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Caffeine consumption during pregnancy and spontaneous abortion.
Epidemiology 1991; 2(3):168-74E

Abstract

We conducted a case-control study of spontaneous abortion in Santa Clara County, California between 1986 and 1987. We analyzed data on 607 cases and 1,284 controls to evaluate the potential association between caffeine consumption during the first trimester of pregnancy and spontaneous abortion. About 70% of the women consumed caffeinated coffee, tea, and/or soda; 7% of the women consumed more than an average of 300 mg of caffeine daily. The crude odds ratio (OR) for heavy caffeine consumption (greater than 300 mg/day) was 1.55 (95% CI: 1.04-2.31), which decreased to 1.22 (95% CI: 0.80-1.87) after controlling for confounding factors. For these heavy users, nausea modified the association of spontaneous abortion and caffeine; heavy caffeine consumers reporting nausea had a doubled risk for spontaneous abortion (adjusted OR = 2.10, 95% CI: 1.20-3.70), in contrast to those who did not report nausea (adjusted OR = 0.53, 95% CI: 0.27-1.04). Heavy caffeine consumers who decreased their caffeine intake early in pregnancy had a risk of spontaneous abortion similar to that of nonconsumers.

Authors+Show Affiliations

California Department of Health Services, Reproductive Epidemiology Program, Berkeley 94704.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2054397

Citation

Fenster, L, et al. "Caffeine Consumption During Pregnancy and Spontaneous Abortion." Epidemiology (Cambridge, Mass.), vol. 2, no. 3, 1991, pp. 168-74.
Fenster L, Eskenazi B, Windham GC, et al. Caffeine consumption during pregnancy and spontaneous abortion. Epidemiology. 1991;2(3):168-74.
Fenster, L., Eskenazi, B., Windham, G. C., & Swan, S. H. (1991). Caffeine consumption during pregnancy and spontaneous abortion. Epidemiology (Cambridge, Mass.), 2(3), pp. 168-74.
Fenster L, et al. Caffeine Consumption During Pregnancy and Spontaneous Abortion. Epidemiology. 1991;2(3):168-74. PubMed PMID: 2054397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Caffeine consumption during pregnancy and spontaneous abortion. AU - Fenster,L, AU - Eskenazi,B, AU - Windham,G C, AU - Swan,S H, PY - 1991/5/1/pubmed PY - 1991/5/1/medline PY - 1991/5/1/entrez SP - 168 EP - 74 JF - Epidemiology (Cambridge, Mass.) JO - Epidemiology VL - 2 IS - 3 N2 - We conducted a case-control study of spontaneous abortion in Santa Clara County, California between 1986 and 1987. We analyzed data on 607 cases and 1,284 controls to evaluate the potential association between caffeine consumption during the first trimester of pregnancy and spontaneous abortion. About 70% of the women consumed caffeinated coffee, tea, and/or soda; 7% of the women consumed more than an average of 300 mg of caffeine daily. The crude odds ratio (OR) for heavy caffeine consumption (greater than 300 mg/day) was 1.55 (95% CI: 1.04-2.31), which decreased to 1.22 (95% CI: 0.80-1.87) after controlling for confounding factors. For these heavy users, nausea modified the association of spontaneous abortion and caffeine; heavy caffeine consumers reporting nausea had a doubled risk for spontaneous abortion (adjusted OR = 2.10, 95% CI: 1.20-3.70), in contrast to those who did not report nausea (adjusted OR = 0.53, 95% CI: 0.27-1.04). Heavy caffeine consumers who decreased their caffeine intake early in pregnancy had a risk of spontaneous abortion similar to that of nonconsumers. SN - 1044-3983 UR - https://www.unboundmedicine.com/medline/citation/2054397/Caffeine_consumption_during_pregnancy_and_spontaneous_abortion_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=2054397.ui DB - PRIME DP - Unbound Medicine ER -