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[Successful selection of chemotherapy based on cell surface antigens in a patient with mixed phenotype acute leukemia].
Rinsho Ketsueki. 2010 May; 51(5):339-44.RK

Abstract

A 47-year-old man was admitted to our hospital in June 2009 because of fatigue and blast cells in peripheral blood. Bone marrow examination showed that 67% leukemic cells were positive for myeloperoxidase (MPO) and negative for esterase stain. Flow cytometric analysis (FCM) revealed the expressions of CD2, cyCD3, CD5, TdT, CD13 on the blasts. Chromosome analysis of the bone marrow cells demonstrated 46, XY in 18 of the 20 analyzed cells, 46,XY,t(1;11)(q21;p15) in 1 of the 20 analyzed cells, and 47,XY,+11 in 1 of the 20 analyzed cells. The patient was diagnosed as having mixed phenotype acute leukemia, T/myeloid, NOS, according to the WHO classification. He received induction chemotherapy for ALL, but could not achieve complete remission (CR). After initial treatment, residual leukemic cells with CD13, CD33 and MPO were detected by FCM; therefore, he received re-induction chemotherapy for AML, and achieved CR. Acute leukemia of ambiguous lineage is a relatively rare subtype in acute leukemia and standard chemotherapy has not been established. It was suggested that the selection of chemotherapy based on the results of FCM was successful in our patient.

Authors+Show Affiliations

Department of Hematology, Kanagawa Cancer Center.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

jpn

PubMed ID

20534955

Citation

Takasaki, Hitotaka, et al. "[Successful Selection of Chemotherapy Based On Cell Surface Antigens in a Patient With Mixed Phenotype Acute Leukemia]." [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, vol. 51, no. 5, 2010, pp. 339-44.
Takasaki H, Tachibana T, Tanaka M, et al. [Successful selection of chemotherapy based on cell surface antigens in a patient with mixed phenotype acute leukemia]. Rinsho Ketsueki. 2010;51(5):339-44.
Takasaki, H., Tachibana, T., Tanaka, M., Maruta, A., Ishigatsubo, Y., & Kanamoari, H. (2010). [Successful selection of chemotherapy based on cell surface antigens in a patient with mixed phenotype acute leukemia]. [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, 51(5), 339-44.
Takasaki H, et al. [Successful Selection of Chemotherapy Based On Cell Surface Antigens in a Patient With Mixed Phenotype Acute Leukemia]. Rinsho Ketsueki. 2010;51(5):339-44. PubMed PMID: 20534955.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Successful selection of chemotherapy based on cell surface antigens in a patient with mixed phenotype acute leukemia]. AU - Takasaki,Hitotaka, AU - Tachibana,Takayoshi, AU - Tanaka,Masatsugu, AU - Maruta,Atsuo, AU - Ishigatsubo,Yoshiaki, AU - Kanamoari,Heiwa, PY - 2010/6/11/entrez PY - 2010/6/11/pubmed PY - 2010/8/4/medline SP - 339 EP - 44 JF - [Rinsho ketsueki] The Japanese journal of clinical hematology JO - Rinsho Ketsueki VL - 51 IS - 5 N2 - A 47-year-old man was admitted to our hospital in June 2009 because of fatigue and blast cells in peripheral blood. Bone marrow examination showed that 67% leukemic cells were positive for myeloperoxidase (MPO) and negative for esterase stain. Flow cytometric analysis (FCM) revealed the expressions of CD2, cyCD3, CD5, TdT, CD13 on the blasts. Chromosome analysis of the bone marrow cells demonstrated 46, XY in 18 of the 20 analyzed cells, 46,XY,t(1;11)(q21;p15) in 1 of the 20 analyzed cells, and 47,XY,+11 in 1 of the 20 analyzed cells. The patient was diagnosed as having mixed phenotype acute leukemia, T/myeloid, NOS, according to the WHO classification. He received induction chemotherapy for ALL, but could not achieve complete remission (CR). After initial treatment, residual leukemic cells with CD13, CD33 and MPO were detected by FCM; therefore, he received re-induction chemotherapy for AML, and achieved CR. Acute leukemia of ambiguous lineage is a relatively rare subtype in acute leukemia and standard chemotherapy has not been established. It was suggested that the selection of chemotherapy based on the results of FCM was successful in our patient. SN - 0485-1439 UR - https://www.unboundmedicine.com/medline/citation/20534955/[Successful_selection_of_chemotherapy_based_on_cell_surface_antigens_in_a_patient_with_mixed_phenotype_acute_leukemia]_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/rinketsu/51.339?lang=en&from=PubMed DB - PRIME DP - Unbound Medicine ER -