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Telmisartan, an angiotensin-II receptor blocker ameliorates cardiac remodeling in rats with dilated cardiomyopathy.
Hypertens Res. 2010 Jul; 33(7):695-702.HR

Abstract

Multiple trials over the past several years have examined indications for angiotensin receptor blockers (ARBs) in the treatment of left ventricular (LV) dysfunction, both acutely after myocardial infarction and in chronic heart failure (CHF). However, the effects of telmisartan, an ARB in rats with CHF after experimental autoimmune myocarditis (EAM) have not yet been analyzed. CHF was elicited in Lewis rats by immunization with cardiac myosin, and 28 days after immunization, the surviving Lewis rats were divided into two groups and treated with either telmisartan (10 mg kg(-1) day(-1)) or vehicle. After 4 weeks of treatment, we analyzed the effects of telmisartan on cardiac function, proinflammatory cytokines and cardiac remodeling in EAM rats. Myocardial functional parameters measured by hemodynamic and echocardiographic studies were significantly improved by telmisartan treatment in rats with CHF compared with those of vehicle-treated rats with CHF. Telmisartan significantly reduced levels of cardiac fibrosis, hypertrophy and its marker molecules (LV mRNA expressions of transforming growth factor beta 1, collagen I and III, and atrial natriuretic peptide), and peroxisome proliferator-activated receptor--gamma protein expression compared with those of vehicle-treated rats. CHF-induced increases in myocardial mRNA expressions of proinflammatory cytokines, (interleukin (IL)-6, IL-1beta), monocyte chemoattractant protein-1 and matrix metalloproteinases (MMP-2 and -9) were also suppressed by the treatment with telmisartan. Moreover, the plasma level of angiotensin-II was significantly elevated in telmisartan-treated rats. Our results indicate that telmisartan treatment significantly improved LV function and ameliorated the progression of cardiac remodeling in rats with CHF after EAM.

Authors+Show Affiliations

Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, Niigata, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20535115

Citation

Sukumaran, Vijayakumar, et al. "Telmisartan, an angiotensin-II Receptor Blocker Ameliorates Cardiac Remodeling in Rats With Dilated Cardiomyopathy." Hypertension Research : Official Journal of the Japanese Society of Hypertension, vol. 33, no. 7, 2010, pp. 695-702.
Sukumaran V, Watanabe K, Veeraveedu PT, et al. Telmisartan, an angiotensin-II receptor blocker ameliorates cardiac remodeling in rats with dilated cardiomyopathy. Hypertens Res. 2010;33(7):695-702.
Sukumaran, V., Watanabe, K., Veeraveedu, P. T., Thandavarayan, R. A., Gurusamy, N., Ma, M., Yamaguchi, K., Suzuki, K., Kodama, M., & Aizawa, Y. (2010). Telmisartan, an angiotensin-II receptor blocker ameliorates cardiac remodeling in rats with dilated cardiomyopathy. Hypertension Research : Official Journal of the Japanese Society of Hypertension, 33(7), 695-702. https://doi.org/10.1038/hr.2010.67
Sukumaran V, et al. Telmisartan, an angiotensin-II Receptor Blocker Ameliorates Cardiac Remodeling in Rats With Dilated Cardiomyopathy. Hypertens Res. 2010;33(7):695-702. PubMed PMID: 20535115.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Telmisartan, an angiotensin-II receptor blocker ameliorates cardiac remodeling in rats with dilated cardiomyopathy. AU - Sukumaran,Vijayakumar, AU - Watanabe,Kenichi, AU - Veeraveedu,Punniyakoti T, AU - Thandavarayan,Rajarajan A, AU - Gurusamy,Narasimman, AU - Ma,Meilei, AU - Yamaguchi,Ken'ichi, AU - Suzuki,Kenji, AU - Kodama,Makoto, AU - Aizawa,Yoshifusa, Y1 - 2010/06/10/ PY - 2010/6/11/entrez PY - 2010/6/11/pubmed PY - 2010/10/22/medline SP - 695 EP - 702 JF - Hypertension research : official journal of the Japanese Society of Hypertension JO - Hypertens Res VL - 33 IS - 7 N2 - Multiple trials over the past several years have examined indications for angiotensin receptor blockers (ARBs) in the treatment of left ventricular (LV) dysfunction, both acutely after myocardial infarction and in chronic heart failure (CHF). However, the effects of telmisartan, an ARB in rats with CHF after experimental autoimmune myocarditis (EAM) have not yet been analyzed. CHF was elicited in Lewis rats by immunization with cardiac myosin, and 28 days after immunization, the surviving Lewis rats were divided into two groups and treated with either telmisartan (10 mg kg(-1) day(-1)) or vehicle. After 4 weeks of treatment, we analyzed the effects of telmisartan on cardiac function, proinflammatory cytokines and cardiac remodeling in EAM rats. Myocardial functional parameters measured by hemodynamic and echocardiographic studies were significantly improved by telmisartan treatment in rats with CHF compared with those of vehicle-treated rats with CHF. Telmisartan significantly reduced levels of cardiac fibrosis, hypertrophy and its marker molecules (LV mRNA expressions of transforming growth factor beta 1, collagen I and III, and atrial natriuretic peptide), and peroxisome proliferator-activated receptor--gamma protein expression compared with those of vehicle-treated rats. CHF-induced increases in myocardial mRNA expressions of proinflammatory cytokines, (interleukin (IL)-6, IL-1beta), monocyte chemoattractant protein-1 and matrix metalloproteinases (MMP-2 and -9) were also suppressed by the treatment with telmisartan. Moreover, the plasma level of angiotensin-II was significantly elevated in telmisartan-treated rats. Our results indicate that telmisartan treatment significantly improved LV function and ameliorated the progression of cardiac remodeling in rats with CHF after EAM. SN - 1348-4214 UR - https://www.unboundmedicine.com/medline/citation/20535115/Telmisartan_an_angiotensin_II_receptor_blocker_ameliorates_cardiac_remodeling_in_rats_with_dilated_cardiomyopathy_ DB - PRIME DP - Unbound Medicine ER -