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Maternal obesity impairs hippocampal BDNF production and spatial learning performance in young mouse offspring.
Neurochem Int 2010; 57(3):235-47NI

Abstract

Maternal obesity may affect the child's long-term development and health, increasing the risk of diabetes and metabolic syndrome. In addition to the metabolic and endocrine systems, recent reports have indicated that maternal obesity also modulates neural circuit formation in the offspring. However, this not yet been fully investigated. Here, we examined the effect of diet-induced maternal obesity on hippocampal development and function in the mouse offspring. Adult female mice were fed either a normal diet (ND, 4% fat) or a high-fat diet (HFD, 32% fat) before mating and throughout pregnancy and lactation. After weaning, all offspring were fed with a normal diet. We found that HFD offspring showed increased lipid peroxidation in the hippocampus during early postnatal development. HFD offspring had less brain-derived neurotrophic factor (BDNF) in the hippocampus than ND offspring. BDNF has been shown to play crucial roles in neuronal differentiation, plasticity and hippocampus-dependent cognitive functions such as spatial learning and memory. Using retroviral labeling, we demonstrated that dendritic arborization of new hippocampal neurons was impaired in the young HFD offspring. Finally, we evaluated cognitive function in these offspring using hippocampus-dependent behavioral tasks. The Barnes maze test demonstrated that HFD offspring showed impaired acquisition of spatial learning in the young but not adult period. This study, using a mouse model, indicates that diet-induced maternal obesity impairs hippocampal BDNF production and spatial cognitive function in young offspring, possibly due to their metabolic and oxidative changes.

Authors+Show Affiliations

Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20538025

Citation

Tozuka, Yusuke, et al. "Maternal Obesity Impairs Hippocampal BDNF Production and Spatial Learning Performance in Young Mouse Offspring." Neurochemistry International, vol. 57, no. 3, 2010, pp. 235-47.
Tozuka Y, Kumon M, Wada E, et al. Maternal obesity impairs hippocampal BDNF production and spatial learning performance in young mouse offspring. Neurochem Int. 2010;57(3):235-47.
Tozuka, Y., Kumon, M., Wada, E., Onodera, M., Mochizuki, H., & Wada, K. (2010). Maternal obesity impairs hippocampal BDNF production and spatial learning performance in young mouse offspring. Neurochemistry International, 57(3), pp. 235-47. doi:10.1016/j.neuint.2010.05.015.
Tozuka Y, et al. Maternal Obesity Impairs Hippocampal BDNF Production and Spatial Learning Performance in Young Mouse Offspring. Neurochem Int. 2010;57(3):235-47. PubMed PMID: 20538025.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal obesity impairs hippocampal BDNF production and spatial learning performance in young mouse offspring. AU - Tozuka,Yusuke, AU - Kumon,Mami, AU - Wada,Etsuko, AU - Onodera,Masafumi, AU - Mochizuki,Hideki, AU - Wada,Keiji, Y1 - 2010/06/09/ PY - 2010/01/18/received PY - 2010/05/15/revised PY - 2010/05/31/accepted PY - 2010/6/12/entrez PY - 2010/6/12/pubmed PY - 2010/11/5/medline SP - 235 EP - 47 JF - Neurochemistry international JO - Neurochem. Int. VL - 57 IS - 3 N2 - Maternal obesity may affect the child's long-term development and health, increasing the risk of diabetes and metabolic syndrome. In addition to the metabolic and endocrine systems, recent reports have indicated that maternal obesity also modulates neural circuit formation in the offspring. However, this not yet been fully investigated. Here, we examined the effect of diet-induced maternal obesity on hippocampal development and function in the mouse offspring. Adult female mice were fed either a normal diet (ND, 4% fat) or a high-fat diet (HFD, 32% fat) before mating and throughout pregnancy and lactation. After weaning, all offspring were fed with a normal diet. We found that HFD offspring showed increased lipid peroxidation in the hippocampus during early postnatal development. HFD offspring had less brain-derived neurotrophic factor (BDNF) in the hippocampus than ND offspring. BDNF has been shown to play crucial roles in neuronal differentiation, plasticity and hippocampus-dependent cognitive functions such as spatial learning and memory. Using retroviral labeling, we demonstrated that dendritic arborization of new hippocampal neurons was impaired in the young HFD offspring. Finally, we evaluated cognitive function in these offspring using hippocampus-dependent behavioral tasks. The Barnes maze test demonstrated that HFD offspring showed impaired acquisition of spatial learning in the young but not adult period. This study, using a mouse model, indicates that diet-induced maternal obesity impairs hippocampal BDNF production and spatial cognitive function in young offspring, possibly due to their metabolic and oxidative changes. SN - 1872-9754 UR - https://www.unboundmedicine.com/medline/citation/20538025/Maternal_obesity_impairs_hippocampal_BDNF_production_and_spatial_learning_performance_in_young_mouse_offspring_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-0186(10)00184-1 DB - PRIME DP - Unbound Medicine ER -