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Effect of crocetin from Gardenia jasminoides Ellis on sleep: a pilot study.
Phytomedicine 2010; 17(11):840-3P

Abstract

Crocetin is a pharmacologically active carotenoid compound of Gardenia jasminoides Ellis used as a traditional herbal medicine and natural colorant. The present pilot study investigated the effect of crocetin on sleep. The clinical trial comprised a double-blind, placebo-controlled, crossover trial of 21 healthy adult men with a mild sleep complaint. It included two intervention periods of 2 weeks each, separated by a 2-week washout period. We measured objective sleep quality using an actigraph, and assessed the subjective symptoms using St Mary's Hospital Sleep Questionnaire. Actigraph data showed that after administration of crocetin, the number of wakening episodes was reduced compared to that of the placebo (p=0.025). Subjective data from St Mary's Hospital Sleep Questionnaire showed that crocetin tended to improve the quality of sleep compared to sleep before its intake. Additionally, no side effects from crocetin intake were observed. The results suggest that crocetin may contribute to improving the quality of sleep.

Authors+Show Affiliations

Department of Health Science, Faculty of Health Science for Welfare, Kansai University of Welfare Sciences, Kashiwara, Osaka, Japan.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

20537515

Citation

Kuratsune, H, et al. "Effect of Crocetin From Gardenia Jasminoides Ellis On Sleep: a Pilot Study." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 17, no. 11, 2010, pp. 840-3.
Kuratsune H, Umigai N, Takeno R, et al. Effect of crocetin from Gardenia jasminoides Ellis on sleep: a pilot study. Phytomedicine. 2010;17(11):840-3.
Kuratsune, H., Umigai, N., Takeno, R., Kajimoto, Y., & Nakano, T. (2010). Effect of crocetin from Gardenia jasminoides Ellis on sleep: a pilot study. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 17(11), pp. 840-3. doi:10.1016/j.phymed.2010.03.025.
Kuratsune H, et al. Effect of Crocetin From Gardenia Jasminoides Ellis On Sleep: a Pilot Study. Phytomedicine. 2010;17(11):840-3. PubMed PMID: 20537515.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of crocetin from Gardenia jasminoides Ellis on sleep: a pilot study. AU - Kuratsune,H, AU - Umigai,N, AU - Takeno,R, AU - Kajimoto,Y, AU - Nakano,T, PY - 2009/10/21/received PY - 2010/02/08/revised PY - 2010/03/30/accepted PY - 2010/6/12/entrez PY - 2010/6/12/pubmed PY - 2011/3/4/medline SP - 840 EP - 3 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 17 IS - 11 N2 - Crocetin is a pharmacologically active carotenoid compound of Gardenia jasminoides Ellis used as a traditional herbal medicine and natural colorant. The present pilot study investigated the effect of crocetin on sleep. The clinical trial comprised a double-blind, placebo-controlled, crossover trial of 21 healthy adult men with a mild sleep complaint. It included two intervention periods of 2 weeks each, separated by a 2-week washout period. We measured objective sleep quality using an actigraph, and assessed the subjective symptoms using St Mary's Hospital Sleep Questionnaire. Actigraph data showed that after administration of crocetin, the number of wakening episodes was reduced compared to that of the placebo (p=0.025). Subjective data from St Mary's Hospital Sleep Questionnaire showed that crocetin tended to improve the quality of sleep compared to sleep before its intake. Additionally, no side effects from crocetin intake were observed. The results suggest that crocetin may contribute to improving the quality of sleep. SN - 1618-095X UR - https://www.unboundmedicine.com/medline/citation/20537515/full_citation/Effect_of_crocetin_from_Gardenia_Jasminoides_Ellis_on_sleep:_A_pilot_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(10)00120-0 DB - PRIME DP - Unbound Medicine ER -