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Body size at birth and cardiovascular response to and recovery from mental stress in children.
J Hum Hypertens. 2011 Apr; 25(4):231-40.JH

Abstract

Cardiovascular (CV) response to mental stress, a predictor of CV disease risk, may be determined already in utero. However, the underlying mechanisms remain unclear, and previous studies have used adult subjects and neglected CV recovery. We investigated 147 girls and 136 boys aged 8 years who underwent the Trier Social Stress Test for children to determine whether body size at birth is associated with CV activity. Blood pressure (BP), electrocardiogram and impedance-derived indices were recorded and analyzed from continuous measurements using Vasotrac APM205A and Biopac MP150 systems. Among girls, lower birth weight was associated with lower baseline systolic BP (SBP) and diastolic BP (DBP) values (1.9 mm Hg and 1.5 mm Hg per 1 s.d. birth weight for gestational age, respectively), higher SBP and DBP response to mental stress (1.6 mm Hg and 1.1 mm Hg per 1 s.d. birth weight for gestational age, respectively), slower BP recovery and overall higher cardiac sympathetic activity. In contrast, among boys lower birth weight was associated with higher baseline levels of SBP (2.1 mm Hg per 1 s.d. birth weight for gestational age) and total peripheral resistance (TPR), overall lower cardiac sympathetic activity, lower TPR response to mental stress and a more rapid BP and cardiac sympathetic recovery. In boys, the associations with baseline levels and cardiac sympathetic activity became significant only after adjusting for current body size. These sex-specific results suggest that individual differences in childhood CV response to and recovery from mental stress may have prenatal origins. This phenomenon may be important in linking smaller body size at birth to adult CV disease.

Authors+Show Affiliations

Institute of Behavioural Sciences, University of Helsinki, Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20535142

Citation

Feldt, K, et al. "Body Size at Birth and Cardiovascular Response to and Recovery From Mental Stress in Children." Journal of Human Hypertension, vol. 25, no. 4, 2011, pp. 231-40.
Feldt K, Räikkönen K, Pyhälä R, et al. Body size at birth and cardiovascular response to and recovery from mental stress in children. J Hum Hypertens. 2011;25(4):231-40.
Feldt, K., Räikkönen, K., Pyhälä, R., Jones, A., Phillips, D. I., Eriksson, J. G., Pesonen, A. K., Heinonen, K., Järvenpää, A. L., Strandberg, T. E., & Kajantie, E. (2011). Body size at birth and cardiovascular response to and recovery from mental stress in children. Journal of Human Hypertension, 25(4), 231-40. https://doi.org/10.1038/jhh.2010.55
Feldt K, et al. Body Size at Birth and Cardiovascular Response to and Recovery From Mental Stress in Children. J Hum Hypertens. 2011;25(4):231-40. PubMed PMID: 20535142.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body size at birth and cardiovascular response to and recovery from mental stress in children. AU - Feldt,K, AU - Räikkönen,K, AU - Pyhälä,R, AU - Jones,A, AU - Phillips,D I W, AU - Eriksson,J G, AU - Pesonen,A K, AU - Heinonen,K, AU - Järvenpää,A-L, AU - Strandberg,T E, AU - Kajantie,E, Y1 - 2010/06/10/ PY - 2010/6/11/entrez PY - 2010/6/11/pubmed PY - 2011/7/8/medline SP - 231 EP - 40 JF - Journal of human hypertension JO - J Hum Hypertens VL - 25 IS - 4 N2 - Cardiovascular (CV) response to mental stress, a predictor of CV disease risk, may be determined already in utero. However, the underlying mechanisms remain unclear, and previous studies have used adult subjects and neglected CV recovery. We investigated 147 girls and 136 boys aged 8 years who underwent the Trier Social Stress Test for children to determine whether body size at birth is associated with CV activity. Blood pressure (BP), electrocardiogram and impedance-derived indices were recorded and analyzed from continuous measurements using Vasotrac APM205A and Biopac MP150 systems. Among girls, lower birth weight was associated with lower baseline systolic BP (SBP) and diastolic BP (DBP) values (1.9 mm Hg and 1.5 mm Hg per 1 s.d. birth weight for gestational age, respectively), higher SBP and DBP response to mental stress (1.6 mm Hg and 1.1 mm Hg per 1 s.d. birth weight for gestational age, respectively), slower BP recovery and overall higher cardiac sympathetic activity. In contrast, among boys lower birth weight was associated with higher baseline levels of SBP (2.1 mm Hg per 1 s.d. birth weight for gestational age) and total peripheral resistance (TPR), overall lower cardiac sympathetic activity, lower TPR response to mental stress and a more rapid BP and cardiac sympathetic recovery. In boys, the associations with baseline levels and cardiac sympathetic activity became significant only after adjusting for current body size. These sex-specific results suggest that individual differences in childhood CV response to and recovery from mental stress may have prenatal origins. This phenomenon may be important in linking smaller body size at birth to adult CV disease. SN - 1476-5527 UR - https://www.unboundmedicine.com/medline/citation/20535142/Body_size_at_birth_and_cardiovascular_response_to_and_recovery_from_mental_stress_in_children_ L2 - https://doi.org/10.1038/jhh.2010.55 DB - PRIME DP - Unbound Medicine ER -