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Adiponectin, resistin and leptin response to dietary intervention in diabetic nephropathy.
J Ren Nutr 2010; 20(4):255-62JR

Abstract

OBJECTIVE

Adipokines play an important role in metabolic regulations. Obesity, diabetes, and renal disturbances affect adipokine profile by influencing their complex effects on metabolism. Our objective was to assess the effect of low-energy diet intervention on serum adiponectin, leptin, and resistin levels in diabetic nephropathy.

METHODS

Seventeen subjects with diabetes type 2 and nephropathy participated in the study. After estimation of individual resting metabolic rates by indirect calorimetry, diets introducing 20% energy deficit were applied. At baseline and after 2 months of dieting, the following parameters were measured: body composition by dual x-ray spectrometry and serum adiponectin (Adp), leptin (Lep), resistin (Res), insulin, urea, creatinine, glucose, glycosylated hemoglobin, C-reactive protein, and tumor necrosis factor-alpha concentrations. Homeostatic model assessment (HOMA) was used to quantify insulin resistance.

RESULTS

Total energy, protein, and fat intakes diminished significantly with intentional dieting. Significant decreases in total body fat mass (FM) and its percentage in body mass (FM%) and trunk and gynoid fat mass, as well as in serum resistin and tumor necrosis factor-alpha levels, were also observed. Responses of adipokines to dietary treatment varied individually. Generally, they were affected by FM. Alterations in Lep concentrations correlated negatively with baseline FM, FM%, and android and gynoid fat mass and positively with changes in intake of protein, carbohydrates, and total energy of the consumed diet. Changes in Adp were inversely related to FM after therapy. Alterations in Res concentrations correlated positively with android fat mass before therapy and initial Lep levels. Adiponectin was inversely related to HOMA index before and after treatment.

CONCLUSIONS

Low-energy diet applied in diabetic nephropathy may decrease serum resistin levels and inflammation. In addition, responses of all adipokines to dieting appear to be affected by body fat mass, especially android fat mass.

Authors+Show Affiliations

Department of Dietetics, Faculty of Human Nutrition and Consumer Sciences, Warsaw University of Life Sciences, 02-776 Warsaw, Poland. lucyna_kozlowska@sggw.plNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20537918

Citation

Kozłowska, Lucyna, et al. "Adiponectin, Resistin and Leptin Response to Dietary Intervention in Diabetic Nephropathy." Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, vol. 20, no. 4, 2010, pp. 255-62.
Kozłowska L, Rydzewski A, Fiderkiewicz B, et al. Adiponectin, resistin and leptin response to dietary intervention in diabetic nephropathy. J Ren Nutr. 2010;20(4):255-62.
Kozłowska, L., Rydzewski, A., Fiderkiewicz, B., Wasińska-Krawczyk, A., Grzechnik, A., & Rosołowska-Huszcz, D. (2010). Adiponectin, resistin and leptin response to dietary intervention in diabetic nephropathy. Journal of Renal Nutrition : the Official Journal of the Council On Renal Nutrition of the National Kidney Foundation, 20(4), pp. 255-62. doi:10.1053/j.jrn.2010.01.009.
Kozłowska L, et al. Adiponectin, Resistin and Leptin Response to Dietary Intervention in Diabetic Nephropathy. J Ren Nutr. 2010;20(4):255-62. PubMed PMID: 20537918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adiponectin, resistin and leptin response to dietary intervention in diabetic nephropathy. AU - Kozłowska,Lucyna, AU - Rydzewski,Andrzej, AU - Fiderkiewicz,Bartosz, AU - Wasińska-Krawczyk,Anna, AU - Grzechnik,Agnieszka, AU - Rosołowska-Huszcz,Danuta, Y1 - 2010/05/26/ PY - 2008/10/09/received PY - 2010/6/12/entrez PY - 2010/6/12/pubmed PY - 2010/9/18/medline SP - 255 EP - 62 JF - Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation JO - J Ren Nutr VL - 20 IS - 4 N2 - OBJECTIVE: Adipokines play an important role in metabolic regulations. Obesity, diabetes, and renal disturbances affect adipokine profile by influencing their complex effects on metabolism. Our objective was to assess the effect of low-energy diet intervention on serum adiponectin, leptin, and resistin levels in diabetic nephropathy. METHODS: Seventeen subjects with diabetes type 2 and nephropathy participated in the study. After estimation of individual resting metabolic rates by indirect calorimetry, diets introducing 20% energy deficit were applied. At baseline and after 2 months of dieting, the following parameters were measured: body composition by dual x-ray spectrometry and serum adiponectin (Adp), leptin (Lep), resistin (Res), insulin, urea, creatinine, glucose, glycosylated hemoglobin, C-reactive protein, and tumor necrosis factor-alpha concentrations. Homeostatic model assessment (HOMA) was used to quantify insulin resistance. RESULTS: Total energy, protein, and fat intakes diminished significantly with intentional dieting. Significant decreases in total body fat mass (FM) and its percentage in body mass (FM%) and trunk and gynoid fat mass, as well as in serum resistin and tumor necrosis factor-alpha levels, were also observed. Responses of adipokines to dietary treatment varied individually. Generally, they were affected by FM. Alterations in Lep concentrations correlated negatively with baseline FM, FM%, and android and gynoid fat mass and positively with changes in intake of protein, carbohydrates, and total energy of the consumed diet. Changes in Adp were inversely related to FM after therapy. Alterations in Res concentrations correlated positively with android fat mass before therapy and initial Lep levels. Adiponectin was inversely related to HOMA index before and after treatment. CONCLUSIONS: Low-energy diet applied in diabetic nephropathy may decrease serum resistin levels and inflammation. In addition, responses of all adipokines to dieting appear to be affected by body fat mass, especially android fat mass. SN - 1532-8503 UR - https://www.unboundmedicine.com/medline/citation/20537918/Adiponectin_resistin_and_leptin_response_to_dietary_intervention_in_diabetic_nephropathy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1051-2276(10)00010-5 DB - PRIME DP - Unbound Medicine ER -