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Metabolic syndrome and carotid intima-media thickness in young adults: roles of apolipoprotein B, apolipoprotein A-I, C-reactive protein, and secretory phospholipase A2: the cardiovascular risk in young Finns study.
Arterioscler Thromb Vasc Biol 2010; 30(9):1861-6AT

Abstract

OBJECTIVE

Aberrations in apolipoprotein (apo) metabolism and increased systemic inflammation associate with the metabolic syndrome (MetS) and may contribute to its atherogenicity. We examined whether the association between carotid atherosclerosis and MetS in a population of young adults is mediated by apoB and apoA-I and/or by inflammatory markers C-reactive protein and type II secretory phospholipase A2.

METHODS AND RESULTS

We used cross-sectional and 6-year prospective data from the cardiovascular risk in young Finns study. In young adults (aged 24 to 39 years), apoB, C-reactive protein, and type II secretory phospholipase A2 enzyme activity were significantly higher and apoA-I lower in subjects with MetS (N=325) than in subjects without MetS (N=1858). In prospective analysis (N=1587), both MetS and high apoB predicted (P<0.0001) incident high carotid intima-media thickness, defined as carotid intima-media thickness >90th percentile and/or plaque. The association between MetS and incident high carotid intima-media thickness was attenuated by approximately 40% after adjustment with apoB. Adjustments with apoA-I, C-reactive protein, or type II secretory phospholipase A2 did not diminish the association.

CONCLUSIONS

High levels of apoB, C-reactive protein, and type II secretory phospholipase A2 and low levels of apoA-I associate with MetS in young adults. The atherogenicity of MetS in this population assessed by incident high carotid intima-media thickness appears to be substantially mediated by elevated apoB but not inflammatory markers.

Authors+Show Affiliations

The Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku and Turku University Hospital, Finland. noora.mattsson@utu.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20539018

Citation

Mattsson, Noora, et al. "Metabolic Syndrome and Carotid Intima-media Thickness in Young Adults: Roles of Apolipoprotein B, Apolipoprotein A-I, C-reactive Protein, and Secretory Phospholipase A2: the Cardiovascular Risk in Young Finns Study." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 30, no. 9, 2010, pp. 1861-6.
Mattsson N, Magnussen CG, Rönnemaa T, et al. Metabolic syndrome and carotid intima-media thickness in young adults: roles of apolipoprotein B, apolipoprotein A-I, C-reactive protein, and secretory phospholipase A2: the cardiovascular risk in young Finns study. Arterioscler Thromb Vasc Biol. 2010;30(9):1861-6.
Mattsson, N., Magnussen, C. G., Rönnemaa, T., Mallat, Z., Benessiano, J., Jula, A., ... Raitakari, O. T. (2010). Metabolic syndrome and carotid intima-media thickness in young adults: roles of apolipoprotein B, apolipoprotein A-I, C-reactive protein, and secretory phospholipase A2: the cardiovascular risk in young Finns study. Arteriosclerosis, Thrombosis, and Vascular Biology, 30(9), pp. 1861-6. doi:10.1161/ATVBAHA.110.204669.
Mattsson N, et al. Metabolic Syndrome and Carotid Intima-media Thickness in Young Adults: Roles of Apolipoprotein B, Apolipoprotein A-I, C-reactive Protein, and Secretory Phospholipase A2: the Cardiovascular Risk in Young Finns Study. Arterioscler Thromb Vasc Biol. 2010;30(9):1861-6. PubMed PMID: 20539018.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Metabolic syndrome and carotid intima-media thickness in young adults: roles of apolipoprotein B, apolipoprotein A-I, C-reactive protein, and secretory phospholipase A2: the cardiovascular risk in young Finns study. AU - Mattsson,Noora, AU - Magnussen,Costan G, AU - Rönnemaa,Tapani, AU - Mallat,Ziad, AU - Benessiano,Joelle, AU - Jula,Antti, AU - Taittonen,Leena, AU - Kähönen,Mika, AU - Juonala,Markus, AU - Viikari,Jorma S A, AU - Raitakari,Olli T, Y1 - 2010/06/10/ PY - 2010/6/12/entrez PY - 2010/6/12/pubmed PY - 2010/9/21/medline SP - 1861 EP - 6 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler. Thromb. Vasc. Biol. VL - 30 IS - 9 N2 - OBJECTIVE: Aberrations in apolipoprotein (apo) metabolism and increased systemic inflammation associate with the metabolic syndrome (MetS) and may contribute to its atherogenicity. We examined whether the association between carotid atherosclerosis and MetS in a population of young adults is mediated by apoB and apoA-I and/or by inflammatory markers C-reactive protein and type II secretory phospholipase A2. METHODS AND RESULTS: We used cross-sectional and 6-year prospective data from the cardiovascular risk in young Finns study. In young adults (aged 24 to 39 years), apoB, C-reactive protein, and type II secretory phospholipase A2 enzyme activity were significantly higher and apoA-I lower in subjects with MetS (N=325) than in subjects without MetS (N=1858). In prospective analysis (N=1587), both MetS and high apoB predicted (P<0.0001) incident high carotid intima-media thickness, defined as carotid intima-media thickness >90th percentile and/or plaque. The association between MetS and incident high carotid intima-media thickness was attenuated by approximately 40% after adjustment with apoB. Adjustments with apoA-I, C-reactive protein, or type II secretory phospholipase A2 did not diminish the association. CONCLUSIONS: High levels of apoB, C-reactive protein, and type II secretory phospholipase A2 and low levels of apoA-I associate with MetS in young adults. The atherogenicity of MetS in this population assessed by incident high carotid intima-media thickness appears to be substantially mediated by elevated apoB but not inflammatory markers. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/20539018/Metabolic_syndrome_and_carotid_intima_media_thickness_in_young_adults:_roles_of_apolipoprotein_B_apolipoprotein_A_I_C_reactive_protein_and_secretory_phospholipase_A2:_the_cardiovascular_risk_in_young_Finns_study_ L2 - http://www.ahajournals.org/doi/full/10.1161/ATVBAHA.110.204669?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -