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Consumption of omega-3 fatty acids and fish and risk of age-related hearing loss.
Am J Clin Nutr 2010; 92(2):416-21AJ

Abstract

BACKGROUND

Identification of modifiable risk factors that could prevent or slow the development of age-related hearing loss (presbycusis) would be valuable. Dietary polyunsaturated fatty acid (PUFA) intake may be related to age-related hearing loss.

OBJECTIVE

We aimed to determine the association between dietary intakes of omega-3 (n-3) PUFAs and fish and the risk of presbycusis.

DESIGN

The Blue Mountains Hearing Study is a population-based survey of age-related hearing loss (1997-1999 to 2002-2004). We collected dietary data by using a semiquantitative food-frequency questionnaire and calculated PUFA and fish intakes. In 2956 participants (aged > or =50 y), we measured presbycusis, which we defined as the pure-tone average of frequencies 0.5, 1.0, 2.0, and 4.0 kHz >25 decibels of hearing loss.

RESULTS

There was an inverse association between total n-3 PUFA intake and prevalent hearing loss [odds ratio (OR) per SD increase in energy-adjusted n-3 PUFAs: 0.89; 95% CI: 0.81, 0.99]. There was an inverse association between long-chain n-3 PUFAs and incident hearing loss (OR per SD increase in long-chain n-3 PUFAs: 0.76; 95% CI: 0.60, 0.97). Participants who had > or =2 servings of fish/wk compared with participants who had <1 serving of fish/wk had a significantly reduced risk (42%) of developing presbycusis at follow-up (multivariate-adjusted OR: 0.58; 95% CI: 0.35, 0.95). There was an association between consumption of > or =1 to <2 servings/wk of fish and a reduced risk of a progression of hearing loss (OR: 0.53; 95% CI: 0.32, 0.88).

CONCLUSIONS

There was an inverse association between higher intakes of long-chain n-3 PUFAs and regular weekly consumption of fish and hearing loss. Dietary intervention with n-3 PUFAs could prevent or delay the development of age-related hearing loss.

Authors+Show Affiliations

Centre for Vision Research, Department of Ophthalmology, and Westmead Millennium Institute, University of Sydney, Sydney, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20534742

Citation

Gopinath, Bamini, et al. "Consumption of Omega-3 Fatty Acids and Fish and Risk of Age-related Hearing Loss." The American Journal of Clinical Nutrition, vol. 92, no. 2, 2010, pp. 416-21.
Gopinath B, Flood VM, Rochtchina E, et al. Consumption of omega-3 fatty acids and fish and risk of age-related hearing loss. Am J Clin Nutr. 2010;92(2):416-21.
Gopinath, B., Flood, V. M., Rochtchina, E., McMahon, C. M., & Mitchell, P. (2010). Consumption of omega-3 fatty acids and fish and risk of age-related hearing loss. The American Journal of Clinical Nutrition, 92(2), pp. 416-21. doi:10.3945/ajcn.2010.29370.
Gopinath B, et al. Consumption of Omega-3 Fatty Acids and Fish and Risk of Age-related Hearing Loss. Am J Clin Nutr. 2010;92(2):416-21. PubMed PMID: 20534742.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Consumption of omega-3 fatty acids and fish and risk of age-related hearing loss. AU - Gopinath,Bamini, AU - Flood,Victoria M, AU - Rochtchina,Elena, AU - McMahon,Catherine M, AU - Mitchell,Paul, Y1 - 2010/06/09/ PY - 2010/6/11/entrez PY - 2010/6/11/pubmed PY - 2010/8/13/medline SP - 416 EP - 21 JF - The American journal of clinical nutrition JO - Am. J. Clin. Nutr. VL - 92 IS - 2 N2 - BACKGROUND: Identification of modifiable risk factors that could prevent or slow the development of age-related hearing loss (presbycusis) would be valuable. Dietary polyunsaturated fatty acid (PUFA) intake may be related to age-related hearing loss. OBJECTIVE: We aimed to determine the association between dietary intakes of omega-3 (n-3) PUFAs and fish and the risk of presbycusis. DESIGN: The Blue Mountains Hearing Study is a population-based survey of age-related hearing loss (1997-1999 to 2002-2004). We collected dietary data by using a semiquantitative food-frequency questionnaire and calculated PUFA and fish intakes. In 2956 participants (aged > or =50 y), we measured presbycusis, which we defined as the pure-tone average of frequencies 0.5, 1.0, 2.0, and 4.0 kHz >25 decibels of hearing loss. RESULTS: There was an inverse association between total n-3 PUFA intake and prevalent hearing loss [odds ratio (OR) per SD increase in energy-adjusted n-3 PUFAs: 0.89; 95% CI: 0.81, 0.99]. There was an inverse association between long-chain n-3 PUFAs and incident hearing loss (OR per SD increase in long-chain n-3 PUFAs: 0.76; 95% CI: 0.60, 0.97). Participants who had > or =2 servings of fish/wk compared with participants who had <1 serving of fish/wk had a significantly reduced risk (42%) of developing presbycusis at follow-up (multivariate-adjusted OR: 0.58; 95% CI: 0.35, 0.95). There was an association between consumption of > or =1 to <2 servings/wk of fish and a reduced risk of a progression of hearing loss (OR: 0.53; 95% CI: 0.32, 0.88). CONCLUSIONS: There was an inverse association between higher intakes of long-chain n-3 PUFAs and regular weekly consumption of fish and hearing loss. Dietary intervention with n-3 PUFAs could prevent or delay the development of age-related hearing loss. SN - 1938-3207 UR - https://www.unboundmedicine.com/medline/citation/20534742/Consumption_of_omega_3_fatty_acids_and_fish_and_risk_of_age_related_hearing_loss_ L2 - https://academic.oup.com/ajcn/article-lookup/doi/10.3945/ajcn.2010.29370 DB - PRIME DP - Unbound Medicine ER -