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Comparison of the skin-prick test and Phadia ImmunoCAP as tools to diagnose house-dust mite allergy.
Am J Rhinol Allergy. 2010 May-Jun; 24(3):226-9.AJ

Abstract

BACKGROUND

When the skin-prick test (SPT) and in vitro test such as ImmunoCAP assay are performed simultaneously, results do not always coincide in some patients. Our objectives, therefore, were (1) to assess differences in allergic test results according to age group and (2) to establish appropriate guidelines for diagnosing mite allergy according to age.

METHODS

A total of 692 participants complaining of allergic rhinitis symptoms participated. Patients were divided according to age; the mean age was 32 years (range, 8-76 years). The SPT and ImmunoCAP assays were performed to detect allergies to house-dust mites (Dermatophagoides pteronyssinus and Dermatophagoides farinae). The association between age and the result of each allergy test were examined, and a cutoff age for proper application of each test was than estimated.

RESULTS

Three hundred thirty-six patients (48.6%) were allergic to D. pteronyssinus and 350 patients (50.6%) were allergic to D. farinae. In the case of D. pteronyssinus, SPT was proved to be more useful in detecting allergy for subjects <50 years old (p < 0.0001). However in case of D. farinae, ImmunoCAP was useful for all age groups, but SPT showed decreased ratio of positive result for subjects >30 years old (p < 0.0001).

CONCLUSION

This study was the first to compare results of allergy tests according to age using true allergens. For patients >50 years of age, the ImmunoCAP was found to be the preferred method for detecting allergy to house-dust mites and for patients <30 years old, SPT is the recommended first choice.

Authors+Show Affiliations

Department of Otorhinolaryngology-Head and Neck Surgery, Masan Samsung Hospital, Masan, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

20537291

Citation

Jung, Yong Gi, et al. "Comparison of the Skin-prick Test and Phadia ImmunoCAP as Tools to Diagnose House-dust Mite Allergy." American Journal of Rhinology & Allergy, vol. 24, no. 3, 2010, pp. 226-9.
Jung YG, Cho HJ, Park GY, et al. Comparison of the skin-prick test and Phadia ImmunoCAP as tools to diagnose house-dust mite allergy. Am J Rhinol Allergy. 2010;24(3):226-9.
Jung, Y. G., Cho, H. J., Park, G. Y., Min, J. Y., Kim, H. Y., Dhong, H. J., Chung, S. K., & Kim, S. W. (2010). Comparison of the skin-prick test and Phadia ImmunoCAP as tools to diagnose house-dust mite allergy. American Journal of Rhinology & Allergy, 24(3), 226-9. https://doi.org/10.2500/ajra.2010.24.3459
Jung YG, et al. Comparison of the Skin-prick Test and Phadia ImmunoCAP as Tools to Diagnose House-dust Mite Allergy. Am J Rhinol Allergy. 2010;24(3):226-9. PubMed PMID: 20537291.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparison of the skin-prick test and Phadia ImmunoCAP as tools to diagnose house-dust mite allergy. AU - Jung,Yong Gi, AU - Cho,Hyun-Jin, AU - Park,Ga Young, AU - Min,Jin-Young, AU - Kim,Hyo Yeol, AU - Dhong,Hun-Jong, AU - Chung,Seung Kyu, AU - Kim,Seon Woo, PY - 2010/6/12/entrez PY - 2010/6/12/pubmed PY - 2010/11/16/medline SP - 226 EP - 9 JF - American journal of rhinology & allergy JO - Am J Rhinol Allergy VL - 24 IS - 3 N2 - BACKGROUND: When the skin-prick test (SPT) and in vitro test such as ImmunoCAP assay are performed simultaneously, results do not always coincide in some patients. Our objectives, therefore, were (1) to assess differences in allergic test results according to age group and (2) to establish appropriate guidelines for diagnosing mite allergy according to age. METHODS: A total of 692 participants complaining of allergic rhinitis symptoms participated. Patients were divided according to age; the mean age was 32 years (range, 8-76 years). The SPT and ImmunoCAP assays were performed to detect allergies to house-dust mites (Dermatophagoides pteronyssinus and Dermatophagoides farinae). The association between age and the result of each allergy test were examined, and a cutoff age for proper application of each test was than estimated. RESULTS: Three hundred thirty-six patients (48.6%) were allergic to D. pteronyssinus and 350 patients (50.6%) were allergic to D. farinae. In the case of D. pteronyssinus, SPT was proved to be more useful in detecting allergy for subjects <50 years old (p < 0.0001). However in case of D. farinae, ImmunoCAP was useful for all age groups, but SPT showed decreased ratio of positive result for subjects >30 years old (p < 0.0001). CONCLUSION: This study was the first to compare results of allergy tests according to age using true allergens. For patients >50 years of age, the ImmunoCAP was found to be the preferred method for detecting allergy to house-dust mites and for patients <30 years old, SPT is the recommended first choice. SN - 1945-8932 UR - https://www.unboundmedicine.com/medline/citation/20537291/Comparison_of_the_skin_prick_test_and_Phadia_ImmunoCAP_as_tools_to_diagnose_house_dust_mite_allergy_ L2 - http://journals.sagepub.com/doi/full/10.2500/ajra.2010.24.3459?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -