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Apolipoprotein B-to-A1 ratio as a predictor of acute ischemic nonembolic stroke in elderly subjects.
J Stroke Cerebrovasc Dis. 2010 Nov-Dec; 19(6):497-502.JS

Abstract

Among traditional cardiovascular risk factors, apolipoprotein (apo)B/apoA1 ratio is considered to have the strongest predictive value for ischemic stroke. Nevertheless, there are imsufficient data to support this ratio as an independent risk predictor of ischemic stroke in elderly individuals. In this case-control study, we evaluated apoB/apoA1 ratio as a predictor of ischemic stroke in a cohort of elderly subjects. A total of 163 patients aged>70 years (88 men) admitted due to a first-ever acute ischemic/nonembolic stroke and 166 volunteers (87 men) with no history of cardiovascular disease were included. The association between apoB/apoA1 ratio and stroke was determined by multivariate logistic regression modeling after adjusting for potential confounding factors, including lipid parameters. Stroke patients exhibited a higher apoB/apoA1 ratio than controls (1.04±0.33 vs 0.86±0.22; P<.001). In univariate analysis, crude odds ratio (OR) for apoB/apoA1 ratio was 1.27 per 0.1 increase (95% confidence interval [CI]=1.15-1.39; P<.001). Compared with subjects with an apoB/apoA1 ratio in the lowest quartile, those within the highest quartile had a 6.3-fold increase in the odds of suffering an ischemic stroke (95% CI=3.17-12.48; P<.001). This association remained significant after controlling for potential confounders, including sex, age, smoking status, body mass index, waist circumference, glucose and insulin levels, the presence of hypertension and diabetes mellitus, and lipid profile parameters (adjusted OR=3.02; 95% CI=1.16-7.83; P=.02). Our findings support elevated apoB/apoA1 ratio as an independent predictor of ischemic stroke in individuals over age 70.

Authors+Show Affiliations

Department of Internal Medicine, School of Medicine, University of Ioannina, Ioannina, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20538481

Citation

Kostapanos, Michael S., et al. "Apolipoprotein B-to-A1 Ratio as a Predictor of Acute Ischemic Nonembolic Stroke in Elderly Subjects." Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association, vol. 19, no. 6, 2010, pp. 497-502.
Kostapanos MS, Christogiannis LG, Bika E, et al. Apolipoprotein B-to-A1 ratio as a predictor of acute ischemic nonembolic stroke in elderly subjects. J Stroke Cerebrovasc Dis. 2010;19(6):497-502.
Kostapanos, M. S., Christogiannis, L. G., Bika, E., Bairaktari, E. T., Goudevenos, J. A., Elisaf, M. S., & Milionis, H. J. (2010). Apolipoprotein B-to-A1 ratio as a predictor of acute ischemic nonembolic stroke in elderly subjects. Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association, 19(6), 497-502. https://doi.org/10.1016/j.jstrokecerebrovasdis.2009.09.010
Kostapanos MS, et al. Apolipoprotein B-to-A1 Ratio as a Predictor of Acute Ischemic Nonembolic Stroke in Elderly Subjects. J Stroke Cerebrovasc Dis. 2010 Nov-Dec;19(6):497-502. PubMed PMID: 20538481.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein B-to-A1 ratio as a predictor of acute ischemic nonembolic stroke in elderly subjects. AU - Kostapanos,Michael S, AU - Christogiannis,Leonidas G, AU - Bika,Eftychia, AU - Bairaktari,Eleni T, AU - Goudevenos,John A, AU - Elisaf,Moses S, AU - Milionis,Haralampos J, Y1 - 2010/06/09/ PY - 2009/06/16/received PY - 2009/08/24/revised PY - 2009/09/10/accepted PY - 2010/6/12/entrez PY - 2010/6/12/pubmed PY - 2011/2/26/medline SP - 497 EP - 502 JF - Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association JO - J Stroke Cerebrovasc Dis VL - 19 IS - 6 N2 - Among traditional cardiovascular risk factors, apolipoprotein (apo)B/apoA1 ratio is considered to have the strongest predictive value for ischemic stroke. Nevertheless, there are imsufficient data to support this ratio as an independent risk predictor of ischemic stroke in elderly individuals. In this case-control study, we evaluated apoB/apoA1 ratio as a predictor of ischemic stroke in a cohort of elderly subjects. A total of 163 patients aged>70 years (88 men) admitted due to a first-ever acute ischemic/nonembolic stroke and 166 volunteers (87 men) with no history of cardiovascular disease were included. The association between apoB/apoA1 ratio and stroke was determined by multivariate logistic regression modeling after adjusting for potential confounding factors, including lipid parameters. Stroke patients exhibited a higher apoB/apoA1 ratio than controls (1.04±0.33 vs 0.86±0.22; P<.001). In univariate analysis, crude odds ratio (OR) for apoB/apoA1 ratio was 1.27 per 0.1 increase (95% confidence interval [CI]=1.15-1.39; P<.001). Compared with subjects with an apoB/apoA1 ratio in the lowest quartile, those within the highest quartile had a 6.3-fold increase in the odds of suffering an ischemic stroke (95% CI=3.17-12.48; P<.001). This association remained significant after controlling for potential confounders, including sex, age, smoking status, body mass index, waist circumference, glucose and insulin levels, the presence of hypertension and diabetes mellitus, and lipid profile parameters (adjusted OR=3.02; 95% CI=1.16-7.83; P=.02). Our findings support elevated apoB/apoA1 ratio as an independent predictor of ischemic stroke in individuals over age 70. SN - 1532-8511 UR - https://www.unboundmedicine.com/medline/citation/20538481/Apolipoprotein_B_to_A1_ratio_as_a_predictor_of_acute_ischemic_nonembolic_stroke_in_elderly_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1052-3057(09)00199-2 DB - PRIME DP - Unbound Medicine ER -