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Continued evolution of H5N1 influenza viruses in wild birds, domestic poultry, and humans in China from 2004 to 2009.
J Virol 2010; 84(17):8389-97JV

Abstract

Despite substantial efforts to control H5N1 avian influenza viruses (AIVs), the viruses have continued to evolve and cause disease outbreaks in poultry and infections in humans. In this report, we analyzed 51 representative H5N1 AIVs isolated from domestic poultry, wild birds, and humans in China during 2004 to 2009, and 21 genotypes were detected based on whole-genome sequences. Twelve genotypes of AIVs in southern China bear similar H5 hemagglutinin (HA) genes (clade 2.3). These AIVs did not display antigenic drift and could be completely protected against by the A/goose/Guangdong/1/96 (GS/GD/1/96)-based oil-adjuvanted killed vaccine and recombinant Newcastle disease virus vaccine, which have been used in China. In addition, antigenically drifted H5N1 viruses, represented by A/chicken/Shanxi/2/06 (CK/SX/2/06), were detected in chickens from several provinces in northern China. The CK/SX/2/06-like viruses are reassortants with newly emerged HA, NA, and PB1 genes that could not be protected against by the GS/GD/1/96-based vaccines. These viruses also reacted poorly with antisera generated from clade 2.2 and 2.3 viruses. The majority of the viruses isolated from southern China were lethal in mice and ducks, while the CK/SX/2/06-like viruses caused mild disease in mice and could not replicate in ducks. Our results demonstrate that the H5N1 AIVs circulating in nature have complex biological characteristics and pose a continued challenge for disease control and pandemic preparedness.

Authors+Show Affiliations

Animal Influenza Laboratory of the Ministry of Agriculture and National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, CAAS, 427 Maduan Street, Harbin 150001, People's Republic of China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20538856

Citation

Li, Yanbing, et al. "Continued Evolution of H5N1 Influenza Viruses in Wild Birds, Domestic Poultry, and Humans in China From 2004 to 2009." Journal of Virology, vol. 84, no. 17, 2010, pp. 8389-97.
Li Y, Shi J, Zhong G, et al. Continued evolution of H5N1 influenza viruses in wild birds, domestic poultry, and humans in China from 2004 to 2009. J Virol. 2010;84(17):8389-97.
Li, Y., Shi, J., Zhong, G., Deng, G., Tian, G., Ge, J., ... Chen, H. (2010). Continued evolution of H5N1 influenza viruses in wild birds, domestic poultry, and humans in China from 2004 to 2009. Journal of Virology, 84(17), pp. 8389-97. doi:10.1128/JVI.00413-10.
Li Y, et al. Continued Evolution of H5N1 Influenza Viruses in Wild Birds, Domestic Poultry, and Humans in China From 2004 to 2009. J Virol. 2010;84(17):8389-97. PubMed PMID: 20538856.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Continued evolution of H5N1 influenza viruses in wild birds, domestic poultry, and humans in China from 2004 to 2009. AU - Li,Yanbing, AU - Shi,Jianzhong, AU - Zhong,Gongxun, AU - Deng,Guohua, AU - Tian,Guobin, AU - Ge,Jinying, AU - Zeng,Xianying, AU - Song,Jiasheng, AU - Zhao,Dongming, AU - Liu,Liling, AU - Jiang,Yongping, AU - Guan,Yuntao, AU - Bu,Zhigao, AU - Chen,Hualan, Y1 - 2010/06/10/ PY - 2010/6/12/entrez PY - 2010/6/12/pubmed PY - 2010/9/18/medline SP - 8389 EP - 97 JF - Journal of virology JO - J. Virol. VL - 84 IS - 17 N2 - Despite substantial efforts to control H5N1 avian influenza viruses (AIVs), the viruses have continued to evolve and cause disease outbreaks in poultry and infections in humans. In this report, we analyzed 51 representative H5N1 AIVs isolated from domestic poultry, wild birds, and humans in China during 2004 to 2009, and 21 genotypes were detected based on whole-genome sequences. Twelve genotypes of AIVs in southern China bear similar H5 hemagglutinin (HA) genes (clade 2.3). These AIVs did not display antigenic drift and could be completely protected against by the A/goose/Guangdong/1/96 (GS/GD/1/96)-based oil-adjuvanted killed vaccine and recombinant Newcastle disease virus vaccine, which have been used in China. In addition, antigenically drifted H5N1 viruses, represented by A/chicken/Shanxi/2/06 (CK/SX/2/06), were detected in chickens from several provinces in northern China. The CK/SX/2/06-like viruses are reassortants with newly emerged HA, NA, and PB1 genes that could not be protected against by the GS/GD/1/96-based vaccines. These viruses also reacted poorly with antisera generated from clade 2.2 and 2.3 viruses. The majority of the viruses isolated from southern China were lethal in mice and ducks, while the CK/SX/2/06-like viruses caused mild disease in mice and could not replicate in ducks. Our results demonstrate that the H5N1 AIVs circulating in nature have complex biological characteristics and pose a continued challenge for disease control and pandemic preparedness. SN - 1098-5514 UR - https://www.unboundmedicine.com/medline/citation/20538856/Continued_evolution_of_H5N1_influenza_viruses_in_wild_birds_domestic_poultry_and_humans_in_China_from_2004_to_2009_ L2 - http://jvi.asm.org/cgi/pmidlookup?view=long&pmid=20538856 DB - PRIME DP - Unbound Medicine ER -