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The omega-3 fatty acids EPA and DHA decrease plasma F(2)-isoprostanes: Results from two placebo-controlled interventions.
Free Radic Res. 2010 Sep; 44(9):983-90.FR

Abstract

Omega-3 (omega3) fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), protect against cardiovascular disease. Despite these benefits, concern remains that omega3 fatty acids may increase lipid peroxidation. It has previously been shown that urinary F(2)-isoprostanes (F(2)-IsoPs) were reduced following omega3 fatty acid supplementation in humans. It is now determined whether EPA or DHA supplementation affects plasma F(2)-IsoPs. In two 6-week placebo-controlled interventions, Study A: overweight, dyslipidaemic men; and Study B: treated-hypertensive Type 2 diabetic, patients were randomized to 4 g daily EPA, DHA. Post-intervention plasma F(2)-IsoPs were significantly reduced by EPA (24% in Study A, 19% in Study B) and by DHA (14% in Study A, 23% in Study B) relative to the olive oil group. The fall in plasma F(2)-IsoPs was not altered in analyses that corrected for changes in plasma arachidonic acid, which was reduced with EPA and DHA supplementation. Neither F(3)- nor F(4)-IsoPs were observed in plasma in both studies. These results show that in humans, EPA and DHA reduce in vivo oxidant stress as measured in human plasma and urine.

Authors+Show Affiliations

University of Western Australia, Perth, WA, Australia. emilie.mas@uwa.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20540666

Citation

Mas, Emilie, et al. "The Omega-3 Fatty Acids EPA and DHA Decrease Plasma F(2)-isoprostanes: Results From Two Placebo-controlled Interventions." Free Radical Research, vol. 44, no. 9, 2010, pp. 983-90.
Mas E, Woodman RJ, Burke V, et al. The omega-3 fatty acids EPA and DHA decrease plasma F(2)-isoprostanes: Results from two placebo-controlled interventions. Free Radic Res. 2010;44(9):983-90.
Mas, E., Woodman, R. J., Burke, V., Puddey, I. B., Beilin, L. J., Durand, T., & Mori, T. A. (2010). The omega-3 fatty acids EPA and DHA decrease plasma F(2)-isoprostanes: Results from two placebo-controlled interventions. Free Radical Research, 44(9), 983-90. https://doi.org/10.3109/10715762.2010.492830
Mas E, et al. The Omega-3 Fatty Acids EPA and DHA Decrease Plasma F(2)-isoprostanes: Results From Two Placebo-controlled Interventions. Free Radic Res. 2010;44(9):983-90. PubMed PMID: 20540666.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The omega-3 fatty acids EPA and DHA decrease plasma F(2)-isoprostanes: Results from two placebo-controlled interventions. AU - Mas,Emilie, AU - Woodman,Richard J, AU - Burke,Valerie, AU - Puddey,Ian B, AU - Beilin,Lawrence J, AU - Durand,Thierry, AU - Mori,Trevor A, PY - 2010/6/15/entrez PY - 2010/6/15/pubmed PY - 2011/1/19/medline SP - 983 EP - 90 JF - Free radical research JO - Free Radic Res VL - 44 IS - 9 N2 - Omega-3 (omega3) fatty acids, particularly eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), protect against cardiovascular disease. Despite these benefits, concern remains that omega3 fatty acids may increase lipid peroxidation. It has previously been shown that urinary F(2)-isoprostanes (F(2)-IsoPs) were reduced following omega3 fatty acid supplementation in humans. It is now determined whether EPA or DHA supplementation affects plasma F(2)-IsoPs. In two 6-week placebo-controlled interventions, Study A: overweight, dyslipidaemic men; and Study B: treated-hypertensive Type 2 diabetic, patients were randomized to 4 g daily EPA, DHA. Post-intervention plasma F(2)-IsoPs were significantly reduced by EPA (24% in Study A, 19% in Study B) and by DHA (14% in Study A, 23% in Study B) relative to the olive oil group. The fall in plasma F(2)-IsoPs was not altered in analyses that corrected for changes in plasma arachidonic acid, which was reduced with EPA and DHA supplementation. Neither F(3)- nor F(4)-IsoPs were observed in plasma in both studies. These results show that in humans, EPA and DHA reduce in vivo oxidant stress as measured in human plasma and urine. SN - 1029-2470 UR - https://www.unboundmedicine.com/medline/citation/20540666/The_omega_3_fatty_acids_EPA_and_DHA_decrease_plasma_F_2__isoprostanes:_Results_from_two_placebo_controlled_interventions_ L2 - https://www.tandfonline.com/doi/full/10.3109/10715762.2010.492830 DB - PRIME DP - Unbound Medicine ER -