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Relationship between severity of coronary artery disease and apolipoprotein E gene polymorphism.
Anadolu Kardiyol Derg. 2010 Jun; 10(3):202-8.AK

Abstract

OBJECTIVE

To explore the possible contribution of the apolipoprotein (apo) E polymorphisms to the extent and severity of coronary artery disease (CAD) related to lipid metabolism.

METHODS

Overall, 53 Turkish patients, aged 54+/-11 years defined by coronary angiography were included in this cross-sectional study. Reardon's coronary artery scoring was used. Serum lipids were measured with enzymatic colorimetric methods. Apolipoproteins were measured with nephelometry. Apolipoprotein E gene polymorphisms were determined by the reverse hybridization method. Statistical analyses were performed using one-way ANOVA, Kruskal-Wallis and Chi- square tests.

RESULTS

The genotype frequencies were 7.5% for E2/E3, 77.4% for E3/E3 and 15.1% for E3/E4. The E2 allele frequency was slightly lower than E4 allele. There were no significant differences between apo E2/E3, E3/E3 and E3/E4 genotypes for severity scorings (26, 41 and 32 respectively, p=0.30) and extent scorings (3.2, 5.5, 4.5, p=0.17). It was found that the most of patients who had E2/3 and E3/4 alleles had low severity scores. On the other hand, there were no significant score difference for patients who had E3/3 alleles. Lipids were not significantly different among the different genotypes. The E3 allele was associated with high apo B levels compared with E2 and E4 genotypes. It was found that severity and extent of disease were not related with lipid metabolism.

CONCLUSION

We concluded that there were no statistically significant differences between genotypes for extent and severity scorings, but the apo E3 allele is associated with more severe disease than E2 allele. These associations with severity were mediated not only by changes in lipid metabolism but may be also by other mechanisms in CAD patients.

Authors+Show Affiliations

Department of Biochemistry and Clinical Biochemistry, Aksaray State Hospital, Aksaray, Turkey. fatmademet.arslan@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20538553

Citation

Arslan Ince, F Demet, et al. "Relationship Between Severity of Coronary Artery Disease and Apolipoprotein E Gene Polymorphism." Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology, vol. 10, no. 3, 2010, pp. 202-8.
Arslan Ince FD, Atay A, Köseoğlu M, et al. Relationship between severity of coronary artery disease and apolipoprotein E gene polymorphism. Anadolu Kardiyol Derg. 2010;10(3):202-8.
Arslan Ince, F. D., Atay, A., Köseoğlu, M., Yeşil, M., & Deveci, E. (2010). Relationship between severity of coronary artery disease and apolipoprotein E gene polymorphism. Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology, 10(3), 202-8. https://doi.org/10.5152/akd.2010.058
Arslan Ince FD, et al. Relationship Between Severity of Coronary Artery Disease and Apolipoprotein E Gene Polymorphism. Anadolu Kardiyol Derg. 2010;10(3):202-8. PubMed PMID: 20538553.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between severity of coronary artery disease and apolipoprotein E gene polymorphism. AU - Arslan Ince,F Demet, AU - Atay,Ayşenur, AU - Köseoğlu,Mehmet, AU - Yeşil,Murat, AU - Deveci,Erdal, PY - 2010/6/12/entrez PY - 2010/6/12/pubmed PY - 2010/10/30/medline SP - 202 EP - 8 JF - Anadolu kardiyoloji dergisi : AKD = the Anatolian journal of cardiology JO - Anadolu Kardiyol Derg VL - 10 IS - 3 N2 - OBJECTIVE: To explore the possible contribution of the apolipoprotein (apo) E polymorphisms to the extent and severity of coronary artery disease (CAD) related to lipid metabolism. METHODS: Overall, 53 Turkish patients, aged 54+/-11 years defined by coronary angiography were included in this cross-sectional study. Reardon's coronary artery scoring was used. Serum lipids were measured with enzymatic colorimetric methods. Apolipoproteins were measured with nephelometry. Apolipoprotein E gene polymorphisms were determined by the reverse hybridization method. Statistical analyses were performed using one-way ANOVA, Kruskal-Wallis and Chi- square tests. RESULTS: The genotype frequencies were 7.5% for E2/E3, 77.4% for E3/E3 and 15.1% for E3/E4. The E2 allele frequency was slightly lower than E4 allele. There were no significant differences between apo E2/E3, E3/E3 and E3/E4 genotypes for severity scorings (26, 41 and 32 respectively, p=0.30) and extent scorings (3.2, 5.5, 4.5, p=0.17). It was found that the most of patients who had E2/3 and E3/4 alleles had low severity scores. On the other hand, there were no significant score difference for patients who had E3/3 alleles. Lipids were not significantly different among the different genotypes. The E3 allele was associated with high apo B levels compared with E2 and E4 genotypes. It was found that severity and extent of disease were not related with lipid metabolism. CONCLUSION: We concluded that there were no statistically significant differences between genotypes for extent and severity scorings, but the apo E3 allele is associated with more severe disease than E2 allele. These associations with severity were mediated not only by changes in lipid metabolism but may be also by other mechanisms in CAD patients. SN - 1308-0032 UR - https://www.unboundmedicine.com/medline/citation/20538553/Relationship_between_severity_of_coronary_artery_disease_and_apolipoprotein_E_gene_polymorphism_ L2 - http://www.anatoljcardiol.com/linkout/?PMID=20538553 DB - PRIME DP - Unbound Medicine ER -