. After adjusting for ascertainment, age at diagnosis and diagnosis of other cancers, risk of subsequent diagnosis with EC was elevated sixfold in women with Lynch syndrome compared with non-Lynch women (HR 6.2; 95% CI 2.2-17.3; p = 0.001). Approximately one quarter of women diagnosed with Lynch syndrome-associated CRC developed EC within 10 years. This supports the sentinel cancer concept and suggests that active and early management is important for these women.

Authors+Show Affiliations

School of Medicine, The University of Queensland and the Royal Brisbane and Women's Hospital, Herston, QLD, Australia. andreas_obermair@health.qld.gov.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20533284

Citation

Obermair, Andreas, et al. "Risk of Endometrial Cancer for Women Diagnosed With HNPCC-related Colorectal Carcinoma." International Journal of Cancer, vol. 127, no. 11, 2010, pp. 2678-84.
Obermair A, Youlden DR, Young JP, et al. Risk of endometrial cancer for women diagnosed with HNPCC-related colorectal carcinoma. Int J Cancer. 2010;127(11):2678-84.
Obermair, A., Youlden, D. R., Young, J. P., Lindor, N. M., Baron, J. A., Newcomb, P., Parry, S., Hopper, J. L., Haile, R., & Jenkins, M. A. (2010). Risk of endometrial cancer for women diagnosed with HNPCC-related colorectal carcinoma. International Journal of Cancer, 127(11), 2678-84. https://doi.org/10.1002/ijc.25501
Obermair A, et al. Risk of Endometrial Cancer for Women Diagnosed With HNPCC-related Colorectal Carcinoma. Int J Cancer. 2010 Dec 1;127(11):2678-84. PubMed PMID: 20533284.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of endometrial cancer for women diagnosed with HNPCC-related colorectal carcinoma. AU - Obermair,Andreas, AU - Youlden,Danny R, AU - Young,Joanne P, AU - Lindor,Noralane M, AU - Baron,John A, AU - Newcomb,Polly, AU - Parry,Susan, AU - Hopper,John L, AU - Haile,Robert, AU - Jenkins,Mark A, PY - 2010/6/10/entrez PY - 2010/6/10/pubmed PY - 2010/11/5/medline SP - 2678 EP - 84 JF - International journal of cancer JO - Int. J. Cancer VL - 127 IS - 11 N2 - The risk of endometrial cancer (EC) subsequent to a diagnosis of colorectal cancer in women with a germline mutation in a mismatch repair gene [Lynch syndrome or hereditary non-polyposis colon cancer (HNPCC)] is unknown. We estimated the risk of EC following a diagnosis of colorectal carcinoma (CRC) for women with Lynch syndrome. A retrospective cohort study was performed on women diagnosed with CRC with a germline mutation in a mismatch repair (MMR) gene (Lynch syndrome cases), and women with microsatellite stable (MSS) CRC who were not known to carry a germline mutation (non-Lynch cases), identified from the Colon Cancer Family Registry. The incidence of EC following CRC was estimated and compared for women with and without Lynch syndrome, using adjusted hazards ratios calculated for time at risk among each group. A total of 112 women with Lynch syndrome and a previous diagnosis of CRC were compared with 908 women without Lynch and with a MSS CRC diagnosis. The estimated 10-year cumulative risk of EC subsequent to CRC was 23.4% [95% confidence interval (CI): 15-36%] for Lynch syndrome women compared with 1.6% (95% CI: 0.7-3.8%) for non-Lynch women. After adjusting for ascertainment, age at diagnosis and diagnosis of other cancers, risk of subsequent diagnosis with EC was elevated sixfold in women with Lynch syndrome compared with non-Lynch women (HR 6.2; 95% CI 2.2-17.3; p = 0.001). Approximately one quarter of women diagnosed with Lynch syndrome-associated CRC developed EC within 10 years. This supports the sentinel cancer concept and suggests that active and early management is important for these women. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/20533284/Risk_of_endometrial_cancer_for_women_diagnosed_with_HNPCC_related_colorectal_carcinoma_ L2 - https://doi.org/10.1002/ijc.25501 DB - PRIME DP - Unbound Medicine ER -