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Can opium abuse be a risk factor for carotid stenosis in patients who are candidates for coronary artery bypass grafting?
Cardiol J. 2010; 17(3):254-8.CJ

Abstract

BACKGROUND

Over the centuries, opium has been the most frequent substance abused in the Middle East. There are many controversial aspects about the effects of opioids on the atherosclerosis process, which is still unclear.

METHODS

All patients who were candidates for coronary artery bypass graft in Tehran Heart Center were registered and evaluated for risk factors such as diabetes mellitus, hypertension, smoking status and duration, opium abuse, involved coronary arteries and left main branch lesion > 50%, carotid stenosis > or = 70%.

RESULTS

A total of 1,339 patients were enrolled in the study, of whom 400 (29.9%) were female and the other 939 (70.1%) male. Female patients were omitted from analysis due to the low numbers of female opium addicts. Our study revealed that in the addicted population, the risk of diabetes and hypertension was lower than in the non-addicted group (p < 0.05 for each variable) and fasting blood sugar tended to be less in addicted ones, but the number of involved coronary arteries, left main stenosis > 50% and extent of carotid stenosis was not significantly different between the two groups.

CONCLUSIONS

Our investigations demonstrate that opium is not cardioprotective, as has been claimed by some previous studies, and does not even decelerate atherosclerosis of carotid arteries in opium-addicted patients, but more evidence is still needed to completely prove the case.

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Authors+Show Affiliations

Shirani S
Tehran Heart Center Teheran Uniwersity of Medical Sciences, Department of Radiology, Tehran, Iran. sh_shirani@yahoo.com
Shakiba M
No affiliation info available
Soleymanzadeh M
No affiliation info available
Esfandbod M
No affiliation info available

MeSH

AgedCarotid StenosisCoronary AngiographyCoronary Artery BypassCoronary StenosisHumansIranMaleMiddle AgedOpioid-Related DisordersOpiumRisk AssessmentRisk FactorsSeverity of Illness IndexUltrasonography, Doppler

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20535715

Citation

Shirani, Shapour, et al. "Can Opium Abuse Be a Risk Factor for Carotid Stenosis in Patients Who Are Candidates for Coronary Artery Bypass Grafting?" Cardiology Journal, vol. 17, no. 3, 2010, pp. 254-8.
Shirani S, Shakiba M, Soleymanzadeh M, et al. Can opium abuse be a risk factor for carotid stenosis in patients who are candidates for coronary artery bypass grafting? Cardiol J. 2010;17(3):254-8.
Shirani, S., Shakiba, M., Soleymanzadeh, M., & Esfandbod, M. (2010). Can opium abuse be a risk factor for carotid stenosis in patients who are candidates for coronary artery bypass grafting? Cardiology Journal, 17(3), 254-8.
Shirani S, et al. Can Opium Abuse Be a Risk Factor for Carotid Stenosis in Patients Who Are Candidates for Coronary Artery Bypass Grafting. Cardiol J. 2010;17(3):254-8. PubMed PMID: 20535715.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Can opium abuse be a risk factor for carotid stenosis in patients who are candidates for coronary artery bypass grafting? AU - Shirani,Shapour, AU - Shakiba,Madjid, AU - Soleymanzadeh,Maryam, AU - Esfandbod,Maryam, PY - 2010/6/11/entrez PY - 2010/6/11/pubmed PY - 2010/9/21/medline SP - 254 EP - 8 JF - Cardiology journal JO - Cardiol J VL - 17 IS - 3 N2 - BACKGROUND: Over the centuries, opium has been the most frequent substance abused in the Middle East. There are many controversial aspects about the effects of opioids on the atherosclerosis process, which is still unclear. METHODS: All patients who were candidates for coronary artery bypass graft in Tehran Heart Center were registered and evaluated for risk factors such as diabetes mellitus, hypertension, smoking status and duration, opium abuse, involved coronary arteries and left main branch lesion > 50%, carotid stenosis > or = 70%. RESULTS: A total of 1,339 patients were enrolled in the study, of whom 400 (29.9%) were female and the other 939 (70.1%) male. Female patients were omitted from analysis due to the low numbers of female opium addicts. Our study revealed that in the addicted population, the risk of diabetes and hypertension was lower than in the non-addicted group (p < 0.05 for each variable) and fasting blood sugar tended to be less in addicted ones, but the number of involved coronary arteries, left main stenosis > 50% and extent of carotid stenosis was not significantly different between the two groups. CONCLUSIONS: Our investigations demonstrate that opium is not cardioprotective, as has been claimed by some previous studies, and does not even decelerate atherosclerosis of carotid arteries in opium-addicted patients, but more evidence is still needed to completely prove the case. SN - 1897-5593 UR - https://www.unboundmedicine.com/medline/citation/20535715/Can_opium_abuse_be_a_risk_factor_for_carotid_stenosis_in_patients_who_are_candidates_for_coronary_artery_bypass_grafting L2 - http://www.cardiologyjournal.org/en/darmowy_pdf.phtml?id=96&amp;indeks_art=1318 DB - PRIME DP - Unbound Medicine ER -